2018
DOI: 10.1016/j.jemermed.2018.04.025
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Systematic Review: Rectal Administration of Medications for Pediatric Procedural Sedation

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Cited by 12 publications
(22 citation statements)
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“…As the rectal mucosa is highly vascularised, this route of administration is useful for rapid systemic drug absorption, particularly in an emergency or when the oral route is unavailable. Rectal formulations have been used in pain management [ 102 , 103 ], sedation [ 104 ] and treatment of seizures [ 105 ]. Compared to other transmucosal routes of administration, one of the distinct advantages of rectal delivery is that it is not limited by vomiting which patients commonly experience as they approach the ends of their lives.…”
Section: Rectal Deliverymentioning
confidence: 99%
“…As the rectal mucosa is highly vascularised, this route of administration is useful for rapid systemic drug absorption, particularly in an emergency or when the oral route is unavailable. Rectal formulations have been used in pain management [ 102 , 103 ], sedation [ 104 ] and treatment of seizures [ 105 ]. Compared to other transmucosal routes of administration, one of the distinct advantages of rectal delivery is that it is not limited by vomiting which patients commonly experience as they approach the ends of their lives.…”
Section: Rectal Deliverymentioning
confidence: 99%
“…The rectal (transmucosal) route is particularly convenient for PPS, especially for infants, because it is not invasive, does not pose any choking risks, and does not need to be taste-masked [ 8 ]. It also has the advantage of a rapid and more predictable onset than the oral route [ 9 ]. Rectally administered drugs, which are described in the literature as being possible to use for PPS, are benzodiazepines, chloral hydrate, ketamine, and barbiturates; however, according to Lam et al [ 9 ] in their 2018 systemic review, rectal midazolam (the main benzodiazepine used for PPS) was the least effective of these drugs, and ketamine induced very common adverse effects (hypersalivations and hallucinations, for example).…”
Section: Introductionmentioning
confidence: 99%
“…It also has the advantage of a rapid and more predictable onset than the oral route [ 9 ]. Rectally administered drugs, which are described in the literature as being possible to use for PPS, are benzodiazepines, chloral hydrate, ketamine, and barbiturates; however, according to Lam et al [ 9 ] in their 2018 systemic review, rectal midazolam (the main benzodiazepine used for PPS) was the least effective of these drugs, and ketamine induced very common adverse effects (hypersalivations and hallucinations, for example). They reported a sedating efficacy of 60–75% for midazolam in most trials versus 80–95% for the other drugs.…”
Section: Introductionmentioning
confidence: 99%
“…Chemical immobilization can be required for blood sampling, X-rays, biopsy, or other procedures [ 1 ]. The intrarectal route (IR) is widely used in human medicine for the sedation of uncooperative patients, such as children, and has wide safety margins [ 3 ]. Common routes of sedation in cats are intramuscular (IM), intravenous (IV), and oral (OS).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, IR administration can provide significant local and systemic levels for various drugs, despite the relatively small surface area of the rectal mucosa [ 6 , 7 ]. In human medicine, IR administration is used for the treatment of epileptic seizures [ 3 , 6 ], during pediatric sedation, for burn wounds [ 8 ], for vomiting, and for dysphagia patients [ 9 ]. In veterinary medicine, IR administration is extensively investigated for the control of epileptic seizures in dogs, but less so in cats [ 10 , 11 ].…”
Section: Introductionmentioning
confidence: 99%