Systematic review and meta-analysis of epidemiological literature evaluating the association between exposure to man-made vitreous fibers and respiratory tract cancers

Egnot, Natalie Suder; Benson, Stacey; Vater, Mark; Hazan, Rebecca; Patel, Opal; Marsh, Gary M.

doi:10.1016/j.yrtph.2020.104585

Cited by 9 publications

(4 citation statements)

References 33 publications

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“…In contrast to animal studies, our findings do not support an association with lung cancer. An extensive review of cohort studies of other MMVF also did not identify an increased mortality risk from respiratory cancers (Suder Egnot et al, 2020). The present study also found the SMR for deaths from all causes, and all cancers were at or below expected for the full cohort and both exposure groups.…”

Section: Discussionmentioning

confidence: 99%

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

LeMasters

Lockey

Hilbert

et al. 2022

J of Applied Toxicology

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This study evaluates the possible association between refractory ceramic fiber (RCF) exposure and all causes of death. Current and former employees (n = 1,119) hired from 1952 to 1999 at manufacturing facilities in New York (NY) state and Indiana were included. Work histories and quarterly plant-wide sampling from 1987 to 2015 provided cumulative fiber exposure (CFE) estimates. The full cohort was evaluated as well as individuals with lower and higher exposure, <45 and ≥45 fiber-months/cc.The Life-Table-Analysis-System was used for all standardized mortality rates (SMRs).Person-years at risk were accumulated from start of employment until 12/31/2019 or date of death. There was no significant association with all causes, all cancers, or lung cancer in any group. In the higher exposed, there was a significant elevation in both malignancies of the "urinary organs" (SMR = 3.59, 95% confidence interval[CI] 1.44, 7.40) and "bladder or other urinary site" (SMR = 4.04, 95% CI 1.10, 10.36), which persisted in comparison to regional mortality rates from NY state and Niagara County. However, six of the nine workers with urinary cancers were known smokers.In the lower exposed, there was a significant elevation in malignancies of the lymphatic and hematopoietic system (SMR = 2.54, 95% CI 1.27, 4.55) and leukemia (SMR = 4.21, 95% CI 1.69, 8.67). There was one pathologically unconfirmed mesothelioma death. A second employee currently living with a pathologically confirmed mesothelioma was identified, but the SMR was non-significant when both were included in the analyses. The association of these two mesothelioma cases with RCF exposure alone is unclear because of potential past exposure to asbestos.

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Section: Discussionmentioning

confidence: 99%

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

LeMasters

Lockey

Hilbert

et al. 2022

J of Applied Toxicology

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“…† However, in an earlier in vivo study it is shown that stone wool bres produced with and without binder perform similarly (Wagner et al, 1982, 21 Experiment 1 for stone wool bres injected intrapleurally). Fibre safety is also largely explored by epidemiological studies [7][8][9][10][11][12][13] at manufacturing sites, where no adverse effects of stone wool bres as produced, meaning possibly with binder, 31 are found on workers. Epidemiology is the rst type of studies that IARC 22 is using to investigate carcinogenicity of substances, including stone wool bres, followed by in vivo investigations.…”

Section: Introductionmentioning

confidence: 99%

“…1272/2008 (CLP) (EC2008)) and epidemiological studies on workers, where the impact of fibres produced with binder is studied, both recognised at international and European level. 7–13 Despite this, the papers 1–3 attempted to find differences in the in vitro acellular behaviour of fibres with and without binder, using binder removal techniques that modify fibre chemistry, 14,15 wettability and thus likely solubility. 16,17 The paper 1 explored the distribution of binder (presumably phenol-urea-formaldehyde, PUF) on stone wool fibres and tried to find a correlation between dissolution rate of stone wool measured in a simulated lung fluid (phagolysosomal simulant fluid, PSF) and the amount and thickness of organic material on the fibre surface.…”

Section: Introductionmentioning

confidence: 99%

Comment on “Which fraction of stone wool fibre surface remains uncoated by binder? A detailed analysis by time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy” by Hirth et al., 2021, RSC Adv., 11, 39545, DOI: 10.1039/d1ra06251d

et al. 2023

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“…Development of laryngeal carcinoma is related to multiple factors. Among the main causes of laryngeal carcinoma smoking accounts for 90% of the causes 9 . Other factors involved are alcohol, pan chewing, plummer winson syndrome etc.…”

Section: Introductionmentioning

confidence: 99%

Impact of Different Suturing Techniques used to from Neopharynx on Postop Pharyngocutaneous Fistula Development after total Laryngectomy

Aleem¹,

Aziz²,

Rehman³

et al. 2022

PJMHS

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Background: Laryngeal cancers are the second most common cancers in aero digestive tract. In advanced laryngeal cancers total laryngectomy is performed and it gives excellent results post operatively as the 5 year survival rate is 95%. One of the most common complication of total laryngectomy is formation of pharyngocutaneous fistula post operatively. Aim: To compare interrupted vs continuous suturing technique in formation of neopharynx after total laryngectomy in order to find out which technique is better in terms of pharyngocutaneous fistula formation postoperatively. Method: A total of 20 patients requiring total laryngectomy were selected. Patients were segregated into two groups. patients in group A underwent continuous suturing technique and those in group B underwent interrupted suturing technique in formation of neopharynx. Patients were then post operatively monitored for pharyngocutaneous fistula formation for 10 post operative days Result: Mean age in group-a patients was 56.90±12.94 year and 54.60±9.31 year in group-b patients. Pharyngocutaneous fistula developed in 2(20%) patients with interrupted suturing technique and in 7(70%) patients with continuous suturing technique used for formation of neopharynx. Conclusion: Hence it was concluded from our research that formation of neophaynx per operatively using interrupted suturing technique has less incidence of pharyngocutaneous fistula formation postoperatively then continuous suturing technique as it provides more strength to the wall of neopharynx and has less chances of dehiscence. Keywords: Neopharynx , Laryngectomy , Pharyngocutaneous fistula

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Systematic review and meta-analysis of epidemiological literature evaluating the association between exposure to man-made vitreous fibers and respiratory tract cancers

Cited by 9 publications

References 33 publications

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

Comment on “Which fraction of stone wool fibre surface remains uncoated by binder? A detailed analysis by time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy” by Hirth et al., 2021, RSC Adv., 11, 39545, DOI: 10.1039/d1ra06251d

Impact of Different Suturing Techniques used to from Neopharynx on Postop Pharyngocutaneous Fistula Development after total Laryngectomy

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