Systematic review of the association between socioeconomic status and bladder cancer survival with hospital type, comorbidities, and treatment delay as mediators

Russell, Beth; Häggström, Christel; Holmberg, Lars; Gårdmark, Truls; Bryan, Richard T.; Kumar, Pardeep; Hemelrijck, Mieke Van

doi:10.1002/bco2.65

Cited by 12 publications

(4 citation statements)

References 72 publications

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“…У хворих на РСМ була показана залежність між соціально-економічним статусом, що виражалось у зменшенні п'ятирічної КСВ, загальної виживаності) та збільшенням ризику канцер-специфічної смертності [95,96]. Аналіз даних GLOBOCAN продемонстрував позитивну кореляцію між валовим внутрішнім продуктом на душу населення та РСМ у чоловіків (r=0,48) та жінок (r=0,44).…”

Section: Cоціально-економічне положенняunclassified

“…Однак наведена залежність не була статистично значущою в мультиваріантному лінійному регресивному аналізі, скоригованому для курців тютюну [97]. Можливими медіаторами впливу соціально-економічного статусу на перебіг РСМ та результати радикальної цистектомії вважаються тип лікарні, де проходить лікування хворий на РСМ, коморбідний стан хворого, а також відтермінування лікування [96].…”

Section: Cоціально-економічне положенняunclassified

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Epidemiology of Bladder Cancer: Current Insight

Golovko

2024

ЗЧ

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Bladder cancer (BC) is a 9th most common cancer in the world that make from 3% of global neoplasms. Bladder cancer is prevalent in the developed countries. Cancer of the bladder is four times more common in men than women. External risk factors and internal triggers contribute to the development of bladder cancer. Thus, comprehensive analysis of these risk factors is a earnest to timely prevention of indicated oncologic pathology. The objective: to do a current systematic review of epidemiology of bladder cancer and modern important risk factors, which appropriate to the given pathology. Evidence acquisition. We carried out a systemic review of epidemiology of bladder cancer embracing PubMed and Embase including March 2023. All studies reporting gender, smoking, E-cigarette use, opium consumption, occupational carcinogene expose, dietary factors, race, gene-environment interaction, socioeconomic status. Microbiome factors, urolithiasis, benign prostate hyperplasiapelvic radiotherapy were excluded. Evidence synthesis. A total of 516 papers, that studied epidemiology of bladder cancer, were involved. According to GLOBOCAN, there were 573 000 new bladder cancer cases and 213 000 deaths worldwide in 2020. Smoking and occupational exposures (aromatic amines and polycyclic aromatic hydrocarbons) are the most important risk factors. Moreover, the additional risk factors include some dietary agents, gene specificities, diesel exhaust emissions and etc. Conclusions. Smoking tobacco and specific occupational exposures are the most important risk factors. Prevention strategies, including smoke cessation, responsible workplace safety, diet, schistosomias prevention are useful for reduction of the incidence BC. But high-quality studies are required to confirm initial results that will support timely prevention of BC.

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Section: Cоціально-економічне положенняunclassified

Epidemiology of Bladder Cancer: Current Insight

Golovko

2024

ЗЧ

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“…SES may influence various aspects of compliance with care, especially given the multi-modal and multi-disciplinary delivery of treatment regimens in MIBC. These include, but are not limited to, shared decision-making, treatment delays, hospital type/resources, insurance accessibility, and financial toxicity [8]. Even after adjusting for such aforementioned social determinants and clinical variables, Washington et al showed that higher income was associated with an increased likelihood of receiving guideline-based, appropriate MIBC treatment [9].…”

Section: Introductionmentioning

confidence: 99%

Income Disparities in Survival and Receipt of Neoadjuvant Chemotherapy and Pelvic Lymph Node Dissection for Muscle-Invasive Bladder Cancer

Antar,

Xu,

Adesanya

et al. 2024

Current Oncology

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Background: Muscle-invasive bladder cancer (MIBC) is a potentially fatal disease, especially in the setting of locally advanced or node-positive disease. Adverse outcomes have also primarily been associated with low-income status, as has been reported in other cancers. While the adoption of neoadjuvant cisplatin-based chemotherapy (NAC) followed by radical cystectomy (RC) and pelvic lymph node dissection (PLND) has improved outcomes, these standard-of-care treatments may be underutilized in lower-income patients. We sought to investigate the economic disparities in NAC and PLND receipt and survival outcomes in MIBC. Methods: Utilizing the National Cancer Database, a retrospective cohort analysis of cT2-4N0-3M0 BCa patients with urothelial histology who underwent RC was conducted. The impact of income level on overall survival (OS) and the likelihood of receiving NAC and PLND was evaluated. Results: A total of 25,823 patients were included. This study found that lower-income patients were less likely to receive NAC and adequate PLND (≥15 LNs). Moreover, lower-income patients exhibited worse OS (Median OS 55.9 months vs. 68.2 months, p < 0.001). Our findings also demonstrated that higher income, treatment at academic facilities, and recent years of diagnosis were associated with an increased likelihood of receiving standard-of-care modalities and improved survival. Conclusions: Even after controlling for clinicodemographic variables, income independently influenced the receipt of standard MIBC treatments and survival. Our findings identify an opportunity to improve the quality of care for lower-income MIBC patients through concerted efforts to regionalize multi-modal urologic oncology care.

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“…Although this is not a traditional review, this type of paper effectively highlights the dilemmas in this space and where future research needs to focus. The review by Russel et al 2 is a traditional systematic review in bladder cancer. They focused on socioeconomic status as a predictor of survival but could also show relationships with modifiable risk factors such as treatment delays.…”

mentioning

confidence: 99%