Study Design
Cost Effectiveness Analysis
Objective
To examine the cost-effectiveness of operative vs. non-operative treatment of type-II odontoid fractures in patients over 64 years old.
Summary of Background Data
Significant controversy exists regarding the optimum treatment of geriatric patients with type-II odontoid fractures. Operative treatment leads to lower rates of non-union but carries surgical risks. Non-operative treatment does not carry surgical risks but has higher non-union rates.
Methods
A decision-analytic model was created to compare operative and non-operative treatment of type-II odontoid fractures among three age cohorts (65–74, 75–84, over-84) based on expected costs, quality-adjusted life years (QALYs) and incremental cost-effectiveness ratios (cost per QALY gained). Age-specific mortality rates for both treatments, costs for treatment, and complication rates were taken from the literature, and data from 2010 US life tables was used for age-specific life expectancy. Costs of complications were estimated using data obtained at a Level-I trauma center using micro-costing. Sensitivity analyses of all model parameters were conducted.
Results
Among the 65–74 year old cohort, operative treatment was more costly ($53,407 vs. $30,553) and more effective (12.00 vs. 10.11 QALY), with an incremental cost effectiveness ratio (ICER) of $12,078/QALY. Among the 75–84 year old cohort, operative treatment was more costly ($51,308 vs. $29,789) and more effective (6.85 vs. 6.31 QALY), with an ICER of $40,467/QALY. Among the over-84 cohort, operative treatment was dominated by non-operative treatment as it was both more costly ($45,978 vs. $28,872) and less effective (2.48 vs 3.73 QALY). The model was robust to sensitivity analysis across reasonable ranges for utility of union, disutility of complications and delayed surgery, and probabilities of non-union and complications.
Conclusions
Operative treatment is cost-effective in patients age 65–84 when using $100,000/QALY as a benchmark but less effective and more costly than non-operative treatment in patients over age 84 years.