Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors

Hunfeld, Nicole; Geus, W. P.; Kuipers, Ernst J.

doi:10.1111/j.1365-2036.2006.03171.x

Cited by 57 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a similar result was not found in three different studies that examined patients who suddenly stopped PPI therapy while using it for GERD. Contrary to Lodrup's systematic literature review, Hunfeld reported in his systematic literature review that no significant rebound acid secretion occurred with the sudden cessation of PPIs in healthy volunteers (28).…”

Section: How Must the Drugs Used In The Treatment Of Gerd Be Stopped?mentioning

confidence: 91%

Medical treatment of gastroesophageal reflux disease

Bor

Kalkan

2017

Turk J Gastroenterol

View full text Add to dashboard Cite

Section: How Must the Drugs Used In The Treatment Of Gerd Be Stopped?mentioning

confidence: 91%

Medical treatment of gastroesophageal reflux disease

Bor

Kalkan

2017

Turk J Gastroenterol

View full text Add to dashboard Cite

“…This along with the finding of non-inferiority at day 90 for Succeed® compared with omeprazole raises the question of whether omeprazole continues to result in acid suppression over a prolonged period of time. However, there is very limited strong evidence of rebound acid hypersecretion in humans following cessation of treatment with proton pump inhibitors for periods of longer than eight weeks [32].…”

Section: Discussionmentioning

confidence: 99%

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

Kerbyson

Knottenbelt

Carslake

et al. 2016

Journal of Equine Veterinary Science

View full text Add to dashboard Cite

Although several studies have assessed the short-term effect of dietary supplements on the treatment and prevention of gastric ulceration in horses, few have assessed the response over a duration of more than 30 days. 2A blinded randomised non-inferiority clinical trial was conducted using forty-two Thoroughbred horses in race training with squamous ulceration of ≥ grade 2/4, randomly assigned to one of two treatment groups for a period of 90 days: omeprazole at the full label dose of 4mg/kg or the Succeed® digestive conditioning supplement. Non-inferiority analyses and Wilcoxon sign rank tests were used to analyse the data.At day 90, Succeed® was non-inferior to 4mg/kg omeprazole administered daily in terms of the proportion of horses with complete resolution of squamous ulceration.At day 30, Succeed® was found to be inferior to omeprazole in terms of the proportion of horses with grade ≤1/4 squamous ulceration. The proportion of horses with reducing squamous ulcer score (compared with day 0) was statistically significant for both treatments at days 30 and 60. At day 90 of the 17 horses on Succeed®, nine had a reducing squamous ulcer score (p-value = 0.049) and of the 19 horses on omeprazole, 10 had a reducing squamous ulcer score at day 90 (p-value = 0.091).The non-inferiority of Succeed® compared to omeprazole at 90 days for the complete resolution of squamous ulceration and the reduced efficacy of omeprazole following 90 days of treatment are likely to be of interest to practitioners managing gastric ulceration in performance horses.

show abstract

“…Rebound acid hypersecretion due to the PPI break is possible, but most likely not important within the 4-day break used. 58,59 We believe that blinding of subjects to the test liquid used should assure unbiased results in terms of, eg, swallowing rate and heartburn. As a result of our chosen protocol, the random swallowing test was only performed in the upright position.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett‘s Esophagus Than in Healthy Controls

Lottrup

Krarup

Gregersen

et al. 2016

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsImpaired esophageal acid clearance may be a contributing factor in the pathogenesis of Barrett's esophagus. However, few studies have measured acid clearance as such in these patients. In this explorative, cross-sectional study, we aimed to compare esophageal acid clearance and swallowing rate in patients with Barrett's esophagus to that in healthy controls. MethodsA total of 26 patients with histology-confirmed Barrett's esophagus and 12 healthy controls underwent (1) upper endoscopy, (2) an acid clearance test using a pH-impedance probe under controlled conditions including controlled and random swallowing, and (3) an ambulatory pH-impedance measurement. ResultsCompared with controls and when swallowing randomly, patients cleared acid 46% faster (P = 0.008). Furthermore, patients swallowed 60% more frequently (mean swallows/minute: 1.90 ± 0.74 vs 1.19 ± 0.58; P = 0.005), and acid clearance time decreased with greater random swallowing rate (P < 0.001). Swallowing rate increased with lower distal esophageal baseline impedance (P = 0.014). Ambulatory acid exposure was greater in patients (P = 0.033), but clearance times assessed from the ambulatory pHmeasurement and acid clearance test were not correlated (all P > 0.3). ConclusionsMore frequent swallowing and thus faster acid clearance in Barrett's esophagus may constitute a protective reflex due to impaired mucosal integrity and possibly acid hypersensitivity. Despite these reinforced mechanisms, acid clearance ability seems to be overthrown by repeated, retrograde acid reflux, thus resulting in increased esophageal acid exposure and consequently mucosal changes.

show abstract

Systematic review: rebound acid hypersecretion after therapy with proton pump inhibitors

Abstract: SUMMARY BackgroundThe occurrence and the clinical relevance of rebound acid hypersecretion after discontinuation of proton pump inhibitors is unclear.

Cited by 57 publications

References 29 publications

Medical treatment of gastroesophageal reflux disease

Medical treatment of gastroesophageal reflux disease

A Comparison Between Omeprazole and a Dietary Supplement for the Management of Squamous Gastric Ulceration in Horses

Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett‘s Esophagus Than in Healthy Controls

Contact Info

Product

Resources

About