Systematic review: gastric cancer incidence in pernicious anaemia

Vannella, Lucy; Lahner, Edith; Osborn, John; Annibale, Bruno

doi:10.1111/apt.12177

Cited by 182 publications

(131 citation statements)

References 38 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…These findings raise the question of the role of autoimmune gastritis in patients with T1-GCs and gastric cancer. A recent systematic review shows a pooled gastric cancer incidence rate in pernicious anemia of 0.27 % per person-years and an estimated nearly sevenfold relative risk of gastric cancer in pernicious anemia patients, thus strengthening the associated risk of gastric cancer in patients with autoimmune gastritis [43].…”

Section: Discussionmentioning

confidence: 99%

Gastric cancer in patients with type I gastric carcinoids

et al. 2014

View full text Add to dashboard Cite

Background Atrophic body gastritis (ABG) is associated with both type I gastric carcinoids (T1-GCs) and intestinaltype gastric cancer. The occurrence of gastric cancer in ABG patients with type I gastric carcinoids has not yet been described. Aim To describe the occurrence at follow-up of gastric cancer in ABG patients with type I gastric carcinoid in a retrospective case series in a single tertiary referral center. Methods Between 1994 and 2012, 17 new cases of T1-GCs were diagnosed among a cohort of ABG patients in a single tertiary referral center for ABG. The clinical charts of these 17 T1-GC patients were retrospectively evaluated for the occurrence of gastric cancer at follow-up (median 4.2 years, range 0.5-13). Results In 4 (23.5 %)/17 T1-GCs patients (3 females, age 40-78 years), gastric cancer occurred (median follow-up 5.9 years, range 5.1-13). Three cases were intestinal-type adenocarcinomas and one a signet-ring cell diffuse gastric cancer, localized in three cases in the antrum. In two patients, it was detected on random biopsies during followup gastroscopy; in the other two, gastroscopy was performed because of new symptoms. All patients with gastric cancer had associated autoimmune features (pernicious anemia, autoimmune thyroid disease and a spared antrum) compared to 77, 46 and 54 % of those without gastric cancer, although statistical significance was not reached. Conclusions This case series shows that in patients with T1-GCs, gastric cancer may frequently occur at long-term follow-up. Thus, these patients should be monitored by a long-term surveillance program, including an accurate bioptic sampling of the antral mucosa.

show abstract

Section: Discussionmentioning

confidence: 99%

Gastric cancer in patients with type I gastric carcinoids

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Recently, Vanella et al validated this association through a systematic review and meta-analysis, establishing that patients with pernicious anemia (vitamin B 12 deficiency) have a relative risk of developing gastric cancer of 6.8 (95% CI: 2.6-18.1) [133].…”

Section: H Pylori and Vitamin B 12 Deficiencymentioning

confidence: 99%

Helicobacter pylori and Hematologic Diseases

Campuzano-Maya¹

2016

Extradigestive Manifestations of Helicobacter Pylori Infection - An Overview

View full text Add to dashboard Cite

Helicobacter pylori infection is the most common infection of the human species, with developing countries displaying a marked disadvantage in contrast to developing countries. While H. pylori infection is asymptomatic in most infected individuals, it is intimately related to malignant diseases of the stomach, such as gastric cancer and gastric MALT lymphoma, as well as benign diseases, for example chronic gastritis and duodenal and gastric peptic ulcers. Since the discovery that gastric mucosa could be colonized by bacteria, evidence of greater than 50 extragastric manifestations has been reported, linking H. pylori infection and the development of diseases associated with cardiology, dermatology, endocrinology, obstetrics and gynecology, hematology, pneumology, neurology, odontology, ophthalmology, otorhinolaryngology, and pediatrics. This chapter presents the extragastric manifestations of H. pylori infection expressed through hematologic diseases; particularly those included in the international consensus, and discusses guidelines for the management of H. pylori infection, such as iron deficiency, vitamin B 12 (cobalamin) deficiency, and immune thrombocytopenia. Other manifestations reviewed include immune neutropenia, antiphospholipid syndrome, and plasma cell dyscrasias, such us monoclonal gammopathy of undetermined significance, multiple myeloma, and Henoch-Schönlein purpura.

show abstract

“…Pernicious anemia represents a two to six fold higher risk of gastric cancer [9,34]. The magnitude of this association varies according to the duration of disease and geographic location.…”

Section: Pernicious Anemiamentioning

confidence: 99%

“…The magnitude of this association varies according to the duration of disease and geographic location. Pernicious anemia increases also the risk of gastric carcinoid tumors, probably because of prolonged achlorhydria and the consequent hypergastrinemia and cell hyperplasia [34].…”

Section: Pernicious Anemiamentioning

confidence: 99%

Gastric Cancer: An Epidemiological Overview

Benbrahim¹,

Mekkaoui²,

Lahmidani³

et al. 2017

Epidemiology

View full text Add to dashboard Cite

Gastric cancer constitutes one of the leading causes of cancer incidence and mortality in the worldwide despite its decline over the past century. In this article we will first review descriptive epidemiology of gastric cancer. Next we will discuss its precursors and risk factors; the principal risk factors of stomach cancer are HP Infection, smoking, high salt intake and genetic factors. Finally we will discuss screening strategies and prevention of gastric cancer.

show abstract

Systematic review: gastric cancer incidence in pernicious anaemia

Abstract: SUMMARY BackgroundPernicious anaemia (PA) has an increased risk for gastric cancer (GC). It is not established whether PA patients need to undergo endoscopic/histological follow-up.

Cited by 182 publications

References 38 publications

Gastric cancer in patients with type I gastric carcinoids

Gastric cancer in patients with type I gastric carcinoids

Helicobacter pylori and Hematologic Diseases

Gastric Cancer: An Epidemiological Overview

Contact Info

Product

Resources

About