Systematic review of preservation TMS that includes continuation, maintenance, relapse-prevention, and rescue TMS

Wilson, Saydra; Croarkin, Paul E.; Aaronson, Scott T.; Carpenter, Linda L.; Cochran, Michelle; Stultz, Debra J.; Kozel, F. Andrew

doi:10.1016/j.jad.2021.09.040

Cited by 21 publications

(20 citation statements)

References 47 publications

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“…In addition, it shows that the effects can last up to 6 weeks in some animals. Interestingly, the data also show considerable variability in the duration of treatment effects in agreement with what is observed in the human population, particularly in patients receiving rTMS treatment for depression [ 30 ]. This highlights the need to be able to stratify tinnitus populations not only to optimize therapeutic outcomes, but also to identify the optimal regime for maintenance treatments to sustain therapeutic effects as long as possible.…”

Section: Discussionsupporting

confidence: 76%

“…In conclusion, our data support the therapeutic use of high-frequency rTMS stimulation over PFC for individuals with tinnitus. In addition, our data suggest that effects may be long lasting in some individuals, but others may benefit from ongoing maintenance treatments to sustain therapeutic effects [ 30 ]. It is important to note that an animal study is not affected by possible placebo effects, since an animal would not be experiencing the perceptions and expectations that a human tinnitus patient would have when receiving treatment.…”

Section: Discussionmentioning

confidence: 99%

“…rTMS-induced responses depend on physical and biological parameters, including coil characteristics, stimulation pattern, frequency and intensity [ 24 ]. Studies in tinnitus patients have shown some success in alleviating tinnitus symptoms with most focusing on the stimulation of the auditory cortex/temporal regions and/or the PFC [ 25 , 26 , 27 ], although evidence for a beneficial effect remains limited and it is unclear how long effects may persist after the completion of treatment [ 28 , 29 , 30 ]. A better understanding of the persistence of therapeutic effects of rTMS in the treatment of tinnitus is therefore required and is the focus of this study.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model

et al. 2022

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The auditory phantom sensation of tinnitus is associated with neural hyperactivity. Modulating this hyperactivity using repetitive transcranial magnetic stimulation (rTMS) has shown beneficial effects in human studies. Previously, we investigated rTMS in a tinnitus animal model and showed that rTMS over prefrontal cortex (PFC) attenuated tinnitus soon after treatment, likely via indirect effects on auditory pathways. Here, we explored the duration of these beneficial effects. Acoustic trauma was used to induce hearing loss and tinnitus in guinea pigs. Once tinnitus developed, high-frequency (20 Hz), high-intensity rTMS was applied over PFC for two weeks (weekdays only; 10 min/day). Behavioral signs of tinnitus were monitored for 6 weeks after treatment ended. Tinnitus developed in 77% of animals between 13 and 60 days post-trauma. rTMS treatment significantly reduced the signs of tinnitus at 1 week on a group level, but individual responses varied greatly at week 2 until week 6. Three (33%) of the animals showed the attenuation of tinnitus for the full 6 weeks, 45% for 1–4 weeks and 22% were non-responders. This study provides further support for the efficacy of high-frequency repetitive stimulation over the PFC as a therapeutic tool for tinnitus, but also highlights individual variation observed in human studies.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model

et al. 2022

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“…A revisão sistemática de Soleimani et al, (2016), que incorporou 15 estudos, mostrou que o tratamento com EMTr teve um efeito significativo no zumbido. Enquanto a revisão sistemática mais recente de Wilson et al, (2022), apenas refere que no geral, a qualidade da literatura existente é baixa em relação à eficácia, no entanto, forneceu suporte claro para eficácia e segurança em uma variedade de protocolos de EMTr.…”

Section: Estimulacão Magnética Transcraniana Repetitiva (Emtr)unclassified

Opções De Tratamento Para Zumbido: Revisão De Literatura

Bazoni¹,

Rocha²,

Freitas³

2022

Tópicos Essenciais Sobre a Saúde Humana

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O conceito mais amplo de saúde é o equilíbrio dinâmico, entre o organismo e seu ambiente, mantendo as características estruturais e funcionais do organismo nos limites considerados normais para o seu ciclo vital. Mas a definição de saúde requer outros pontos de vista: legal, social e econômico. Esta é definida pela Organização mundial de Saúde (OMS), como 'o estado de completo bem-estar físico, mental e social, e não apenas a ausência de doenças'. Ou seja, chegamos a uma questão simples, mas paradoxal: alguém no nosso país tem saúde? Parece-nos que, por melhor que sejam as condições de vida do indivíduo, é possível que ele não goze plenamente de saúde. Pois mesmo morando em uma mansão, mas se estiver psicologicamente abalado com a queda da Bolsa de Valores, não terá saúde. Assim, saúde aparenta ser um estado momentâneo e até mesmo fugaz. Então, devemos nos ater no prolongamento deste estado de saúde, pois nos parece impossível ter na prática saúde plena. Dito isso, é preciso incentivar estudos que tragam contribuições, por menores que sejam para a melhoria da qualidade de vida das pessoas. Deste modo, devemos focar nos pilares dessa saúde: a alimentação e a higiene, que pode prevenir doenças e agravos. Esta obra trás um pouco de algumas áreas das Ciências da Saúde, como amostra do quão complexo é essa área do conhecimento, principalmente quando aplicada à saúde humana.

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“…In addition to patients suffering acute major depressive disorder (MDD), who receive an acute course and move on, we serve patients with relapsing, treatment resistant depression. Wilson et al (2021) report that such patients can benefit from various on-going schedules of TMS and coined the term: "preservation TMS." In our experience a small proportion of patients remain in contact for some years -receiving a combination of (1) acute courses (20-30 treatments), (2) rescue courses (10 treatments), and (3) maintenance courses (5 treatments over 2.5-5 days, once every 4-8 weeks).…”

Section: Introductionmentioning

confidence: 99%

Resting Motor Threshold (RMT) during “Preservation” Transcranial Magnetic Stimulation (TMS)

2022

Am. J. Med. Res.

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RMT is central to therapeutic TMS. Routine clinical checks may reveal changes and some research has reported changes. It is unclear whether long-term preservation TMS treatment produces accumulative/permanent change in RMT of clinical concern. Our aim was to examine RMT records of participants in preservation TMS for any evidence of possible accumulative/permanent RMT change. The records were accessed of 30 females and 10 males who had received preservation TMS for from 24 to 57 (male) and 60 (female) months. Generalized estimating equations were used to explore trajectories of RMT over time for the overall sample and by age and gender. Some individual records displayed occasional sharp (up or down) spikes, frequently followed by a degree of rectification. The records of the three highest (mean 75.8) and lowest (mean 36.1) RMT scores were free of large variations. There were no significant changes in RMT over time for the total group, or by gender or age. For this group of 40 patients receiving long term TMS, there were no significant changes in the RMT.

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Systematic review of preservation TMS that includes continuation, maintenance, relapse-prevention, and rescue TMS

Cited by 21 publications

References 47 publications

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model

Long-Term Effects of Repetitive Transcranial Magnetic Stimulation on Tinnitus in a Guinea Pig Model

Opções De Tratamento Para Zumbido: Revisão De Literatura

Resting Motor Threshold (RMT) during “Preservation” Transcranial Magnetic Stimulation (TMS)

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