Systematic review and meta‐analysis of mesenchymal stem/stromal cells therapy for impaired renal function in small animal models

Wang, Yan; He, Jun; Pei, Xiaohua; Zhao, Weihong

doi:10.1111/nep.12018

Cited by 97 publications

(81 citation statements)

References 30 publications

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“…Literature informs, for example, that stem/progenitor cells can be principally administered via the arterial or venous vessel system, by punctual injections into diseased parenchyma or by seeding in the space left between the organ capsule and the outer parenchyma [4,5]. The various results illustrate that irrespective of applied implantation technique the expectations have not been achieved yet.…”

Section: Introductionmentioning

confidence: 99%

Tannic acid label indicates abnormal cell development coinciding with regeneration of renal tubules

Minuth

Denk

2014

BMC Clin Pathol

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BackgroundStem/progenitor cells are in the focus of research as a future therapeutic option to stimulate regeneration in diseased renal parenchyma. However, current data indicate that successful seeding of implanted stem/progenitor cells is prevented by harmful interstitial fluid and altered extracellular matrix. To find out possible parameters for cell adaptation, the present investigation was performed.MethodsRenal stem/progenitor cells were mounted in an artificial interstitium for perfusion culture. Exposure to chemically defined but CO2-independent culture media was tested during 13 days. Cell biological features were then analyzed by histochemistry, while structural details were investigated by transmission electron microscopy after conventional and improved fixation of specimens.ResultsCulture of renal stem/progenitor cells as well in Leibovitz’s L-15 Medium as CO2 Independent Medium shows in fluorescence microscopy spatial development of numerous tubules. Specimens of both media fixed by conventional glutaraldehyde exhibit in electron microscopy a homogeneous cell population in developed tubules. In contrast, fixation by glutaraldehyde including tannic acid illuminates that dispersed dark marked cells of unknown function are present. The screening further demonstrates that the dark cell type does not comply with cells found in embryonic, maturing or matured renal parenchyma.ConclusionsThe actual data show that development of abnormal cell features must be taken into account, when regeneration of renal tubules is simulated under in vitro conditions.

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Section: Introductionmentioning

confidence: 99%

Tannic acid label indicates abnormal cell development coinciding with regeneration of renal tubules

Minuth

Denk

2014

BMC Clin Pathol

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“…Similarly, Wang et al [67] showed that transplanted BM-MSCs improved a wide variety of kidney disorders, from AKI to CKD, which further indicates that these cells are renoprotective after arterial delivery during the early stages of renal injury.…”

Section: Cell-based Approach: Cell Therapymentioning

confidence: 95%

Kidney diseases and tissue engineering

Moon

Yoo

et al. 2016

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“…In a systematic meta-analysis of 21 of these studies [3], the authors found a consistent reduction in serum creatinine (sCr) in MSC-treated animals versus controls. The studies differed in terms of time point and dose of MSC administered, time point of sCr measurement, route of MSC delivery, type of kidney injury and animal used (mice vs. rats).…”

Section: Mechanisms Of Msc Protection Against Acute Kidney Injurymentioning

confidence: 99%

Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury

Fleig

Humphreys²

2014

Nephron Clin Pract

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Hundreds of clinical trials are currently investigating the potential for mesenchymal stem cells (MSC) to treat human disease, including kidney disease. There is tremendous excitement over the therapeutic potential of this form of stem cell therapy and an improving understanding of how MSC act. This review will summarize our current knowledge concerning the mechanisms by which MSC accelerate kidney repair after acute injury. It will also survey the current MSC clinical trial landscape in nephrology. Finally, future challenges to a widespread application of MSC therapies for patients with kidney injury will be outlined.

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Systematic review and meta‐analysis of mesenchymal stem/stromal cells therapy for impaired renal function in small animal models

Cited by 97 publications

References 30 publications

Tannic acid label indicates abnormal cell development coinciding with regeneration of renal tubules

Tannic acid label indicates abnormal cell development coinciding with regeneration of renal tubules

Kidney diseases and tissue engineering

Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury

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