Systematic review and meta‐analysis of randomised, controlled trials on the effects of garlic supplementation on serum adiponectin and leptin levels

Abstract

Background: Our aim in this meta-analysis was to determine the effect of garlic supplementation on adiponectin and leptin serum levels.Method: A systematic search was conducted using PubMed, Scopus, ISI Web of Science and Cochrane Library for eligible trials up to November 2020. A fixed-effects model was used to pool calculated effect sizes.Results: Five trials were included in the overall analysis. Our analysis showed that garlic supplementation did not significantly affect adiponectin (Hedges's: 0.20; 95% CI: −0.06, 0.47; P-values = .12) and leptin (Hedges's: 0.08; 95% CI: −0.26, 0.41; Pvalues = .65) concentrations in comparison with placebo. However, in the subgroup analysis, significantly increased serum adiponectin level was seen following garlic supplementation in trials with a mean age of participants ˂30 years (Hedges's: 0.44; 95% CI: 0.01, 0.87; P-values = .04), the doses ˂1.5 g/d (Hedges's: 0.38; 95% CI: 0.02, 0.71; P-values = .04) and trials with duration ≥8 weeks (Hedges's: 0.48; 95% CI: 0.08, 0.89; P-values = .02). Conclusion:Overall, garlic supplementation could not change the circulatory adiponectin and leptin levels. Subgroup analyses showed a significant reduction in adiponectin levels in younger participants, longer duration and lower intervention dose.However, further studies are needed to confirm the present results.How to cite this article: Shekarchizadeh-Esfahani P, Hassani B, Roshanravan N, Sorraya N. Systematic review and metaanalysis of randomised, controlled trials on the effects of garlic supplementation on serum adiponectin and leptin levels. Int J

Soluble Fiber Effect on Human Serum Leptin and Adiponectin: A Systematic Review and Dose-Response Meta-Analysis

“…The previous documents have revealed that garlic may affect adipokines through antioxidant properties. For example, garlic increases the nitric oxide bioavailability via advancing the cellular antioxidant capacity by providing cellular thiol antioxidants like cysteine and diminished glutathione, maintaining the functionally appropriate concentration of tetrahydrobiopterin and controlling oxidative inactivation of tetrahydrobiopterin [ 51 52 ]. Thus, according to the mentioned mechanisms, the consumption of soluble fiber can be suggested to manage leptin levels and resistance among overweight or obese subjects.…”