Systematic Review: Anticancer Potential of Active Compounds from Galangal (<i>Alpinia galanga</i>)

Suciati, Anugerah; Maryati,

doi:10.2991/978-94-6463-050-3_23

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…For many common childhood illnesses, such as asthma, fever, dyspepsia, bronchitis, diabetes mellitus, and irritations, the galangal plant’s tuber is used as a cough therapy ( Khairullah et al, 2020 ). Galangal rhizomes are used to treat aches and pains, colds, fever, diarrhea, heartburn or stomach pain, foul breath and body odor, severe thrush, sore throat, cough, and inflammation and to remove phlegm from bronchitis ( Suciati and Maryati, 2023 ). The seed is used to treat emaciation and clean the mouth.…”

Section: Distribution Taxonomy and Ethnopharmacological Usesmentioning

confidence: 99%

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavoring agents and in ethnomedicine to heal numerous diseases, including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of plants and their bioactive compounds on the different steps of the immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyze the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, namely, Zingiber officinale Roscoe, Z. cassumunar Roxb., Z. zerumbet (L.) Roscoe ex Sm., Alpinia galanga Linn., A. conchigera Griff, A. katsumadai Hayata, A. oxyphylla Miq., A. officinarum Hance, A. zerumbet (Pers.) Burtt. et Smith, and A. purpurata (Viell.) K. Schum. on the immune system, particularly via the inflammation-related signaling pathways. The immunomodulating activities of the crude extracts of the plants have been reported, but the constituents contributing to the activities have mostly not been identified. Among the extracts, Z. officinale extracts were the most investigated for their in vitro, in vivo, and clinical effects on the immune system. Among the bioactive metabolites, 6-, 8-, and 10-gingerols, 6-shogaol, and zerumbone from Zingiber species and cardamomin, 1′-acetoxychavicol acetate, yakuchinone, rutin, 1,8-cineole, and lectin from Alpinia species have demonstrated strong immunomodulating effects. More experimental studies using cell and animal models of immune-related disorders are necessary to further understand the underlying mechanisms, together with elaborate preclinical pharmacokinetics, pharmacodynamics, bioavailability, and toxicity studies. Many of these extracts and secondary metabolites are potential candidates for clinical development in immunomodulating agents or functional foods to prevent and treat chronic inflammatory disorders.

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Section: Distribution Taxonomy and Ethnopharmacological Usesmentioning

confidence: 99%

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

et al. 2023

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“…Numerous studies have documented the anticancer effect of compounds present in A. galanga [77][78][79]. Moreover, some of the A. galanga constituents also possess suppressive effects against skin cancer cells.…”

Section: Alpinia Galangamentioning

confidence: 99%

Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy

Baloghová,

Michalková,

Baranová

et al. 2023

Molecules

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Skin cancer is a condition characterized by the abnormal growth of skin cells, primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Different types of skin cancer include melanoma, basal cell carcinoma, and squamous cell carcinoma. Despite the advancements in targeted therapies, there is still a need for a safer, highly efficient approach to preventing and treating cutaneous malignancies. Spices have a rich history dating back thousands of years and are renowned for their ability to enhance the flavor, taste, and color of food. Derived from various plant parts like seeds, fruits, bark, roots, or flowers, spices are important culinary ingredients. However, their value extends beyond the culinary realm. Some spices contain bioactive compounds, including phenolic compounds, which are known for their significant biological effects. These compounds have attracted attention in scientific research due to their potential health benefits, including their possible role in disease prevention and treatment, such as cancer. This review focuses on examining the potential of spice-derived phenolic compounds as preventive or therapeutic agents for managing skin cancers. By compiling and analyzing the available knowledge, this review aims to provide insights that can guide future research in identifying new anticancer phytochemicals and uncovering additional mechanisms for combating skin cancer.

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Insights into the anticancer effects of galangal and galangin: A comprehensive review

Wu,

Luo,

2024

Phytomedicine

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Systematic Review: Anticancer Potential of Active Compounds from Galangal (Alpinia galanga)

Cited by 4 publications

References 33 publications

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy

Insights into the anticancer effects of galangal and galangin: A comprehensive review

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