Systematic Review: The Role of Breastfeeding in the Development of Pediatric Inflammatory Bowel Disease

Breastfeeding policy: a globally comparative analysis

“…Studies around the world in affluent and poor nations alike have shown a 1.5-to five-fold decrease in mortality among breastfed infants. [7][8][9][10] Breastfeeding has also been associated with lower rates of chronic diseases such as diabetes 11,12 and inflammatory bowel disease 13,14 and with improved neurocognitive development. [15][16][17][18] Breastfeeding is beneficial to the health of both women and infants.…”

Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression

“…There is a major gap in our knowledge of whether the beneficial effects of breast milk-derived SIgA persist after weaning. Epidemiological studies suggest that early exposure to breast milk reduces the risk of developing inflammatory bowel disease (IBD) in children (7). However, the fact that breast milk contains many bioactive molecules (8,9) makes it difficult to ascertain the specific effects of SIgA.…”

Management of inflammatory bowel disease in pregnancy

“…Moffatt et al found in a Canadian population-based study that breastfeeding was associated with a nonsignificant decrease in flares, suggesting that breastfeeding may actually be protective against flares in the postpartum period [59]. Additionally, while some earlier studies have suggested no reduced risk of IBD with breastfeeding [60,61], Barclay et al concluded in their 2009 systematic review that breastfeeding among non-IBD women exerted a protective effect (OR: 0.69; 95% CI: 0.51-0.94) against developing early-onset IBD [62].…”