Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss

Chau, Jason; Lin, June R. J.; Atashband, Shahnaz; Irvine, Robert A.; Westerberg, Brian D.

doi:10.1002/lary.20873

Cited by 394 publications

(399 citation statements)

References 33 publications

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“…It is possible to recognise a specific aetiology only in about 10% of cases (Nosrati-Zarenoe et al, 2007;Chau et al, 2010); however, to explain the inner ear damage, several pathogenetic mechanisms were proposed such as vascular, viral, autoimmune, traumatic and metabolic. Impaired cochlear perfusion remains the most supported hypothesis due to the characteristics of inner ear circulation, constituted by a terminal capillary bed without collateral blood supply; vasospasm, thrombosis or vascular haemorrhage may be responsible of a reduced cochlear blood flow with consequent hypoxia, decrease of metabolic activity and damage of cochlear hair cells (Mosnier et al, 2010;Martines et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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Objective: To investigate the relationship between haematological routine parameters and audiogram shapes in patients affected by sudden sensorineural hearing loss (SSNHL). Design: A retrospective study. All patients were divided into four groups according to the audiometric curve and mean values of haematological parameters (haemoglobin, white blood cell, neutrophils and lymphocytes relative count, platelet count, haematocrit, prothrombin time, activated partial thromboplastin time, fibrinogen and neutrophil-to-lymphocite ratio) of each group were statistically compared. The prognostic role of blood profile and coagulation test was also examined. Study sample: A cohort of 183 SSNHL patients without comorbidities. Results: With a 48.78% of complete hearing recovery, individuals affected by upsloping hearing loss presented a better prognosis instead of flat (18.36%), downsloping (19.23%) and anacusis (2.45%) groups (p ¼ 0.0001). The multivariate analysis of complete blood count values revealed lower mean percentage of lymphocytes (p ¼ 0.041) and higher platelet levels (p ¼ 0.015) in case of downsloping hearing loss; with the exception of fibrinogen (p ¼ 0.041), none of the main haematological parameters studied resulted associated with poorer prognosis. Conclusions: Our work suggested a lack of association between haematological parameters and a defined audiometric picture in SSNHL patients; furthermore, only fibrinogen seems to influence the prognosis of this disease.

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Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Salvago

Rizzo

Bianco

et al. 2016

International Journal of Audiology

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“…[2,3] However, the exact incidence of SSHL is higher because a large portion of patients heal spontaneously without medical and surgical treatment [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Different theories have been proposed to explain the etiology. These include, for example, bacterial, viral, and protozoan infections, vascular occlusion, mechanisms associated with the immune system, ototoxicity drugs (salicylates, aminoglycosides) and traumatic, vascular, neoplastic, and metabolic conditions [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume: Is It a Predictive Parameter in The Diagnosis of Sudden Sensorineural Hearing Loss?

Karli

Alaçam

Ünal

et al. 2013

Indian J Otolaryngol Head Neck Surg

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The mean platelet volume (MPV) is associated with increased platelet reactivity and increased atherothrombosis. High MPV values are a risk factor for thrombotic vascular diseases. Our aim was to investigate whether a relationship exists between sudden sensorineural hearing loss (SSHL) and a high MPV value. The records of 46 patients who were admitted to the ENT (ear nose throat) ward for SSHL and received medical treatment and 46 patients in a control group were retrospectively screened. The correlation among the levels of the MPV, the number of platelets, and SSHL were evaluated in the two groups. The ages, genders, and the platelet count values of the patients showed a normal distribution in both groups. No significant difference was found for the MPV values between the groups. The MPV is not a predictive parameter in the diagnosis of SSHL.

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“…A higher blood viscosity may determine damage in ear microcirculation that can produce hearing loss [16,17]. Ciccone et al showed that ISSHL seemed to be associated with vascular endothelial dysfunction and preclinical atherosclerosis by calculating the carotid intima-media thickness [18].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

Yi¹,

Oh²,

Choi³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both < 0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group ( < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL ( = 0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

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Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss

Cited by 394 publications

References 33 publications

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes?

Mean Platelet Volume: Is It a Predictive Parameter in The Diagnosis of Sudden Sensorineural Hearing Loss?

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

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