Systematic review and meta-analysis of gallstone disease treatment outcomes in early cholecystectomy versus conservative management/delayed cholecystectomy

Bagepally, Bhavani Shankara; Haridoss, Madhumitha; Sasidharan, Akhil; Jagadeesh, Kayala Venkata; Oswal, Nikhil Kumar

doi:10.1136/bmjgast-2021-000675

Cited by 15 publications

(7 citation statements)

References 56 publications

(37 reference statements)

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“…A higher risk of surgical complications, wound infection and sepsis has been observed in cases with conservative treatment than early cholecystectomy. A systematic review conducted in India has also reported similar findings where early surgical method was preferred with reduction in hospital stay and pain due to gall stones 9 .…”

Section: Discussionmentioning

confidence: 73%

Early Cholecystectomy versus Conservative Management in Mucocele Gall Bladder

Kumar¹,

Afzal²,

Samee³

et al. 2023

PJMHS

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Aim: To compare the early cholecystectomy versus conservative management in mucocele gall bladder. Study design: Retrospective study Place and duration of study: Department of General Surgery, Ward-2, JPMC/Jinnah Sindh Medical University, Karachi from 1st October 2020 to 30th September 2022. Methodology: One hundred patients suffering from cholelithiasis with mucocele gall bladder were included. The patients were divided into two groups on the basis of stone location. Group 1 was those where the stone was found on the base of common bile duct (CBD) and elective/early surgery was conducted for the cases of cholelithiasis. Group 2 was those where conservative/delayed surgical technique was applied due to stone location not in the CBD for treatment. While in each group there were 50 cases which were age and gender matched. The first priority for surgical option was through laparoscopic surgery. Results: The mean age of the patients was 45.2±3.3 years. Out of the total cases in group 1 the process of ERCP was conducted in 64% of the cases before laparoscopy. There were 1% and 10% cases which were shifted to open surgery from laparoscopic in group1 and 2 respectively. Consequently, the mean operative time and hospital duration was increased in group 2. Within the Group 2 cases the risk of sepsis, wound contamination and perforation of gall bladder was much higher than in the Group 1 by a value of 10%, 12% and 6% respectively. There was 1 case of mortality and 2 cases of pancreatitis in group 2. Conclusion: The early cholecystectomy is a much safer and efficient procedure on treatment of mucocele gall bladder cases verses conservative management. Keywords: Early cholecystectomy, Conservative management, Mucocele gall bladder

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Section: Discussionmentioning

confidence: 73%

Early Cholecystectomy versus Conservative Management in Mucocele Gall Bladder

Kumar¹,

Afzal²,

Samee³

et al. 2023

PJMHS

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“…The prevalence of gallstones can vary widely across different populations and regions. Globally, gallstone prevalence varies from 0.1% to 50.5% (5). Indeed, gallstone-related complications encompass a range of conditions that can affect the biliary system and adjacent organs.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic cholecystectomy versus open cholecystectomy

Adil Mehmood,

Shao Ying Mei,

Abuduhaiwaier abuduhelili

et al. 2024

World J. Bio. Pharm. Health Sci.

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This review article provides a comparison of laparoscopic cholecystectomy (LC) versus open cholecystectomy (OC) for the treatment of gallbladder disease. Laparoscopic cholecystectomy, characterized by its minimally invasive approach, has gained popularity over open cholecystectomy due to its perceived advantages in safety, reduced postoperative pain, shorter hospital stays, improved cosmesis, and potential cost savings. However, the choice between the two procedures remains subjective and depends on various factors such as patient characteristics, surgical expertise, and specific clinical scenarios. This review synthesizes current evidence from clinical trials and studies to aid clinicians in making informed decisions regarding the selection of the most appropriate surgical approach for individual patients.

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“…Cholelithiasis (gallstone disease) is one of the most common diseases of the gastrointestinal tract worldwide [1][2][3], and gallbladder surgeries for gallstones are the most common procedures performed in general surgery [4]. The incidence of gallstones varies from 0.1% to 50.5% worldwide [5]. In Poland, it affects about 20% of the population [6], and about 45.000 cholecystectomies (surgical removal of the gallbladder) are performed annually [7].…”

Section: Introductionmentioning

confidence: 99%

Cholelithiasis – a particular threat to women. A review of risk factors

Lazarchuk,

Barzak,

Wozniak

et al. 2023

Medical Journal of Cell Biology

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In Poland, cholelithiasis affects approximately 20% of the population and require approximately 45.000 cholecystectomies per year. Women, especially mature women, are more at risk of developing this condition. Hormonal and reproductive factors are the reason for higher incidence in women. In this publication, we review significant factors affecting this situation. The anatomical structure of the gallbladder may have a significant impact on the course of the cholecystectomy, and the occurrence of any intra- or post-operative complications. The pathomechanism of cholelithiasis is described, as well as the basic risk factors.

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Systematic review and meta-analysis of gallstone disease treatment outcomes in early cholecystectomy versus conservative management/delayed cholecystectomy

Cited by 15 publications

References 56 publications

Early Cholecystectomy versus Conservative Management in Mucocele Gall Bladder

Early Cholecystectomy versus Conservative Management in Mucocele Gall Bladder

Laparoscopic cholecystectomy versus open cholecystectomy

Cholelithiasis – a particular threat to women. A review of risk factors

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