Systematic review of EEG findings in 617 patients diagnosed with COVID-19

Antony, Arun; Haneef, Zulfi

doi:10.1016/j.seizure.2020.10.014

Cited by 136 publications

(159 citation statements)

References 47 publications

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“…This adds to evolving literature indicating that seizures comprise a relatively small percentage of patients undergoing cvEEG monitoring in the setting of COVID-19 illness ( 13 , 14 ). Moreover, findings on interictal EEG such as focal slowing and epileptiform discharges appear to increase the likelihood of also recording electrographic seizures in this population.…”

Section: Discussionmentioning

confidence: 65%

Incidence of Electrographic Seizures in Patients With COVID-19

et al. 2021

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Critical illness and sepsis are commonly associated with subclinical seizures. COVID-19 frequently causes severe critical illness, but the incidence of electrographic seizures in patients with COVID-19 has been reported to be low. This retrospective case series assessed the incidence of and risks for electrographic seizures in patients hospitalized with COVID-19 who underwent continuous video electroencephalography monitoring (cvEEG) between March 1st, 2020 and June 30th, 2020. One hundred and twenty-two patients were initially identified who resulted SARS-CoV-2 nasopharyngeal RT-PCR swab positivity with any electroencephalography order placed in the EMR. Seventy-nine patients met study inclusion criteria: age ≥18 years, >1 h of cvEEG monitoring, and positive SARS-CoV-2 nasopharyngeal swab PCR. Six (8%) of the 79 patients suffered electrographic seizures (ES), three of whom suffered non-convulsive status epilepticus. Acute hyperkinetic movements were the most common reason for cvEEG in patients with ES (84%). None of the patients undergoing cvEEG for persistent coma (29% of all patients) had ES. Focal slowing (67 vs. 10%), sporadic interictal epileptiform discharges (EDs; 33 vs. 6%), and periodic/rhythmic EDs (67 vs. 1%) were proportionally more frequent among patients with electrographic seizures than those without these seizures. While 15% of patients without ES had generalized periodic discharges (GPDs) with triphasic morphology on EEG, none of the patients with ES had this pattern. Further study is required to assess the predictive values of these risk factors on electrographic seizure incidence and subsequent outcomes.

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Section: Discussionmentioning

confidence: 65%

Incidence of Electrographic Seizures in Patients With COVID-19

et al. 2021

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“…Two systematic review studies with similar clinical questions have been previously reported [32] , [33] . Our meta-analysis provided additional value to those studies.…”

Section: Discussionmentioning

confidence: 83%

Meta-analysis of EEG findings in patients with COVID-19

Kubota

Gajera

Kuroda

2021

Epilepsy & Behavior

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“…COVID-19 patients displaying general states of confusion, agitation, unconsciousness altered mental state and seizure have prompted diagnostic testing [ 136 , 137 ]. Upon receiving a electroencephalograph, a common diagnostic tool for encephalopathy, 21% were indicative of encephalopathy [ 136 ].…”

Section: Sars-cov-2 Infection Of the Nervous Systemmentioning

confidence: 99%

“…This diagnosis increased to 74% in critical patients [ 138 ]. The most common background abnormality and the site was diffuse slowing and the frontal region, respectively [ 137 ]. Awareness of the symptoms of encephalopathy and diagnostic testing is important as the diagnosis is associated with a worse functional outcome and increase in mortality [ 134 ].…”

Section: Sars-cov-2 Infection Of the Nervous Systemmentioning

confidence: 99%