Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma

Key, Seraphina; Chia, Clemente; Hasan, Zubair; Sundaresan, Puma; Dwivedi, Raghav C.; Riffat, Faruque

doi:10.1016/j.oraloncology.2022.106052

Cited by 11 publications

(7 citation statements)

References 53 publications

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“…The recent retrospective study by Choi et al 14 comparing malignancy and recurrence of pleomorphic adenoma found no evidence that relapse or repeated surgeries promote malignant transformation of the tumor. Notably, our analysis showed that most of the malignant transformation in the RPA occurred after 30 years of primary tumor removal, in line with other studies indicating a higher risk for malignization in long-standing tumors 13 , 18 , 27 .…”

Section: Discussionsupporting

confidence: 91%

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Lopes-Santos,

Marques,

Tjioe

et al. 2024

Acta Cir. Bras.

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Purpose: This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas. Methods: Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor. Results: Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9–73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval – 95%CI 1.13–27.52), and 20 years (OR = 18.78; 95%CI 3.18–110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up. Conclusions: The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.

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Section: Discussionsupporting

confidence: 91%

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Lopes-Santos,

Marques,

Tjioe

et al. 2024

Acta Cir. Bras.

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“…In a recent systematic review and meta-analysis focusing on the molecular factors involved in the diagnosis of CXPA was conducted by Key and colleagues. 95 This study identified important biomarkers such as p53, PLAG1, and PTEN. 95 Similarly, our results showed CNA in the miR-NAs p53, PLAG1 and PTEN genes.…”

Section: Discussionmentioning

confidence: 96%

“…95 This study identified important biomarkers such as p53, PLAG1, and PTEN. 95 Similarly, our results showed CNA in the miR-NAs p53, PLAG1 and PTEN genes. This may support the role of these genes in the pathogenesis of this pathology and reinforces that these target genes are not only the result of genetic alterations but also of epigenetic alterations.…”

Section: Discussionmentioning

confidence: 96%

“…The KEGG signaling pathway enrichment analysis unveiled a compelling profile of processes governed by the CNA in miRNA genes identified in this study. In a recent systematic review and meta‐analysis focusing on the molecular factors involved in the diagnosis of CXPA was conducted by Key and colleagues 95 . This study identified important biomarkers such as p53, PLAG1, and PTEN 95 .…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

Kimura,

Scarini,

Lavareze

et al. 2024

Head & Neck

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ObjectiveThis study used array comparative genomic hybridization to assess copy number alterations (CNAs) involving miRNA genes in pleomorphic adenoma (PA), recurrent pleomorphic adenoma (RPA), residual PA, and carcinoma ex pleomorphic adenoma (CXPA).Materials and MethodsWe analyzed 13 PA, 4 RPA, 29 CXPA, and 14 residual PA using Nexus Copy Number Discovery software. The miRNAs genes affected by CNAs were evaluated based on their expression patterns and subjected to pathway enrichment analysis.ResultsAcross the groups, we found 216 CNAs affecting 2261 miRNA genes, with 117 in PA, 59 in RPA, 846 in residual PA, and 2555 in CXPA. The chromosome 8 showed higher involvement in altered miRNAs in PAs and CXPA patients. Six miRNA genes were shared among all groups. Additionally, miR‐21, miR‐455‐3p, miR‐140, miR‐320a, miR‐383, miR‐598, and miR‐486 were prominent CNAs found and is implicated in carcinogenesis of several malignant tumors. These miRNAs regulate critical signaling pathways such as aerobic glycolysis, fatty acid biosynthesis, and cancer‐related pathways.ConclusionThis study was the first to explore CNAs in miRNA‐encoding genes in the PA‐CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.

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“…Pleomorphic adenomas (PAs) are the most common benign salivary gland tumors, representing up to 70% of salivary tumors. The malignant transformation of PA is roughly 10% after 15 years ( Key et al, 2022 ). To diagnose a PA or carcinoma ex pleomorphic adenoma (CXPA), a fine-needle aspiration (FNA) must be performed.…”

Section: Case Studymentioning

confidence: 99%

Using Pleomorphic Adenoma Gene 1 (PLAG1) to Distinguish Carcinoma of the Parotid Gland From Primary Lung Cancer: A Case Study

East

2023

JADPRO

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Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma

Cited by 11 publications

References 53 publications

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review

MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma

Using Pleomorphic Adenoma Gene 1 (PLAG1) to Distinguish Carcinoma of the Parotid Gland From Primary Lung Cancer: A Case Study

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