Systematic review and meta-analysis of reports of patients with gastric cancer aged 80 years and older

Onagi, Chihiro; Oba, Mari S.; Oshima, Yoshiteru; Shimada, Hideaki

doi:10.1007/s13691-022-00563-w

Int Canc Conf J

2022

DOI: 10.1007/s13691-022-00563-w

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Systematic review and meta-analysis of reports of patients with gastric cancer aged 80 years and older

Chihiro Onagi

Mari S. Oba

Yoshiteru Oshima

et al.

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2024

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Cited by 1 publication

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Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Ramírez-Giraldo,

Avendaño-Morales,

Van-Londoño

et al. 2024

JCM

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Background: Although the current literature has shown an increasing interest in surgical treatment of gastric cancer (GC) in older adults in recent years, there is still no consensus on proper management in this subgroup of patients. This study was designed with the objective of evaluating the current evidence that compares limited lymph node dissection with extended lymph node dissection in older adult patients (≥65 years) coursing with resectable GC. Methods: A systematic review of PubMed, Cochrane library, and ScienceDirect was performed according to PRISMA guidelines. All studies before 2018 were selected using a systematic review by Mogal et al. Studies were eligible for this meta-analysis if they were randomized controlled trials or non-randomized comparative studies comparing limited lymph node dissection versus extended lymph node dissection in patients with resectable GC taken to gastrectomy. Results: Seventeen studies and a total of 5056 patients were included. There were not any statistically significant differences in OS (HR = 1.04, CI95% = 0.72–1.51), RFS (HR = 0.92, CI95% = 0.62–1.38), or CSS (HR = 1.24, CI95% = 0.74–2.10) between older adult patients taken to limited and extended lymphadenectomy in addition to gastrectomy as the current surgical treatment for GC. Although a higher rate of major complications was observed in the extended lymphadenectomy group, this difference was not statistically significant in incidence between both groups of patients (OR = 1.92, CI95% = 0.75–4.91). Conclusions: Limited lymphadenectomy must be considered as the better recommendation for surgical treatment for GC in older adult patients, considering the oncological outcomes and lower rates of complications compared with more radical lymph node dissections.

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Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Ramírez-Giraldo,

Avendaño-Morales,

Van-Londoño

et al. 2024

JCM

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Systematic review and meta-analysis of reports of patients with gastric cancer aged 80 years and older

Cited by 1 publication

References 17 publications

Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

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