Systematic review of the literature on the occurrence and characteristics of dyspnea in oncology patients

Shin, Joosun; Kober, Kord M.; Wong, Melisa L.; Yates, Patsy; Miaskowski, Christine

doi:10.1016/j.critrevonc.2022.103870

Cited by 5 publications

(15 citation statements)

References 139 publications

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“…However, these findings need to be interpreted with caution because the results were inconsistent 9,10,18 and sample sizes were relatively small 15,17 . Of note, none of these studies evaluated for risk factors associated with higher levels of distress from shortness of breath 2 …”

Section: Introductionmentioning

confidence: 98%

“…15,17 Of note, none of these studies evaluated for risk factors associated with higher levels of distress from shortness of breath. 2 In terms of associations between shortness of breath and other common symptoms reported by oncology patients, only fourteen studies assessed relationships between its severity and anxiety, 3,4,11,12,14,[19][20][21][22][23][24] depression, 3,4,11,12,[19][20][21][22][23]25 fatigue, 4,19,[24][25][26] pain, 4,11,13,25 and sleep disturbance. 4,19 Most of these analyses were limited to simple correlation coefficients.…”

Section: Introductionmentioning

confidence: 99%

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Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

Shin,

Hammer,

Cooley

et al. 2024

Cancer Medicine

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BackgroundShortness of breath occurs in 10%–70% of oncology patients. Very little is known about interindividual variability in its severity and distress and associated risk factors. Using latent profile analyses (LPAs), purpose was to identify subgroups of patients with distinct severity and distress profiles for shortness of breath as single symptom dimensions. In addition, a joint LPA was done using patients' severity AND distress ratings. For each of the three LPAs, differences among the shortness of breath classes in demographic, clinical, symptom, stress, and resilience characteristics were evaluated.MethodsPatients completed ratings of severity and distress from shortness of breath a total of six times over two cycles of chemotherapy. All of the other measures were completed at enrollment (i.e., prior to the second or third cycle of chemotherapy). Separate LPAs were done using ratings of severity and distress, as well as a joint analysis using severity AND distress ratings. Differences among the latent classes were evaluated using parametric and nonparametric tests.ResultsFor severity, two classes were identified (Slight to Moderate [91.6%] and Moderate to Severe [8.4%]). For distress, two classes were identified (A Little Bit to Somewhat [83.9%] and Somewhat to Quite a Bit [16.1%]). For the joint LPA, two classes were identified (Lower Severity and Distress [79.9%] and Higher Severity and Distress [20.1%]). While distinct risk factors were associated with each of the LPAs, across the three LPAs, the common risk factors associated with membership in the worse class included: a past or current history of smoking, poorer functional status, and higher comorbidity burden. In addition, these patients had a higher symptom burden and higher levels of cancer‐specific stress.ConclusionsClinicians can use the information provided in this study to identify high‐risk patients and develop individualized interventions.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

Shin,

Hammer,

Cooley

et al. 2024

Cancer Medicine

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“…Dyspnea or breathlessness is a common, debilitating symptom among cancer survivors, especially in those with advanced cancers [ 1 , 2 ]. Dyspnea is defined as “subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity” [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dyspnea is defined as “subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity” [ 3 ]. Other terms such as “shortness of breath”, “difficulty breathing”, “chest tightness” and “air hunger” are also frequently used in the literature [ 1 , 3 ]. The prevalence of dyspnea is ranging from 10% to 70% of patients with cancer according to systematic review of over 10,000 patients [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of dyspnea is ranging from 10% to 70% of patients with cancer according to systematic review of over 10,000 patients [ 4 ]. A recent systematic review reported an average dyspnea prevalence of 58% (range 10% to 90%) among patients with advanced all-type cancers, and 34.9% among patients with lung cancer, respectively [ 1 ]. In particular, 45.5% of cancer survivors experienced exertional dyspnea, a factor that negatively affects activities of daily living and exercise [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential Therapeutic Role of Respiratory Muscle Training in Dyspnea Management of Cancer Survivors: A Narrative Review

Vainshelboim,

Sardesai,

Bhammar

2024

World J Oncol

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Dyspnea is a disabling symptom presented in approximately half of all cancer survivors. From a clinical perspective, despite the availability of pharmacotherapies, evidence-based effective treatments are limited for relieving dyspnea in cancer survivors. Preliminary evidence supports the potential of respiratory muscle training to reduce dyspnea in cancer survivors, although large randomized controlled studies are warranted. The aims of this article were to review the relevant scientific literature on the potential therapeutic role of respiratory muscle training in dyspnea management of cancer survivor, and to identify possible mechanisms, strengths and limitations of the evidence as well as important gaps for future research directions.

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Ninjin’yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study

Mitsui,

Tanaka,

Nishikubo

et al. 2024

Surg Today

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Purpose This study evaluated the efficacy of ninjin’yoeito for alleviating postoperative symptoms after lung cancer surgery. Methods Overall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin’yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function. Results The mean change in the CFS score 8 weeks postoperatively was − 5.56 in the ninjin’yoeito group and − 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were − 5.60 and − 3.38 in the ninjin’yoeito and conventional groups, respectively, with a difference of − 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were − 340.5 mL in the ninjin’yoeito group and − 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin’yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040). Conclusion The results of this study show that ninjin’yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.

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Systematic review of the literature on the occurrence and characteristics of dyspnea in oncology patients

Cited by 5 publications

References 139 publications

Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

Potential Therapeutic Role of Respiratory Muscle Training in Dyspnea Management of Cancer Survivors: A Narrative Review

Ninjin’yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study

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