Systematic review: prevention of travellers’ diarrhoea

DuPont, Herbert L.

doi:10.1111/j.1365-2036.2008.03647.x

Cited by 49 publications

(34 citation statements)

References 102 publications

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“…If available, we used data after a followup period of 1 year, or as close to this time point as possible. Studies involving patients with traveller's diarrhoea were excluded because it has been suggested that these are predominantly caused by enterotoxigenic E. coli, which has a milder course and a lower risk of developing PI-IBS [17].…”

Section: Literature Reviewmentioning

confidence: 99%

Disease burden of post-infectious irritable bowel syndrome in The Netherlands

et al. 2010

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SUMMARYPost-infectious irritable bowel syndrome (PI-IBS) has been established as a sequel of infectious intestinal disease (IID). The aim of this study was to estimate the burden of PI-IBS caused by the pathogens Campylobacter, Salmonella and Shigella, and to compare this with other outcomes associated with these pathogens. The attributable risk of PI-IBS due to bacterial pathogens was calculated and linked to national data on gastroenteritis incidence and measures for severity and duration of illness in order to estimate the burden of PI-IBS. One year post-infection, IBS developed in 9 % of patients with bacterial IID. The burden of PI-IBS adds over 2300 disability adjusted life years to the total annual disease burden for the selected pathogens. PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID.

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Section: Literature Reviewmentioning

confidence: 99%

Disease burden of post-infectious irritable bowel syndrome in The Netherlands

et al. 2010

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“…Esto fue obtenido a partir de revisiones del tema que dividen a los países en tres categorías (según su nivel de desarrollo y condiciones de salubridad) 18 , clasificándolo como zona de bajo riesgo (ZBR: Países de Europa occidental, E.U.A., Canadá, Australia, Japón y Nueva Zelandia) o de alto riesgo (ZAR: Países de África, Latinoamérica y el sur de Asia). No se tomaron en cuenta las personas que residían en zonas de riesgo intermedio, por ser muy pocas (n: 94; 6,0%) y por no ser zonas de residencia que habitualmente tienen los turistas que visitan el Perú.…”

Section: Variablesunclassified

“…Además, los residentes de estos países tienen mejores medidas higiénico-preventivas 18 , así como la costumbre de buscar consejería médica y, en general, mejores medidas para el cuidado de su salud.…”

Section: Artículo Originalunclassified

Características asociadas a la consulta pre viaje en turistas que visitan Cusco, Perú

Mejía

Cvetkovic‐Vega

Cruz

et al. 2016

Rev. chil. infectol.

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“…ETEC is the chief cause of diarrhoeal morbidity and infant mortality in developing countries, and it is also perennially associated with diseases like traveller's diarrhoea in developing countries (DuPont, 2008). Therefore, a safe and effective vaccine against ETEC is essential for public health (Daley et al, 2007;Gaastra & Svennerholm, 1996).…”

Section: Introductionmentioning

confidence: 99%

Construction of Bifidobacterium infantis as a live oral vaccine that expresses antigens of the major fimbrial subunit (CfaB) and the B subunit of heat-labile enterotoxin (LTB) from enterotoxigenic Escherichia coli

Luo

Xue-ping

et al. 2012

Microbiology

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We sought to develop Bifidobacterium infantis (BI) as a vehicle for the expression of heterologous antigens. Two proteins of enterotoxigenic Escherichia coli (ETEC) were expressed in BI: CfaB, a major fimbrial subunit protein, and LTB, the B subunit of heat-labile enterotoxin. The expression of CfaB and LTB in BI was verified by electrophoretic analysis. Sprague-Dawley rats were then subjected to intragastric immunization with BI-CfaB and BI-LTB systems both separately and together. ELISA was used to characterize the serum and mucosal immune responses against ETEC antigens. The immunized rats were intraperitoneally challenged with wild-type ETEC H10407 to study the immune response in vivo. The serum titres of IgG and faecal IgA antibodies in the BI-CfaB plus BI-LTB mixed vaccination group were significantly greater than those in the other two groups, which were immunized with a single vaccine (P,0.05). However, no significant difference was seen between the two groups that received a single immunization. These results suggest that expressing CfaB and LTB in BI provides a probiotic system with immunogenic properties. Furthermore, the expression of LTB in BI preserved its mucosal adjuvant effect. So this study confirms that BI can be used as a novel oral vaccine expression system for a heterologous antigen and BI-LTB can provide mucosal adjuvant properties.

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Systematic review: prevention of travellers’ diarrhoea

Cited by 49 publications

References 102 publications

Disease burden of post-infectious irritable bowel syndrome in The Netherlands

Disease burden of post-infectious irritable bowel syndrome in The Netherlands

Características asociadas a la consulta pre viaje en turistas que visitan Cusco, Perú

Construction of Bifidobacterium infantis as a live oral vaccine that expresses antigens of the major fimbrial subunit (CfaB) and the B subunit of heat-labile enterotoxin (LTB) from enterotoxigenic Escherichia coli

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