Systematic review of outcomes of patients undergoing resection for colorectal liver metastases in the setting of extra hepatic disease

Liver resection in patients with synchronous colorectal liver and lung metastases

“…This study also found that patients with resected lung metastases had the best outcome compared with patients who had other sites of extrahepatic disease (lung MS at 45 months, lymph nodes at 26 months, and peritoneal disease at 29 months). Those with a lower tumor burden were also found to have a better OS (Hwang et al, 2014).…”

“…Since resection of lung metastases in patients with CRC has a more favorable outcome than that of lymph node or peritoneal disease, there has been an increased interest in taking a surgical approach to patients with liver (Table 2) and lung (Table 3) CRC metastases (Maithel et al, 2010;Hwang et al, 2014). Studies have continued to show that as- (47) 38 (85) 28 (271) Note.…”

“…CLM = colorectal liver metastases; EHD = extrahepatic disease; MS = median survival; OS = overall survival. Information from Hwang et al (2014).…”

“…The patients were limited to systemic chemotherapy with or without liver-directed therapies (Hwang et al, 2014). Over the past few decades, there have been continued advancements in available therapies for pa-tients with stage IV CRC.…”

“…Hwang et al (2014) looked at 3,481 patients with CLM and extrahepatic metastatic disease involving the lungs, lymph nodes, peritoneum, and other sites (ovaries, bone, spleen, adrenal gland, vagina, and pancreas; Table 1). Of these patients, 78% had an R0 resection (complete resection with negative margins).…”