Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss

Ng, Ka Ying Bonnie; Cherian, G; Kermack, Alexandra J; Bailey, Sarah; Macklon, Nick S.; Sunkara, Sesh Kamal; Cheong, Ying

doi:10.1038/s41598-021-86445-2

Cited by 47 publications

(47 citation statements)

References 44 publications

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“…It was found that for every 100 mg/day increment of caffeine consumption, the risk of SAB was increased by 8% (RR = 1.08; 95% CI: 1.04-1.13) and stillbirth by 9% (RR = 1.09; 95% CI: 1.02-1.16). In a meta-analysis of 2 studies by Ng et al [47] it was shown that the risk of recurrent pregnancy loss in the group of women with higher caffeine consumption (> 99 mg/day) compared to the group with lower caffeine consumption (< 99 mg/day) was higher, but not statistically significant (OR = 1.35; 95% CI: 0.83-2. 19).…”

Section: Pregnancy Lossmentioning

confidence: 94%

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Surma

Witek

2022

Ginekol Pol

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Coffee is one of the most consumed beverages in the world. The impact of coffee consumption on human health has been the subject of many clinical studies and meta-analyses. Taking into account the results of these studies, it can be concluded that coffee has a number of health benefits in terms of the population, including the reduction of the risk of death from any cause. From a clinical point of view, the safety of coffee consumption in a specific subpopulation of pregnant women is important. A large percentage of women continue to consume this drink during pregnancy, while a significant proportion of them exceed the permissible daily dose of caffeine (≤ 200 mg). During pregnancy, the metabolism of caffeine slows down significantly, which prolongs its action and penetrates into the body of the fetus. These biochemical observations have become the driving force behind numerous clinical studies assessing the impact of coffee consumption during pregnancy on its course, complications and the health of the newborn. This review article summarizes the current knowledge of these important issues.

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Section: Pregnancy Lossmentioning

confidence: 94%

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Surma

Witek

2022

Ginekol Pol

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“…Etiological factors of RPL include advanced maternal age, immunological problems, endocrine dysfunction, and anomalies of maternal anatomy, chromosomes, and placenta [ 5 , 6 , 7 ]. Moreover, environmental factors such as infection, smoking, alcohol, psychological trauma, and stress may contribute to RPL [ 8 , 9 , 10 ]. However, the cause of RPL is unclear in 30–40% of cases, and recent studies suggest that genetic factors play an important role in the pathogenesis of idiopathic RPL [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association Study between Mucin 4 (MUC4) Polymorphisms and Idiopathic Recurrent Pregnancy Loss in a Korean Population

Kim

Park

Lee

et al. 2022

Genes

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Recurrent pregnancy loss (RPL) is the loss of two or more consecutive pregnancies before 20 weeks of gestational age. Our study investigated whether mucin 4 (MUC4) polymorphisms are associated with RPL. MUC polymorphisms (rs882605 C>A, rs1104760 A>G, rs2688513 A>G, rs2258447 C>T, and rs2291652 A>G) were genotyped in 374 women with RPL and 239 controls of Korean ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis and the TaqMan probe SNP genotyping assay. Differences in genotype frequencies between cases of RPL and the controls were compared. MUC4 rs882605 C>A and rs1104760 A>G polymorphisms were associated with increased incidence of RPL in three and four or more pregnancy loss patients. The haplotype analyses showed a tendency for the allelic effect including the association of MUC4 rs882605 A and rs1104760 G alleles with increased incidence of RPL. In addition, the MUC4 rs882605 CA/MUC4 rs2258447 CC genotype combination was associated with increased RPL prevalence. The two exonic polymorphisms lead to amino acid changes of protein and may act as pathogenic variants for RPL. In conclusion, the MUC4 rs882605 C>A and MUC4 rs1104760 A>G polymorphisms were associated with the susceptibility of RPL and we considered them as potential biomarkers for RPL.

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“…Although some women may be able to achieve pregnancy, they may not be able to maintain that pregnancy throughout gestation and deliver a live-born infant. SAB has an occurrence rate of approximately 10%, while that of recurrent SAB is approximately 5% (1). There are many factors that affect early pregnancy abortion.…”

Section: Introductionmentioning

confidence: 99%

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

Li¹,

Lv²,

Zhang³

et al. 2021

Ann Transl Med

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Background: As potential substitutes for polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants (OPFRs) have been frequently detected in the environment. They have been suggested to impair fetal growth and development in toxicological studies. However, there are few studies on their maternal effects before or during early pregnancy.Methods: This study was designed to investigate whether exposure to OPFRs before or during early pregnancy is associated with the risk of spontaneous abortion (SAB), using a nested case-control design based on the case data from clinical examinations in Shanghai, China. A total of 110 cases from this cohort project in 2019-2020 were included. The concentrations of OPFRs in maternal urine samples collected in early pregnancy were determined using Ultra high performance liquid chromatography-triple quadrupole mass spectrometer (UHPLC-MS/MS), and pregnancy outcomes were extracted from the medical records.Meanwhile, ultra high performance liquid chromatography time-of-flight mass spectrometer (UHPLC-Q-TOF/MS)-based metabonomics was used to obtain urine metabolic profiles of 110 women in early pregnancy.Results: According to the quantitative results, the content of bis(1-chloro-2-propyl)phosphate (BCIPP) in urine was significantly different between the SAB patients and the healthy pregnant women. Besides, metabolic profile analysis showed a significant difference in the urine metabolism profile in early pregnancy between SAB cases and controls. Twenty-five different metabolites were screened out, which showed different degrees of correlation with the urinary BCIPP concentration.Conclusions: Based on these results, it suggests that there may be a certain correlation between BCIPP concentration in the urine and the risk of SAB from a metabolomics perspective, and its effect may be related to the metabolism of tryptophan and fatty acids.

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Systematic review and meta-analysis of female lifestyle factors and risk of recurrent pregnancy loss

Cited by 47 publications

References 44 publications

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Coffee consumption during pregnancy — what the gynecologist should know? Review of the literature and clinical studies

Association Study between Mucin 4 (MUC4) Polymorphisms and Idiopathic Recurrent Pregnancy Loss in a Korean Population

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

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