Systematic review of the incidence of herbal drug-induced liver injury in Korea

Oh, Soo-Jung; Cho, Jung‐Hyo; Son, Chang‐Gue

doi:10.1016/j.jep.2014.11.027

Cited by 31 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, HDS is a significant cause of DI-ALF (16) The increasing use of HDS, especially among patients with chronic liver disease (126,127) , has also been associated with an increase in safety alerts issued by the FDA as well as foreign regulatory bodies for several products (6,77,128) , most recently, weight loss and muscle building compounds (e,g, Herbalife (131), OxyELITE Pro (132) . Significantly higher proportions of patients with DILI are due to HDS from series in Asia where complementary and alternative medicines represents a higher percentage of therapeutic options (83,133,134) (Table 5).…”

Section: Epidemiology Of Dilimentioning

confidence: 99%

The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond

Lewis

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Section: Epidemiology Of Dilimentioning

confidence: 99%

The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond

Lewis

2015

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

“…From the Drug-Induced Liver Injury Network (DILIN) studies, 15.5 % of patients with liver injury were caused by herbal and dietary supplements [5]. In Asian countries, there have been conflicting reports of the number of herbal DILI [6, 7]. However, a subsequent systematic review in reported the incidence of DILI of 0.71 % after exposure to herbal remedies [7].…”

Section: Introductionmentioning

confidence: 99%

“…In Asian countries, there have been conflicting reports of the number of herbal DILI [6, 7]. However, a subsequent systematic review in reported the incidence of DILI of 0.71 % after exposure to herbal remedies [7]. …”

Section: Introductionmentioning

confidence: 99%

“…Additional external cause codes ( T36 – T65 ) are often required after the coding of toxic liver diseases in order to identify the cause of DILI [9, 10]. Toxic liver diseases are mainly contributed by DILI [7]. Since 2002, the Universal Coverage Scheme has been implemented in Thailand for people whose health care cost is neither covered by the Social Health Insurance Scheme nor the Civil Servant Medical Benefit Scheme [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study

et al. 2016

View full text Add to dashboard Cite

BackgroundToxic liver diseases are mainly caused by drug-induced liver injury (DILI). We assessed incidences and outcomes of DILI including associated factors for mortality.MethodsWe performed a population-based study of hospitalized patients with DILI. Information was retrieved from the Nationwide Hospital Admission Data using ICD-10 code of toxic liver diseases (K71) and additional codes (T36–T65). The associated factors were analyzed with log-rank test, univariate and multiple cox regression analysis.ResultsDuring 2009–2013, a total of 159,061 (average 21,165 per year) admissions were related to liver diseases. 6,516 admissions (1,303 per year) were due to toxic liver diseases. The most common type of toxic liver disease was acute hepatitis (33.5 %). In-hospital and 90-day mortality rates were 3.4 % and 17.2 %. DILI with cirrhosis yielded the highest in-hospital and 90-day mortality rates (15.8 % and 47.4 %). Acetaminophen, cirrhosis and age ≥ 60 years were seen in 0.5 %, 8.3 % and 50.1 % of patients who died versus 5 %, 2.3 % and 32.4 % of survivors. Factors associated with mortality were cirrhosis (HR 2.72, 95 % CI: 2.33–3.19), age ≥60 years (HR 2.16, 95 % CI: 1.96–2.38), human immunodeficiency viral infection (HR 2.11, 95 % CI: 1.88–2.36), chronic kidney disease (HR 1.59, 95 % CI: 1.33–1.90), chronic obstructive pulmonary disease and bronchiectasis (HR 1.55, 95 % CI: 1.17–2.04), malnutrition (HR 1.43, 95 % CI: 1.10–1.86) and male (HR 1.31, 95 % CI: 1.21–1.43). Acetaminophen DILI yielded lower risks of mortality (HR 0.24, 95 % CI: 0.13–0.42). The most common causes of DILI were acetaminophen (35.0 %) and anti-tuberculous drugs (34.7 %).ConclusionsDILI is an uncommon indication for hospitalization carrying lower risks of death except in patients with non-acetaminophen, cirrhosis, elderly or concomitant diseases.

show abstract

“…Oh et al analyzed herbal-induced liver injury (HILI) by performing literature review from eight databases, including PubMed, Medline, the Cochrane Library, EMBASE, and four Korean electronic databases. Based on the comprehensive data, the analysis indicated the incidence of hepatotoxicity in patients using herbal drugs and the possibility of increased risk of HILI by coadministration of herbal and conventional medicines [2]. In China, herbal hepatotoxicity and diagnosis of HILI have been reported widely from preclinical studies to clinical observation.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Kim¹,

Kim²,

Go³

et al. 2017

J Int Korean Med

View full text Add to dashboard Cite

In general, herbal medicines have been considered as safe by the general public, since they are naturally occurring and have been applied in treatment for over thousands of years. As the use of herbal medicine is rapidly increasing globally, the potential toxicity of herbal drugs, in particular drug-induced liver injury (DILI), has now become a serious medical issue. According to the literature, the authors analyzed and discussed the hepatotoxicity problem of Chinese herbal medicines (CHM), including global overview on herbal-induced liver injury (HILI), current research progress on toxic CHM, diagnosis and treatment of HILI, and modern approaches and technologies of study of hepatotoxicity. As to promote the recognition of HILI and tackle the issue, a guideline for the diagnosis and treatment of HILI has recently been drafted by Chinese scientists. As suggested by the guideline, the hepatotoxicity issue of CHM, as a matter of fact, is overestimated. Up to date, the investigation of hepatotoxicity of CHM is now booming with worldwide application of CHM. This review therefore provides useful information for investigating hepatotoxicity of herbal medicine and characterizing DILI caused by CHM. In addition, authors describe in which way further efforts should be made to study the rationale of CHM and liver injury.

show abstract

Systematic review of the incidence of herbal drug-induced liver injury in Korea

Cited by 31 publications

References 29 publications

The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond

The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond

The incidence, presentation, outcomes, risk of mortality and economic data of drug-induced liver injury from a national database in Thailand: a population-base study

A Case Report of Liver and Renal Function Changes in Stroke Patients Taking Long-term Herbal Medicine

Contact Info

Product

Resources

About