Systematic Review of Psychometric Instruments Used in Research with Psychedelics

Pontual, Alexandre Augusto de Deus; Senhorini, H. G.; Corradi-Webster, Clarissa Mendonça; Tófoli, Luís Fernando; Daldegan‐Bueno, Dimitri

doi:10.1080/02791072.2022.2079108

Cited by 18 publications

(20 citation statements)

References 47 publications

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“…12 A recent review of commonly used psychometric instruments in psychedelic research characterized the MEQ30 based on its representation of the “spiritual or mystical paradigm”. 35 The MEQ directly references spirituality via participant ratings of a ‘sense of being at a spiritual height’ and research has noted that mystical experiences mediate attribution of spiritual significance to the psilocybin session (PEQ). 7,11,12 While the MEQ30 does not explicitly represent concepts of meaning, occurrences of mystical experiences also mediated attribution of personal meaning of the psilocybin session (PEQ).…”

Section: Discussionmentioning

confidence: 99%

An Integrative Review of Measures of Spirituality in Experimental Studies of Psilocybin in Serious Illness Populations

Baker

Ulrich

Meghani

2023

Am J Hosp Palliat Care

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Background: Psilocybin-assisted therapies (PAT) are reemerging as a treatment for complex distress often prompting mystical experiences, enhanced meaning, and spiritual wellbeing. We sought to investigate how measures of spirituality are employed in experimental studies of PAT conducted with seriously ill adults. Methods: We included experimental studies of psilocybin conducted with seriously ill adults, which employed measures that contained spirituality and mysticism concepts within their domains or subdomains. Included studies were peer-reviewed and published in English language (up to December 2021). Results: Seven articles met our inclusion criteria. A total of 12 unique instruments were identified. The most frequently used instruments were the Mystical Experience Questionnaire (MEQ30), the Functional Assessment of Chronic Illness Therapy-Spirituality (FACIT-Sp-12), and the Demoralization Scale (DS-I/II) (used in four studies each), followed by the Persisting Effects Questionnaire (PEQ) (used in three studies). Overall, studies did not consistently define and contextualize spirituality domains and subdomains studied. Conclusions: Despite well-recognized significance of spirituality in PAT, there was considerable heterogeneity in number and types of spirituality measures employed across studies. There also seemed a lack of attention to defining and operationalizing spirituality and its domains and subdomains. This is notable as spirituality and overlapping concepts (eg mystical experiences) contributes substantially to this body of research and patients’ therapeutic outcomes. Towards developing more rigorous science of spirituality in PAT research, there is a critical need to evaluate and refine measures of spirituality to enhance their utility and replicability, limit participant burden, and better contextualize spirituality-related findings and outcomes.

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Section: Discussionmentioning

confidence: 99%

An Integrative Review of Measures of Spirituality in Experimental Studies of Psilocybin in Serious Illness Populations

Baker

Ulrich

Meghani

2023

Am J Hosp Palliat Care

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“…A more detailed description of the questionnaires can be found in Schmidt and Majić [25], Majić et al (2015) [9] and in a recent review by de Deus Pontual et al (2022) [27].…”

Section: Methodsmentioning

confidence: 99%

“…This factor structure is currently recommended for analyses and has been assessed for reliability, yielding good scores for all four subscales (Cronbach's alpha: 0.80 to 0.95) [55,56]. A more detailed description of the questionnaires can be found in Schmidt and Majić [19], Majić et al (2015) [9] and in a recent review by de Deus Pontual et al ( 2022) [21].…”

Section: Questionnairesmentioning

confidence: 99%

“…As LSD has only recently returned to basic and clinical research, only few studies have been carried out according to modern research standards, while the studies from the 1950s to the 1970s exhibit strong methodological limitations and do not appear suited for study overarching comparisons. Over the last decades some gold standards for the assessment of altered states phenomena have been established in terms of several well-validated questionnaires for an retrospective assessment of altered experiences [9,[25][26][27]. Such standardized assessment allows meta-analytic comparisons, as recently presented to establish dose-response relationships for altered experiences induced by psilocybin [26].…”

Section: Introductionmentioning

confidence: 99%

“…In order to determine the optimal dosing ranges of LSD for future clinical studies, first and most importantly the influence of the LSD dose on the nature and intensity of acute subjective effects needs characterization. Over the last decades some gold standards for the assessment of altered states phenomena have been established in terms of several well-validated questionnaires for an retrospective assessment of altered experiences [9,[19][20][21]. Such standardized assessment allows meta-analytic comparisons, as recently presented to establish dose-response relationships for altered experiences induced by psilocybin [20].…”

Section: Introductionmentioning

confidence: 99%

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Dose-response relationships of LSD-induced subjective experiences in humans

Prugger

Hirschfeld

Majić

et al. 2022

Preprint

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Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here we present the first meta-analysis establishing dose-response relationship estimates of the phenomenological states induced by LSD. Data extracted from articles identified by a systematic literature search following PRISMA guidelines were obtained from the Altered States Database. The psychometric data comprised ratings of subjective effects from standardized and validated questionnaires: the Altered States of Consciousness Rating Scale (5D-ASC, 11-ASC) and the Mystical Experience Questionnaire (MEQ30). We used a meta-regression approach to obtain estimates for linear dose-response relationships of questionnaire ratings after LSD administration to healthy, highly selected study participants in controlled settings for a dosage range between 25 μg and 200 μg. LSD doses positively correlated with ratings on most factors and scales of the questionnaires, with strongest responses for visionary phenomena such as audio-visual synesthesia and altered imagery, followed by positively perceived ego dissolution comprising depersonalization and derealization phenomena. Measures referring to mystical experiences exhibited weak modulations by dose. The established dose-response relationships in the given range may be used as general references for future experimental and clinical research on LSD with low to moderate dosages to relate observed with expected subjective effects and to elucidate phenomenological differences between psychedelics.

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Phenomenology of Psychedelic Experiences and Psychedelic-Associated Distressing Effects: Quantifying Subjective Experiences

Costines,

Schmidt

2024

Current Topics in Behavioral Neurosciences

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Systematic Review of Psychometric Instruments Used in Research with Psychedelics

Cited by 18 publications

References 47 publications

An Integrative Review of Measures of Spirituality in Experimental Studies of Psilocybin in Serious Illness Populations

An Integrative Review of Measures of Spirituality in Experimental Studies of Psilocybin in Serious Illness Populations

Dose-response relationships of LSD-induced subjective experiences in humans

Phenomenology of Psychedelic Experiences and Psychedelic-Associated Distressing Effects: Quantifying Subjective Experiences

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