Systematic review: probiotics for functional constipation in children

Wojtyniak, Katarzyna; Szajewska, Hania

doi:10.1007/s00431-017-2972-2

Cited by 87 publications

(69 citation statements)

References 30 publications

(68 reference statements)

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“…Beyond the antipathogenic properties of Lcr35 ® , recent studies in humans have shown improvement in the health of patients with the administration of LBM. The effectiveness of Lcr35 ® for the treatment of abdominal pain and intestinal functional disorders has been demonstrated in children [22][23][24] without however highlighting the molecular mechanisms. Recently, Dausset and colleagues demonstrated in women the safety and well-tolerated characteristics of a new galenic form based on Lcr35 ® , promoting the growth of endogenous vaginal Lactobacillus, in order to prevent an eventual dysbiosis [25].…”

Section: Discussionmentioning

confidence: 99%

Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights

et al. 2019

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The resistance of Candida albicans to conventional drug treatments, as well as the recurrence phenomena due to dysbiosis caused by antifungal treatments, have highlighted the need to implement new therapeutic methodologies. The antifungal potential of live biotherapeutic products (LBP) has already been demonstrated using preclinical models (cell cultures, laboratory animals). Understanding their mechanisms of action is strategic for the development of new therapeutics for humans. In this study, we investigated the curative anti-C. albicans properties of Lactobacillus rhamnosus Lcr35 ® using the in vitro Caco-2 cell and the in vivo Caenorhabditis elegans models. We showed that Lcr35 ® does inhibit neither the growth (p = 0.603) nor the biofilm formation (p = 0.869) of C. albicans in vitro. Lcr35 ® protects the animal from the fungal infection (+225% of survival, p < 2 × 10 -16 ) even if the yeast is detectable in its intestine. In contrast, the Lcr35 ® cell-free supernatant does not appear to have any antipathogenic effect. At the mechanistic level, the DAF-16/Forkhead Box O transcription factor is activated by Lcr35 ® and genes of the p38 MAP Kinase signaling pathway and genes involved in the antifungal response are upregulated in presence of Lcr35 ® after C. albicans infection. These results suggest that the LBM strain acts by stimulating its host via DAF-16 and the p38 MAPK pathway.

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Section: Discussionmentioning

confidence: 99%

Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights

et al. 2019

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“…A recent systematic review included seven RCTs enrolling a total of 515 children that investigated the effects of probiotics in pediatric FC. Although two of the included studies, those evaluating L. reuteri DSM 17938 165 and B. longum 166 , reported significantly increased defecation frequency in the treatment arm, the meta-analysis concluded that there is currently insufficient evidence to support the use of probiotics for pediatric FC 167 . Finally, although a low-fiber diet is a known risk factor for FC in children 168 , there is currently little evidence to support the use of fiber for pediatric FC.…”

Section: Functional Gi Disordersmentioning

confidence: 97%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

133

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The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota-host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain-gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

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“…In the literature, five systematic review articles were found, 30,[33][34][35][36] Two had a meta-analysis, 30,34 which addressed the use of probiotics in the treatment of functional constipation in children and adolescents. An article published in 2010 33 included two clinical trials in children 18,21 and three adult trials, and concluded that only L. rhamnosus Lcr35 showed a beneficial effect for the treatment of constipation in children.…”

Section: Lactobacillus Casei Rhamnosus Lcr35mentioning

confidence: 99%

“…A systematic review published in 2016 35 on the use of prebiotics, probiotics and symbiotics for the treatment of functional constipation in children concluded that there is still insufficient evidence to support the recommendation of probiotics in this treatment. At the same time as the present article was being completed, two systematic reviews were published 30,36 addressing this theme. In 2017, a systematic meta-analysis review highlighted the effectiveness of probiotics for improving bowel movement frequency in Asian children, and highlighted the heterogeneity of the studies.…”

Section: Lactobacillus Casei Rhamnosus Lcr35mentioning

confidence: 99%

“…16,[18][19][20][21][22][23] It was noted that some probiotic strains had some effects on the frequency of bowel movements, but no effects on the frequency of fecal incontinence and abdominal pain. 36 Given the heterogeneity of clinical trials conducted with children and adolescents, there is a need to standardize the criteria and definitions used to compare the effects of different therapeutic interventions, as mentioned in the literature. 37,38 Therefore, regardless of the analyzes performed, there is not enough evidence to support the recommendation of probiotics for the treatment of constipation in children and adolescents.…”

Section: Lactobacillus Casei Rhamnosus Lcr35mentioning

confidence: 99%

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Gut Microbiota and the Use of Probiotics in Constipation in Children and Adolescents: Systematic Review

Gomes

Morais

2020

Rev. paul. pediatr.

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Objective: To perform a systematic review of literature data on gut microbiota and the efficacy of probiotics for the treatment of constipation in children and adolescents. Data source: The research was performed in the PubMed, the Scientific Electronic Library Online (SciELO) and the Latin American and Caribbean Health Sciences Literature (LILACS) databases in English, Portuguese and Spanish. All original articles that mentioned the evaluation of the gut microbiota or the use of probiotics in children with constipation in their title and abstract were selected. Data synthesis: 559 articles were found, 47 of which were selected for reading. From these, 12 articles were included; they studied children and adolescents divided into two categories: a gut microbiota evaluation (n=4) and an evaluation of the use of probiotics in constipation therapy (n=8). The four papers that analyzed fecal microbiota used different laboratory methodologies. No typical pattern of gut microbiota was found. Regarding treatment, eight clinical trials with heterogeneous methodologies were found. Fifteen strains of probiotics were evaluated and only one was analyzed in more than one article. Irregular beneficial effects of probiotics have been demonstrated in some manifestations of constipation (bowel frequency or consistency of stool or abdominal pain or pain during a bowel movement or flatulence). In one clinical trial, a complete control of constipation without the use of laxatives was obtained. Conclusions: There is no specific pattern of fecal microbiota abnormalities in constipation. Despite the probiotics’ positive effects on certain characteristics of the intestinal habitat, there is still no evidence to recommend it in the treatment of constipation in pediatrics.

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Systematic review: probiotics for functional constipation in children

Cited by 87 publications

References 30 publications

Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights

Curative Treatment of Candidiasis by the Live Biotherapeutic Microorganism Lactobacillus rhamnosus Lcr35® in the Invertebrate Model Caenorhabditis elegans: First Mechanistic Insights

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Gut Microbiota and the Use of Probiotics in Constipation in Children and Adolescents: Systematic Review

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