Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines

Corrêa, Maria Elvira P.; Cheng, Karis Kin Fong; Chiang, Karen; Kandwal, Abhishek; Loprinzi, Charles L.; Mori, Takehiko; Potting, Carin; Rouleau, Tanya; Toro, Juan J.; Ranna, Vinisha; Vaddi, Anusha; Peterson, Douglas E.; Bossi, Paolo; Lalla, Rajesh V.; Sharon, Elad

doi:10.1007/s00520-019-05217-x

Cited by 73 publications

(55 citation statements)

References 51 publications

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“…Preventive treatments recommended in international guidelines are oral cryotherapy (OC), recombined human keratinocyte growth factor and low-level laser therapy [ 12 ]. OC, the cooling of the mouth with ice during chemotherapy infusions, is a cost-effective and safe treatment with few adverse events and is recommended for patients receiving chemotherapy with short half-lives such as 5-FU or high-dose melphalan prior to a hematopoietic stem cell transplantation [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Primary evaluation of an air-cooling device to reduce oral mucositis: a pilot study in healthy volunteers

et al. 2020

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Oral mucositis is a common side effect of chemo and radiotherapy causing painful ulcers in the oral mucosa. One of the preventive treatments recommended in international guidelines is oral cryotherapy (OC). Randomized clinical trials on OC have used ice and ice-chips to cool the mouth, but this cooling method can be difficult for the patients to tolerate. Studies have shown that OC with ice for a period of 60 min reduces the oral temperature by 12.9 °C. The aim of this pilot study was to evaluate the temperature reduction and tolerability of OC using an intra-oral air-cooling (IOAC) device in healthy volunteers. Twelve healthy volunteers, mean age 35.4 years, were included in the study. They were treated with OC using the IOAC device for 60 min. Measurements of temperature were obtained at baseline, 5 and 60 min using a FLIR® C2 camera. After the OC session, tolerability and adverse events were documented using a questionnaire. All participants were able to use the device for 60 min. The overall temperature reduction after 5 min of OC was 10.7°C (p < 0.01) and after 60 min 14.5°C (p < 0.01). The most common adverse events were bad fit of the mouthpiece (n = 6), hypersalivation (n = 6), and difficulties swallowing (n = 5). The oral device reduced the temperature of the oral mucosa as much as treatment with ice with tolerable adverse events. The mouthpiece will be remodeled to improve tolerability before further studies are conducted.

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Section: Introductionmentioning

confidence: 99%

Primary evaluation of an air-cooling device to reduce oral mucositis: a pilot study in healthy volunteers

et al. 2020

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“…For more detailed results, including lists of all reviewed articles, please refer to the published article for each section. [11][12][13][14][15][16][17][18] Guidelines that are new or were changed compared with the 2014 guidelines are discussed below and appear in Table 1. Guidelines for which there was new evidence but the statements remained unchanged appear in Table 1 only.…”

Section: Resultsmentioning

confidence: 99%

“…These differences have been clarified in the detailed articles. [11][12][13][14][15][16][17][18]27 Furthermore, some of the interventions may only be available in certain geographic areas (eg, certain herbal compounds) or may have different regulations determined by local drug agencies (eg, PBM). Economic challenges also may play a role in the selection of the preferred treatment.…”

Section: Discussionmentioning

confidence: 99%

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Lalla

Bowen

Barasch

et al. 2020

Cancer

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Background Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis. Methods The literature was reviewed systematically to identify interventions for mucositis. Studies were rated according to the presence of major and minor flaws according to previously published criteria. The body of evidence for each intervention and in each treatment setting was assigned a level of evidence based on previously published criteria. Guidelines were developed based on the level of evidence, with 3 possible guideline determinations: recommendation, suggestion, or no guideline possible. Results The guideline covers evidence from 1197 publications related to oral or gastrointestinal mucositis. Thirteen new guidelines were developed for or against the use of various interventions in specific treatment settings, and 11 previous guidelines were confirmed after aa review of new evidence. Thirteen previously established guidelines were carried over because there was no new evidence for these interventions. Conclusions The updated MASCC/ISOO Clinical Practice Guidelines for mucositis provide professional health caregivers with a clinical setting‐specific, evidence‐based tool to help with the management of mucositis in patients who have cancer.

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“…This issue includes another set of articles that are part of the update for the MASCC/ISOO clinical practice guidelines for the management of mucositis. This set focuses on the following topics: growth factors and cytokines [8], antimicrobials, mucosal coating agents, anesthetics, and analgesics [9], cryotherapy [10], and natural and miscellaneous agents [11]. For each of these topics, the literature was reviewed systematically, and new evidence was merged with the evidence published in the previous guideline update [12].…”

mentioning

confidence: 99%

Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines

Cited by 73 publications

References 51 publications

Primary evaluation of an air-cooling device to reduce oral mucositis: a pilot study in healthy volunteers

Primary evaluation of an air-cooling device to reduce oral mucositis: a pilot study in healthy volunteers

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

The MASCC/ISOO mucositis guidelines 2019: the second set of articles and future directions

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