Systematic Review and Meta-analysis of Prevalence of Coronary Artery Disease in Adult Patients with Cardiac Myxomas

Abstract

Background: Studies have reported varied prevalence estimates of coronary artery disease (CAD) in cardiac myxoma patients. We performed a systematic review and meta-analysis of observational studies to summarize the point prevalence of CAD in adults with cardiac myxomas. Methods and Results: Two independent investigators searched MEDLINE and LILACS databases using the terms " Myxoma”, " Coronary Angiography" and " Coronary Disease" from inception through December 2014 for all relevant studies. We included 6 observational studies. Publication bias was evaluated through Egger's test and Trim and Fill method. A pooled estimate of CAD prevalence with corresponding 95% confidence interval (CI) was calculated based on a random-effects model. The pooled CAD prevalence in adult cardiac myxoma patients was 20.7% with low heterogeneity (I 2 = 14.86%). Conclusions: It is a matter of debate if preoperative coronary angiography must be done as a routine procedure. Although coronary disease and angiographically detectable neovascularity can alter surgical management, more studies are needed to evaluate this question.

MR imaging of primary benign cardiac tumors in the pediatric population

“…Mean age at diagnosis is 50 years, and approximately 70% occur in women [ 74 ]. When occurs in syndromic context, more common in young males, has a multifocal development with multisite origin [ 75 ].…”

Left atrial myxoma with coronary artery disease

“…A systematic review and meta-analysis of 109 patients with cardiac myxoma by Silva et al showed a CAD prevalence ranging from 5.3% to 36.3% with an average of 20.7%. 9 Patients with myxoma can present with constitutional symptoms, dyspnoea, angina, syncope or embolic manifestations. In addition, myxomas can present as myocardial infarction secondary to arterial embolisation.…”

“…Erdil et al found a 36% prevalence rate of CAD2 whereas Fueredi et al 7 and Velasco et al 8 reporting a higher prevalence (66.7% and 82%, respectively). A systematic review and meta-analysis of 109 patients with cardiac myxoma by Silva et al showed a CAD prevalence ranging from 5.3% to 36.3% with an average of 20.7% 9. Patients with myxoma can present with constitutional symptoms, dyspnoea, angina, syncope or embolic manifestations.…”

Large Left Atrial Myxoma Discovered During Restaging of Breast Cancer

“…Although extremely rare, myxomas are the most common cardiac tumors, accounting for more than 50% of all cases worldwide. 1 , 2 Despite being histologically benign, myxomas can have a wide spectrum of presentations based on their anatomic location, size, and mobility. They can mimic various heart conditions and present as cardiac insufficiency, valvular heart disease, syncope, peripheral embolic events, and systemic symptoms.…”