Systematic Review of Prevalence Studies and Familial Aggregation in Vestibular Migraine

Abstract

Background: Vestibular migraine (VM) is complex disorder consisting of episodes of migraine and vertigo with an estimated prevalence of 1-3%. As migraine, it is considered that VM has genetic predisposition; however, evidence to support a genetic contribution has not been critically appraised. Objective: The aim of this systematic review is to assess available evidence in scientific publications to determine the role of inheritance in VM. Methods: After performing the quality assessment of the retrieved records, 31 studies were included (24 epidemiological reports and 7 genetic association studies in families or case-control in candidate genes). We gathered data about prevalence of VM in different populations and in families, and also about the genetic findings reported. In addition, other variables were considered to assess the heritability of VM, such as the ancestry, the age of onset or the familial history of vertigo and migraine. Results: The estimated prevalence of VM was different between black (3.13%), white (2.64%) and Asian (1.07%) ethnicities. The reported prevalence of VM in migraine patients is higher in European countries (21%) than in Asian countries (10%). Moreover, the prevalence of the migraine-vertigo association in families is 4-10 times higher than the prevalence reported in the general population (sibling recurrence risk ratio λ s = 4.31-10.42). We also found that the age of onset is lower in patients with simultaneous onset of symptoms and in those who have familial history for migraine and/or vertigo, suggesting anticipation. Although some genetic studies have reported few allelic variants associated to MV, replication studies are needed to validate these results. Conclusions: The available evidence to support heritability in VM is limited. Variability in prevalence depending on ethnicity and geographic location suggests a combined genetic and environmental contribution to VM. However, the familial aggregation observed in VM support genetic and shared familial environmental effects that remarks the necessity of twins and adoptees-based epidemiological studies to estimate its heritability.

Recurrent Vestibular Symptoms Not Otherwise Specified: Clinical Characteristics Compared With Vestibular Migraine and Menière's Disease

“…Finally, the familial history of auditory or vestibular symptoms was not obtained in the present study. However, both VM and MD show a significant familial aggregation (41,42), and families with either VM or MD may have individuals with partial syndromes that could fit in the diagnosis of RVS-NOS. Future studies should investigate familial aggregation of RVS-NOS and VM.…”

Migraine in university students: A systematic review and meta‐analysis

“…Of the studies >50%, one reported vestibular migraine and one reported menstrual migraine. General population VM prevalence is estimated between 1 and 3% (Paz‐Tamayo et al, 2020), whilst MM affects about 20‐25% of female migraineurs (Vetvik & MacGregor, 2021). Potential reasons for the >50% prevalence rates in the studies within the current review include financial incentivization and a self‐report survey via Facebook (Abouzari et al, 2020), and in Tavares et al, 2021; inclusion of females at the peak of reproductive age (18–28 years old).…”

Vestibular Migraine

“…In both familial and non-familial cases of VM, there was a female predominance in most of the studies included in systematic review [13]. The mean age of onset of VM in patients with concurrent migraine and vertigo manifestation was found to be 22.7 ± 10.4 years, whereas patients with a non-simultaneous presentation of symptoms were somewhat older, with a mean age of onset for vertigo of 35.6 ± 12.4 years and 24 ± 8.9 years for migraine [18].…”