2019
DOI: 10.1007/s00228-019-02771-5
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Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity

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Cited by 38 publications
(28 citation statements)
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“…New strategies based on the co-administration of nephroprotectors are under development. Candidate nephroprotectors include magnesium formulations [ 6 , 9 ] and, most prominently, a variety of antioxidants [ 6 , 20 , 21 ]. Flavonoids are a family of nephroprotective polyphenolic products derived from vegetables, fruits, nuts, and wine, with strong antioxidant properties [ 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…New strategies based on the co-administration of nephroprotectors are under development. Candidate nephroprotectors include magnesium formulations [ 6 , 9 ] and, most prominently, a variety of antioxidants [ 6 , 20 , 21 ]. Flavonoids are a family of nephroprotective polyphenolic products derived from vegetables, fruits, nuts, and wine, with strong antioxidant properties [ 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…1 Patients that survive AKI are predisposed to develop chronic kidney disease (CKD). 2 Since there is a lack of an effective therapeutic approach for cisplatininduced AKI prevention and treatment, 3,4 risk factors that induce or promote AKI should be addressed during cisplatin treatment as carefully as possible.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, there was no significant difference on the body weight or survival rate between the control group and the ONP group, suggesting that ONP possibly had no obvious toxicity. The clinical application of DDP shows that nephrotoxicity is one of its main side effects and may even lead to death (Casanova et al., 2020; Charlier et al., 2004). Based on the attenuation of body weight loss and the increasing of survival rate in mice, ONP was likely to have the potential to protect the kidneys.…”
Section: Resultsmentioning
confidence: 99%