Systematic Review of Chinese Medicine for Miscarriage during Early Pregnancy

Li, Lü; Leung, Ping Chung; Chung, Tony Kwok Hung; Wang, Chi Chiu

doi:10.1155/2014/753856

Cited by 20 publications

(20 citation statements)

References 22 publications

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“…In other words, miscarriage is early pregnancy loss before 20th week of gestation, or 139 days, counting from the first day of the last normal menses [1]. Approximately 15 % of all clinically recognized pregnancies result in spontaneous loss and many pregnancies are lost before a woman realizes that she is pregnant.…”

Section: Introductionmentioning

confidence: 99%

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

Patki

Chauhan

2015

J Obstet Gynecol India

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Background The data on the prevalence of recurrent spontaneous miscarriage (RSM) in India are scarce. This study aimed to determine the prevalence of RSM in Indian females. Methods Female patients aged between 18 and 45 years with history of at least one spontaneous miscarriage were enrolled in the study. The probability of a subsequent miscarriage after the first, second, and third miscarriage was determined. The prevalence of RSM (defined as loss of C3 pregnancies of B20 weeks gestation each) between different age groups was compared using v 2 test. Binary logistic regression analysis was applied to determine any association between RSM and the presence of risk factors. Results Of the 2398 patients screened for eligibility, 767 (32 %) had a history of at least one spontaneous miscarriage. The prevalence of RSM among the 753 enrolled patients who satisfied the eligibility criteria in the study was 7.46 %. RSM was mostly recorded in the age group of C33 years (14.68 %, n = 32). In patients with RSM, the second and third miscarriages were more prevalent during 7th week to end of 11th week of gestation. The probability of having a subsequent miscarriage after the first, second, and third miscarriage was 0.25, 0.34, and 0.22, respectively. There was a significant association (p \ 0.05) between RSM and clotting disorders, immunological factors, infections, and genetic disorders. 123Conclusion The study revealed a higher prevalence of RSM among the Indian women as compared to western data. Age, clotting disorders, immunological factors, infections, and genetic disorders were the significant risk factors associated with RSM.

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Section: Introductionmentioning

confidence: 99%

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

Patki

Chauhan

2015

J Obstet Gynecol India

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“…Traditional Chinese medicine (TCM), considered gentle and safe, has long been used to treat infertility and miscarriages [ 20 , 21 ]. It has also exhibited effectiveness in improving embryonic implantation rates in IVF [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10

Han

Cai

2015

Evidence-Based Complementary and Alternative Medicine

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Controlled ovarian hyperstimulation (COH) is widely used in assisted reproductive technology (ART), but it often leads to precocious maturation of the endometrium such that it impairs embryonic implantation and limits pregnancy rates. Previous studies have shown the traditional Chinese medicine, the Zishen Yutai pill (ZYP), to be effective in treatment of threatened as well as recurrent miscarriages, and it can improve embryonic implantation rates in patients undergoing IVF treatment. In the present study, the ZYP has been found to ameliorate precocious endometrial maturation in a mouse model of different COH. Molecular evaluations, real-time PCR, relative RT-PCR, Western blotting, and immunohistochemistry have indicated that the ZYP increased the expression of HOXA10, an important marker of uterine receptivity. Elevation of HOXA10 led to further upregulation of its target gene, integrin β3, and downregulation of EMX2, two additional markers of uterine receptivity. In this way, the ZYP may mitigate COH-induced precocious maturation of the endometrium and improve uterine receptivity by upregulating HOXA10.

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“…The recent relaxation of the two-child policy in China has also contributed to this phenomenon. Therefore, investigating the etiology and pathogenesis of MA has become of great interest in the field of pre-natal diagnosis in China and abroad ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy

et al. 2019

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The success of a pregnancy relies on moderate trophoblast apoptosis. If the ‘inhibition-induction’ balance of apoptosis is broken, a pathological pregnancy may occur. Galectin-3 has an important role in numerous biological processes, including tumor cell apoptosis. However, the association between galectin-3 and missed abortion (MA) has remained elusive. In the present study, the mRNA and protein expression levels of galectin-3 in placental villi, and the apoptotic index of placental cells from patients with MA were assessed and compared with those in a normal spontaneous abortion group. The present study investigated the function of galectin-3 in the process of MA and the possible association between placental apoptosis and galectin-3 expression in MA patients. Furthermore, the role of galetin-3 in patients with MA at different times (<4 and >4 weeks) was explored. The present study provided a potential mechanism of MA from a perspective of apoptosis and also provided potential therapeutic approaches to prevent MA.

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Systematic Review of Chinese Medicine for Miscarriage during Early Pregnancy

Cited by 20 publications

References 22 publications

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

An Epidemiology Study to Determine the Prevalence and Risk Factors Associated with Recurrent Spontaneous Miscarriage in India

Traditional Chinese Medicine, the Zishen Yutai Pill, Ameliorates Precocious Endometrial Maturation Induced by Controlled Ovarian Hyperstimulation and Improves Uterine Receptivity via Upregulation of HOXA10

Expression of galectin‑3 and apoptosis in placental villi from patients with missed abortion during early pregnancy

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