Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus

Mohammad, Abolfathi; Falahi, Ebrahim; Yusof, Barakatun Nisak Mohd; Hanipah, Zubaidah Nor; Redzwan, S. Mohd; Yusof, Loqman Mohamad; Gheitasvand, Mohsen; Rezaie, Farahnaz

doi:10.1016/j.dsx.2021.05.031

Cited by 14 publications

(11 citation statements)

References 43 publications

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Section: Discussionsupporting

confidence: 86%

“…The low number of participants answering correctly on the pre-test for knowledge in the current study supports claims from previous research and highlights the gap in knowledge about the link between T2DM and heart disease in the general public and those with T2DM (Mohammad et al, 2021;Mosca et al, 2000; Niknian et al, 1989). Mohammad et al (2021) suggested the need for initiatives that educate and support the prevention of CVD in patients with T2DM. It has been widely demonstrated through meta-analysis and research reviews that information transfer through sustained educational initiatives about diabetes can be effective at improving markers of diabetes and heart disease, including improvements in HbA1 C, lipid profiles, knowledge and self-care behaviours (Boegner et al, 2008; De Silva Chaves et al, 2021; Loveman et al, 2008; Mikhael et al, 2020; Rashed et al, 2016; Świątoniowska et al, 2019).…”

Section: Discussionsupporting

confidence: 86%

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Know diabetes by heart: Education about the linkage between cardiovascular disease and diabetes

Parisi

McFall

Ankomah

et al. 2022

Health Education Journal

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Objective: The objective of this study was to investigate how a 1-hour education session that highlights American Heart Association/American Diabetes Association’s Know Diabetes by Heart (KDBH) messaging changed the knowledge and behavioural intention of participants. Design: Single group, quasi-experimental study evaluating the impact of the KDBH education intervention on participants’ knowledge and intentions to engage in risk-lowering behaviours related to the link between diabetes and cardiovascular disease. Setting: A free, 1-hour, synchronously delivered education session was offered through an online platform and facilitated by Cooperative Extension agents. Methods: A pre- and post-Qualtrics survey was used to assess changes in knowledge and intended behaviours. Slides were provided by the American Diabetes Association and tailored for clarification and evaluation purposes. Results: The study included 259 adults with an average age of 54 years (standard deviation [ SD] = 16.67) and 72.97% being 46 years or older. When participants were asked if having type 2 diabetes put them at risk for development of hypertension, unhealthy cholesterol levels, heart attack, or stroke, 84.84% answered correctly at baseline. After session completion, the percentage correct increased to 92.2% ( p = .002). Individual’s knowledge of cardiovascular disease as the leading cause of death for people with type 2 diabetes was assessed; 66.80% answered correctly pre-intervention. After completing the KDBH programme, 95.37% answered correctly ( p = .001). In addition, more than half of those with type 2 diabetes reported intended to adopt several behaviours related to reducing the risk of cardiovascular disease at the completion of the programme. Conclusions: The pilot study indicates successful information transfer in a 1-hour education session focused on chronic disease risks associated with T2DM. Results support the use of synchronous online platforms for diabetes and heart disease information transfer. Future prospective studies measuring sustained knowledge, behaviour adoption and incidence of heart-disease before and after education are needed.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Know diabetes by heart: Education about the linkage between cardiovascular disease and diabetes

Parisi

McFall

Ankomah

et al. 2022

Health Education Journal

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“…Metformin is known to suppress hepatic glucose production, increase peripheral glucose uptake, and enhance intestinal glucose usage [ 27 ]. Vitamin E supplementation has been shown to enhance insulin activity and decrease glucose levels due to its antioxidative effects [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective and Cardiometabolic Role of Vitamin E: Alleviating Neuroinflammation and Metabolic Disturbance Induced by AlCl3 in Rat Models

Jabeen,

Rehman,

Akash

et al. 2023

Biomedicines

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Cardiovascular diseases (CVDs) and neurodegenerative disorders, such as diabetes mellitus and Alzheimer’s disease, share a common pathophysiological link involving insulin resistance (IR), inflammation, and hypertension. Aluminium chloride (AlCl3), a known neurotoxicant, has been associated with neurodegeneration, cognitive impairment, and various organ dysfunctions due to the production of reactive oxygen species (ROS) and oxidative stress. In this study, we aimed to investigate the potential protective effects of metformin and vitamin E against AlCl3-induced neuroinflammation and cardiometabolic disturbances in rat models. Rats were divided into five groups: a normal control group, an AlCl3-treated diseased group without any treatment, and three groups exposed to AlCl3 and subsequently administered with metformin (100 mg/kg/day) alone, vitamin E (150 mg/kg/day) orally alone, or a combination of metformin (100 mg/kg/day) and vitamin E (150 mg/kg/day) for 45 days. We analyzed serum biomarkers and histopathological changes in brain, heart, and pancreatic tissues using H&E and Masson’s trichrome staining and immunohistochemistry (IHC). Electrocardiogram (ECG) patterns were observed for all groups. The AlCl3-treated group showed elevated levels of inflammatory biomarkers, MDA, and disturbances in glycemic and lipid profiles, along with reduced insulin levels. However, treatment with the combination of metformin and vitamin E resulted in significantly reduced glucose, cholesterol, LDL, and TG levels, accompanied by increased insulin and HDL levels compared to the individual treatment groups. Histopathological analyses revealed that combination therapy preserved neuronal structures, muscle cell nuclei, and normal morphology in the brain, heart, and pancreatic tissues. IHC demonstrated reduced amyloid plaques and neurofibrillary tangles in the combination-treated group compared to the AlCl3-treated group. Moreover, the combination group showed a normal ECG pattern, contrasting the altered pattern observed in the AlCl3-treated group. Overall, our findings suggest that metformin and vitamin E, in combination, possess neuroprotective and cardiometabolic effects, alleviating AlCl3-induced neuroinflammation and metabolic disturbances.

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“…50 Nonanoic acid stimulates GLP-1 and PYY via OR51E1 signaling in L cells, thus having a potential role in olfactory receptor-mediated events in GLP-1 and PYY secretion and thus potentially being used in therapeutic approaches to treat diabetes. 51 GLP-1 secretion has insulinotropic activity whose upregulation is considered a potential pharmacological target treating type 2 diabetes. 52 The ethanol extract of Allium saralicum with the main compounds linolenic acid-methyl ester, phytol, and neophytadiene can improve hyperglycemia due to diabetes and prevent anemia after diabetes by controlling hematological parameters.…”

Section: Figure 1 Gc-ms Analysis Ethanolic Extract Of Leaf T Flavesce...mentioning

confidence: 99%

Antidiabetic Potentials of Ethanol Extract of Timonius flavescens (Jacq.) Baker Leaf

2023

TJNPR

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Timonius flavescens (of the Rubiaceae genus) is a plant that has long been used by the Batak people in Sumatra to lower blood sugar level or diabetes. 9,10 Ethanol extract from T. flavescens has been shown to have antidiabetic properties and potentially as an immunostimulant agent. 8 T. flavescens contains various secondary metabolites such as terpenoids, saponins, phenolics and flavonoids. 20 This research was conducted to determine the content of compounds in the ethanol extract of T. flavescens leaves using mass spectrometry gas chromatography (GC-MS), which has antidiabetic properties. Materials and Methods Plant materialThe samples used in this study were Timonius flavescens leaves obtained in Sipahutar Village, North Sumatra, Indonesia which was collected in August 2021. The plant was identified by professor Tri Harsono from Universitas Negeri Medan with a reference number of No.0087/UN33.4.8.3/LB/2021. The leaves were cleaned with running water, then air-dried in a room protected from sunlight for approx. 5 days. The dried samples were then blended and filtered through a 60mesh sieve. Leaf extractA total of 250 grams T. flavescens leaf powder was macerated with 96% ethanol as a solvent of 1000 mL in a vessel for 5 days. Then the marinade was filtered with Whatman No 1 filter paper, then the pulp was macerated again with 96% ethanol and the same ratio (1:4) for up to 3 repetitions. 21 All the filtered macerate were mixed and evaporated with a vacuum rotary evaporator until it turned into viscous extract. It was then stored in a refrigerator at 4 0 C. 22 Phytochemical analysis Phytochemical analysis of the ethanol extract of the leaves of T. flavescens on secondary metabolites was carried out qualitatively, including testing for alkaloids, flavonoids, phenols, tannins, terpenoid saponins and steroids. The qualitative test for the content of secondary metabolites was carried out using the standard method. 23 Gas Chromatography-Mass Spectroscopy (GC-MS) Gas Chromatography-Mass Spectroscopy (Shimadzu QP 5000) was conducted using a non-polar DB-5 crosslinked column with a length of 30 m x ID 0.25 mm x 0.25 m film thickness, consisting of 5% phenyl

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Systematic review and meta-analyses of vitamin E (alpha-tocopherol) supplementation and blood lipid parameters in patients with diabetes mellitus

Cited by 14 publications

References 43 publications

Know diabetes by heart: Education about the linkage between cardiovascular disease and diabetes

Know diabetes by heart: Education about the linkage between cardiovascular disease and diabetes

Neuroprotective and Cardiometabolic Role of Vitamin E: Alleviating Neuroinflammation and Metabolic Disturbance Induced by AlCl3 in Rat Models

Antidiabetic Potentials of Ethanol Extract of Timonius flavescens (Jacq.) Baker Leaf

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