Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis

Shere, Clare; Clark, Emma

doi:10.1007/s00402-022-04508-z

Cited by 3 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Large studies of an unselected population with both well-defined AIS and well-defined hypermobility are needed to answer this question. Czaprowski et al [ 70 ] Shere and Clark [ 71 ] …”

Section: Discussion/observationsmentioning

confidence: 99%

Pediatric joint hypermobility: a diagnostic framework and narrative review

Tofts

Simmonds

Schwartz

et al. 2023

Orphanet J Rare Dis

View full text Add to dashboard Cite

Background Hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are debilitating conditions. Diagnosis is currently clinical in the absence of biomarkers, and criteria developed for adults are difficult to use in children and biologically immature adolescents. Generalized joint hypermobility (GJH) is a prerequisite for hEDS and generalized HSD. Current literature identifies a large proportion of children as hypermobile using a Beighton score ≥ 4 or 5/9, the cut off for GJH in adults. Other phenotypic features from the 2017 hEDS criteria can arise over time. Finally, many comorbidities described in hEDS/HSD are also seen in the general pediatric and adolescent population. Therefore, pediatric specific criteria are needed. The Paediatric Working Group of the International Consortium on EDS and HSD has developed a pediatric diagnostic framework presented here. The work was informed by a review of the published evidence. Observations The framework has 4 components, GJH, skin and tissue abnormalities, musculoskeletal complications, and core comorbidities. A Beighton score of ≥ 6/9 best identifies children with GJH at 2 standard deviations above average, based on published general population data. Skin and soft tissue changes include soft skin, stretchy skin, atrophic scars, stretch marks, piezogenic papules, and recurrent hernias. Two symptomatic groups were agreed: musculoskeletal and systemic. Emerging comorbid relationships are discussed. The framework generates 8 subgroups, 4 pediatric GJH, and 4 pediatric generalized hypermobility spectrum disorders. hEDS is reserved for biologically mature adolescents who meet the 2017 criteria, which also covers even rarer types of Ehlers–Danlos syndrome at any age. Conclusions This framework allows hypermobile children to be categorized into a group describing their phenotypic and symptomatic presentation. It clarifies the recommendation that comorbidities should be defined using their current internationally accepted frameworks. This provides a foundation for improving clinical care and research quality in this population.

show abstract

“…Large studies of an unselected population with both well-defined AIS and well-defined hypermobility are needed to answer this question. Czaprowski et al [ 70 ] Shere and Clark [ 71 ] …”

Section: Discussion/observationsmentioning

confidence: 99%

Pediatric joint hypermobility: a diagnostic framework and narrative review

Tofts

Simmonds

Schwartz

et al. 2023

Orphanet J Rare Dis

View full text Add to dashboard Cite

show abstract

“…Such insights will contribute to the broader understanding of these conditions and may guide future preventive and therapeutic strategies. 8 …”

mentioning

confidence: 99%

“…Certain elements such as increased height, late onset of puberty, especially delayed menarche in females, and a diminished body mass index have been identified as contributors. [5][6][7][8] Screening strategies encompass Adam's forward bend test, scoliometer measurements of trunk rotation angle, and back surface topography that harnesses digital imagery to detect spinal anomalies. 9 Hypermobility, a condition where the joints can move beyond the typical range, is observed in varying degrees across populations.…”

mentioning

confidence: 99%

Hypermobility Among Adolescents and the Association With Spinal Deformities: A Large Cross-Sectional Study

Hershkovich,

Gordon,

Derazne

et al. 2024

JAAOS Glob Res Rev

View full text Add to dashboard Cite

Introduction: Adolescent idiopathic scoliosis and Scheuermann kyphosis are common spinal deformities (SD) among adolescents. The potential link between hypermobility and SD is a topic of debate. We aimed to investigate the prevalence of hypermobility and its association with SD. Methods: A cross-sectional analysis of records of 17-year-old subjects who were recruited into mandatory military service was conducted. Study population comprised 1,220,073 subjects. Prevalence rates were calculated for hypermobility and different categories of SD by severity, studying the strength of the association between hypermobility and SD. Results: Of 1,220,073 subjects, 0.0111% exhibited hypermobility. Spinal deformities were identified in 10.5% of subjects. Specifically, 7.9% had mild SD, 2.4% had moderate SD, and 0.1% had severe SD. The overall association between hypermobility and SD showed an odds ratio of 2.31 (P < 0.001). Subgroup analyses revealed ORs of 1.226 (P = 0.041) for mild deformities, 5.783 (P < 0.001) for moderate deformities, and 4.01 (P = 0.002) for severe deformities. The association was stronger for moderate and severe SD. Conclusions: This study establishes a notable association between hypermobility and SD among adolescents. The findings highlight the importance of understanding this relationship, which could contribute to advancements in comprehending SD development. Additional research is warranted to expand upon these findings.

show abstract

Myopia and systemic manifestation of tissue hyperlaxity: A population‐based cross‐sectional study

Hecht,

Nitzan,

Safir

2024

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

BackgroundWhether non‐syndromic connective tissue hyperlaxity is associated with myopia is unknown. The aim of this study was to examine the association between systemic signs of tissue hyperlaxity and myopia among adolescents.MethodsIncluded were adolescents assessed before mandatory military service at the age of 16–18 years between 2011 and 2022. Diagnoses of hernias, pes planus, genu varus, genu valgum, and scoliosis, as well as joint injuries were used as surrogate markers for tissue hyperlaxity. The prevalence of these events among adolescents with myopia was evaluated and compared to the non‐myopic population.ResultsIncluded were 920 806 adolescents. The mean age was 17.4 ± 1.4 years and 58.6% were men. Myopia was diagnosed in 290 759 adolescents (31.6%) and high myopia in 24 069 adolescents (2.6%). The prevalence of hernias was higher among adolescents with myopia, (2.76%, 95% confidence interval (95% CI): 2.69%–2.82% vs. 2.60%, 95% CI: 2.57%–2.65%), as were pes planus (14.92%, 95% CI: 14.79–15.05 vs. 13.51%, 95% CI: 13.42–13.59) and scoliosis (9.14%, 95% CI: 9.03–9.24 vs. 7.69%, 95%CI: 7.62–7.76). The prevalence of joint injuries was clinically similar between groups (less than 0.1% difference for ankle, shoulder, and knee injuries), as were genu varum and genu valgum (0.66%, 95%CI: 0.64%–0.69% vs. 0.68%, 95% CI: 0.66–0.70, respectively). Adjusted for possible confounders results remained consistent.ConclusionsAmong a large sample of Israeli adolescents, those with myopia had a higher prevalence of hernias, pes planus, and scoliosis. These results could suggest a propensity for systemic conditions related to tissue laxity among myopic adolescents.

show abstract

Systematic review of the association between isolated musculoskeletal hypermobility and adolescent idiopathic scoliosis

Cited by 3 publications

References 45 publications

Pediatric joint hypermobility: a diagnostic framework and narrative review

Pediatric joint hypermobility: a diagnostic framework and narrative review

Hypermobility Among Adolescents and the Association With Spinal Deformities: A Large Cross-Sectional Study

Myopia and systemic manifestation of tissue hyperlaxity: A population‐based cross‐sectional study

Contact Info

Product

Resources

About