Systematic review and meta-analysis of probiotic use on inflammatory biomarkers and disease prevention in cattle

“…Subcutaneous vaccinations containing inactivated bacterial components and/or protein subunits were found to significantly reduce the incidence of puerperal metritis in heifers, leading to improved reproductive performance [ 89 ]. Other areas of investigation include but are not limited to probiotics, bacteriophages, acetylsalicylic acid, botanical essential oils, chitosan microparticles and even acupuncture therapy, with varying success—further research is needed in this field [ 38 , 90 , 91 , 92 ].…”

Section: Treatment Alternatives With Regard To Probioticsmentioning

confidence: 99%

Uterine Disease in Dairy Cows: A Comprehensive Review Highlighting New Research Areas

Várhidi,

Csikó,

Bajcsy

et al. 2024

Veterinary Sciences

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Uterine disease is an intensely studied part of dairy cattle health management as it heavily affects many commercial dairy farms and has serious economic consequences. Forms of the disease, pathophysiology, pathogens involved and the effects of uterine disease on the health and performance of cows have already been well described by various authors. Lately, researchers’ attention has shifted towards the healthy microbiome of the uterus and the vagina to put emphasis on prevention rather than treatment. This aligns with the growing demand to reduce the use of antibiotics or—whenever possible—replace them with alternative treatment options in farm animal medicine. This review provides a comprehensive summary of the last 20 years of uterine disease research and highlights promising new areas for future studies.

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“…Recent studies indicate that a shift from aerobic to anaerobic microbes occurs around six weeks of age [ 14 , 24 ]. Within this context, the concept of utilising direct-fed microbials (DFMs) gains significance [ 25 ]. An effective DFM should ideally be tailored to support the proliferation of the indigenous microbiota that naturally inhabits the calf’s GIT [ 1 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Lactobacilli-Based Direct-Fed Microbial Product on Gut Microbiota and Gastrointestinal Morphological Changes

Alawneh,

Ramay,

Olchowy

et al. 2024

Animals

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The calf’s gastrointestinal tract (GIT) microbiome undergoes rapid shifts during early post-natal life, which can directly affect calf performance. The objectives of this study were to characterise and compare differences in the establishment and succession of GIT microbiota, GIT morphological changes, and the growth of dairy calves from birth until weaned. Forty-four newborn Holstein-Friesian calves were randomly selected and assigned to Treatment (TRT) and Control (CON) groups. The TRT group calves received a once-daily dose of a direct-fed microbial (DFM) liquid product containing Lacticaseibacillus paracasei, Lentilactobacillus buchneri, and Lacticaseibacillus casei, all formerly known as Lactobacillus. Fresh faecal samples were manually taken from the rectum of all calves, and gross necropsy was performed on the forestomachs and gastrointestinal tracts. Bacterial DNA was extracted from frozen faecal samples for 16S rRNA gene amplicon sequencing. Calves in the TRT group had greater live weights (p = 0.02) at weaning compared with calves in the CON group (mean = 69.18 kg, SD = 13.37 kg). The average daily live weight gain (ADG) and total feed intake were similar between the two groups. Calves in the TRT group had greater duodenum, abomasum, and reticulum weights (p = 0.05). Rumen and intestinal development (p < 0.05) and faecal microbial diversity (p < 0.05) were more pronounced in the TRT group. The relative abundances of eight genera differed (p < 0.001) between the groups. Supplementing calves with the LAB-based DFM increased live weight at weaning and had a more pronounced effect on the development of rumen and the gastrointestinal tract and on microbiota diversity and evenness. Future work is needed to better understand the potential association of LAB-DFM products on gut mucosa-associated microbiota.

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Systematic review and meta-analysis of probiotic use on inflammatory biomarkers and disease prevention in cattle

Cited by 10 publications

References 92 publications

An overview on mastitis-associated Escherichia coli: Pathogenicity, host immunity and the use of alternative therapies

An overview on mastitis-associated Escherichia coli: Pathogenicity, host immunity and the use of alternative therapies

Uterine Disease in Dairy Cows: A Comprehensive Review Highlighting New Research Areas

Effect of a Lactobacilli-Based Direct-Fed Microbial Product on Gut Microbiota and Gastrointestinal Morphological Changes

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