Systematic Review and Pooled Estimates for the Diagnostic Accuracy of Serological Markers for Intestinal Ischemia

Evennett, Nicholas; Petrov, Maxim S.; Mittal, Anubhav; Windsor, John A.

doi:10.1007/s00268-009-0074-7

Cited by 229 publications

(209 citation statements)

References 63 publications

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“…Poeze et al 32 found that serum D-lactate is consistently increased in intestinal ischemia, with sensitivity and specificity of 82 and 72% respectively. Evennett et al 33 have also added to this point of view.…”

Section: Discussionmentioning

confidence: 99%

Combination of Serum C-reactive Protein and D-lactate: Predictors of Strangulation in Intestinal Obstruction

Pal¹,

Ansari²,

Islam³

2016

Panamerican Journal of Trauma, Critical Care &Amp; Emergency Surgery

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Introduction: Serum C-reactive protein (CRP) and D-lactate have been proposed as markers of intestinal ischemia. The purpose of this prospective observational study is to find whether serum CRP and serum D-lactate can help in predicting strangulation in cases of acute intestinal obstruction. Materials and methods:A total of 50 consecutive patients were included in the study after excluding patients of comorbid medical illness and patients with findings other than obstruction or strangulation. The serum values of CRP and D-lactate were measured and compared between obstruction with strangulation and obstruction without strangulation. Receiver operating characteristic (ROC) curve was drawn and cutoff values for the diagnosis of strangulation were calculated along with calculation of sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs).Results: A total of 14 patients who were diagnosed with strangulated bowel obstruction had significantly higher values of serum CRP and D-lactate when compared with 36 patients with simple bowel obstruction (116 vs 40 mg/L and 5.4 vs 2.7 mmol/L respectively, p < 0.05). Using ROC analysis, the area under the curve of serum CRP and D-lactate was found to be 0.785 and 0.775 respectively, for bowel strangulation. Using a cutoff value of 60 mg/L for CRP, the sensitivity, specificity, PPV, and NPV were 87.5, 58.3, 48.3, 91.3% respectively. Using a cutoff value of 4.5 mmol/L for D-lactate, the sensitivity, specificity, PPV, and NPV were 75.0, 69.4, 52.7, 86.2% respectively. Conclusion:Serum CRP and D-lactate can be useful and reasonable markers for predicting strangulation in cases of acute intestinal obstruction in an emergency setting.

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Section: Discussionmentioning

confidence: 99%

Combination of Serum C-reactive Protein and D-lactate: Predictors of Strangulation in Intestinal Obstruction

Pal¹,

Ansari²,

Islam³

2016

Panamerican Journal of Trauma, Critical Care &Amp; Emergency Surgery

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“…[2,11] In an earlier study [25] of RDW in the context of diagnosing AMI, cut-off value, sensitivity, and specificity were 15.04%, 40.8%, and 81.2%, respectively. Another study [26] found that the AUC for RDW was 0.713, and that the cut-off value was 14.85%.…”

Section: Discussionmentioning

confidence: 99%

“…During this process, inflammatory substances measurable in peripheral blood are released from necrotic cells of the gut wall. [2,6] Recent studies have focused on such materials because early and accurate detection of inflammation is essential in order to optimize treatment and prognosis of those with medical emergencies. [7] Several biomarkers, such as C-reactive protein (CRP), procalcitonin, and mean platelet volume (MPV) have been used as indicators of inflammation.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of the neutrophil-to-lymphocyte ratio in patients with acute mesenteric ischemia: A retrospective cohort study

Tanrıkulu

Sabuncuoğlu

et al. 2015

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute mesenteric ischemia (AMI) remains fatal in 50-70% of cases. AMI is recognized as a vascular emergency, requiring rapid and efficient clinical evaluation and treatment. In the present retrospective study, the possible utility of the neutrophillymphocyte ratio (NLR) in the early diagnosis of AMI was explored. The potential use of this ratio to distinguish AMI from non-vascular bowel necrosis (NVBN) was investigated.

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“…While many blood analyses, such as lactate dehydrogenase, transaminases, D-dimer, D-lactate, and creatinine phosphokinase have been suggested for diagnosis of AMI, as yet, none is sufficiently specific or sensitive. [3] Diagnosis can usually be made based The aim of the present study was to investigate the predictive value of MPI together with P/L ratio, a hematological marker, with respect to prognosis in patients with AMI.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors and Evaluation through Mannheim Peritonitis Index and Platelet-to-Lymphocyte Ratio in Acute Mesenteric Ischemia

Yılmaz

Cartı²

2017

Ulus Travma Acil Cerrahi Derg

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Systematic Review and Pooled Estimates for the Diagnostic Accuracy of Serological Markers for Intestinal Ischemia

Cited by 229 publications

References 63 publications

Combination of Serum C-reactive Protein and D-lactate: Predictors of Strangulation in Intestinal Obstruction

Combination of Serum C-reactive Protein and D-lactate: Predictors of Strangulation in Intestinal Obstruction

Diagnostic utility of the neutrophil-to-lymphocyte ratio in patients with acute mesenteric ischemia: A retrospective cohort study

Prognostic Factors and Evaluation through Mannheim Peritonitis Index and Platelet-to-Lymphocyte Ratio in Acute Mesenteric Ischemia

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