Systematic review of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis

Borab, Zachary; Mirmanesh, Michael; Gantz, Madeleine; Cusano, A.; Pu, Lee Li-Qun

doi:10.1016/j.bjps.2016.11.024

Cited by 40 publications

(18 citation statements)

References 24 publications

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“…Mitochondrial state LEAK is oxygen consumption compensating for proton leak, proton slip, electron leak, and cation cycling (Gnaiger 2014). It reflects mitochondrial coupling efficiency and production of reactive oxygen species (ROS;Jastroch et al 2010) and may account for 38 % of the basal metabolic rate in mammals (Brand et al 1994).…”

Section: Discussionmentioning

confidence: 99%

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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Hyperbaric oxygen (HBO) therapy, i.e. breathing pure oxygen under increased environmental pressures serves as a treatment for diverse medical conditions. However, elevated oxygen concentration can be detrimental to central nervous system or lungs. Our study aimed to evaluate the effects of repeated exposure to HBO on mitochondrial respiration assessed by high-resolution respirometry (HRR), cell viability estimated by PrestoBlue® reaction, morphology analyzed by routine phase contrast and fluorescent microscopy, and superoxide dismutase (SOD) and citrate synthase (CS) activities using human lung fibroblasts. The cells were exposed to HBO for 2 h per day for 5 consecutive days. One day after the last exposure, HBO cells displayed significantly smaller area and perimeter, compromised viability and elevated SOD activity. No changes were detected in CS activity or quality of mitochondrial network. HRR revealed impaired mitochondrial oxygen consumption manifested by increased leak respiration, decreased activity of complex II and compromised ATP-related oxygen consumption when fatty acids were oxidized. Our findings document that in conditions mimicking chronic intermittent exposure to HBO, lung fibroblasts suffer from compromised mitochondrial respiration linked to complex II and impaired cellular growth in spite of increased antioxidant defense. Underlying mechanism of this HBO-induced mitochondrial dysfunction should be further explored.

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Section: Discussionmentioning

confidence: 99%

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Dejmek

Kohoutová²,

Kripnerová³

et al. 2018

Physiol Res

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“…Despite all of the evidence of HBOT’s positive effects, its clinical value is still yet under discussion (see Dulai et al, 2014 ; An et al, 2015 ; Fox et al, 2015 ; Goldfarb et al, 2016 ; Chong and Rice, 2016 ; Borab et al, 2017 ). One difficulty of assessing the positive effects of HBOT in both experimental and clinical use includes the lack of standardized treatment protocols.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

et al. 2018

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Hyperbaric oxygen therapy (HBOT) is effective for the medical treatment of diverse diseases, infections, and tissue injury. In fact, in recent years there is growing evidence on the beneficial effect of HBOT on non-healing ischemic wounds. However, there is still yet discussion on how this treatment could benefit from combination with regenerative medicine strategies. Here we analyzed the effects of HBOT on three specific aspects of tissue growth, maintenance, and regeneration: (i) modulation of adult rodent (Mus musculus) intestinal stem cell turnover rates; (ii) angiogenesis dynamics during the development of the chorio-allantoic membrane (CAM) in Gallus gallus embryos; (iii) and wound-healing in a spontaneous type II diabetic mouse model with a low capacity to regenerate skin. To analyze these aspects of tissue growth, maintenance, and regeneration, we used HBOT alone or in combination with cellular therapy. Specifically, Wharton Jelly Mesenchymal Stem cells (WJ-MSC) were embedded in a commercial collagen-scaffold. HBOT did not affect the metabolic rate of adult mice nor of chicken embryos. Notwithstanding, HBOT modified the proliferation rate of stem cells in the mice small intestinal crypts, increased angiogenesis in the CAM, and improved wound-healing and tissue repair in diabetic mice. Moreover, our study demonstrates that combining stem cell therapy and HBOT has a collaborative effect on wound-healing. In summary, our data underscore the importance of oxygen tension as a regulator of stem cell biology and support the potential use of oxygenation in clinical treatments.

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“…Some data may be drawn from experience with external beam radiotherapy (EBRT), where skin radiation burns are not uncommon. For example, hyperbaric oxygen treatment, which is an effective therapy for EBRT burns [ 8 ], can be successfully employed in managing RSV complications [ 4 ]. However, the type and energy of ionizing radiation differ significantly between EBRT and RSV, with high-energy (up to 25 MeV) [ 9 ], high-penetration X-rays in the first, and lower energy (up to 2.2 MeV) [ 5 ], low-penetration β-particles in the latter.…”

Section: Discussionmentioning

confidence: 99%

Beta burns following radionuclide synovectomy

Chojnowski

Płazińska

Chojnowski³

et al. 2018

Reumatologia

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Radionuclide synovectomy (RSV) is a form of minimally invasive treatment of persistent joint inflammation. The procedure has a high safety profile and the occurrence of serious adverse events, such as full-thickness skin radiation necrosis, is rare. Less severe radiation events, while more common, are usually benign and self-limiting.We present two cases of low-grade beta burns that developed after RSV, despite proper injection technique. The potential long-term risk of such exposure is also discussed, with reference to historical radiation incidents. While low-grade beta burns after RSV usually pose little danger to the patient, any clinician involved in radionuclide treatment of arthritis should be aware of their existence and management

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Systematic review of hyperbaric oxygen therapy for the treatment of radiation-induced skin necrosis

Cited by 40 publications

References 24 publications

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Repeated Exposure to Hyperbaric Hyperoxia Affects Mitochondrial Functions of the Lung Fibroblasts

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice

Beta burns following radionuclide synovectomy

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