Systematic Review of Efficacy and Safety of Dulaglutide Compared With Other Antidiabetic Drugs

Abstract

A199sion (hazard ratio) and the binary logistic regression (odds ratio). Several sensitivity analyses were conducted including controlling for time-dependent covariates and using propensity score covariate adjustment. Results: The proportion (3.4%) of statin users (N= 53,212) who had incident diabetes was higher compared to the proportion (1.2%) of non-statin users (N= 53,212) who had incident diabetes. Compared to no statin use and controlling for demographic and clinical covariates, statin use was significantly associated with increased risk of incident diabetes (hazard ratio= 2.01; 99% C.I.= 1.74 -2.33; p< 0.0001). In addition, risk of diabetes was highest, respectively, among users of lovastatin, atorvastatin, simvastatin, and fluvastatin. Diabetes risk was lowest among pravastatin and rosuvastatin users. ConClusions: Because the potential for diabetogenicity differs among different statin types, health care professionals should individualize statin therapy by identifying patients who would benefit more from less diabetogenic statin types.