Systematic review of diagnostic criteria for IBS demonstrates poor validity and utilization of Rome III

Abstract

This review identified that comparator groups varied widely between studies making comparison of criteria impossible. Manning criteria are the most valid and accurate criteria. More importantly, Rome III is not validated and is poorly adopted in clinical research trial enrollment.

Validation of the Rome III Criteria for the Diagnosis of Irritable Bowel Syndrome in Secondary Care

“…38 More recently, a study from Denmark has attempted to examine the accuracy of the Rome III criteria for IBS, 39 compared with a reference standard of a primary care physician's diagnosis of IBS. Among 499 patients with suspected IBS the Rome III criteria were fulfilled by 376, yielding a sensitivity of 75%, similar to that we observed.…”

Irritable Bowel Syndrome: A Global Challenge Among Medical Students

“…Revision of Rome's criteria was introduced in 1992, 2000, and 2007 for Rome I, Rome II, and Rome III, respectively [15]. The Manning criteria, published in 1979, states that at least three positive findings of gastrointestinal symptoms should be present to diagnose IBS [16].…”

Reizdarmsyndrom – Diagnostik und Therapie

“…Die Praxis einer kriterienbasierten RDS-Diagnose ist nicht unumstritten [22]. So hatten in Validierungsstudien die Manning-Kriterien meist moderate Sensitivität (58%-94%) und Spezifität (55%-93%) [8]. Validierungsstudien bezüglich der Rom I-III Kriterien sind nur spärlich vorhanden [8]; eine kürzlich publizierte Arbeit zeigte eine Sensitivität der aktuell gebräuchlichen Rom III Kriterien (Tabelle 1) für die Diagnose eines RDS durch Allgemeinpraktiker von 75% [11].…”