Systematic review with meta‐analysis: magnetic resonance enterography vs. computed tomography enterography for evaluating disease activity in small bowel Crohn's disease

Qiu, Yun; Mao, Ren; Chen, B.-L.; Li, X.-H.; He, Yao; Zeng, Zhi; Li, Z.-P.; Chen, M.-H.

doi:10.1111/apt.12815

Cited by 122 publications

(87 citation statements)

References 37 publications

(69 reference statements)

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“…However, MRE was superior to CTE in detecting strictures (p = 0.04) and ileal wall enhancement (p = 0.02). A 2014 meta-analysis by Qiu et al [44] of 290 CD patients across six studies, found no significant difference between the diagnostic accuracy of MRE and CTE in detecting active small bowel CD and its complications including fistula, stenosis and abscess formation. Given its proven diagnostic accuracy, updated guidelines by the European Crohn's and Colitis Organisation and the European Society of Gastrointestinal and Abdominal Radiology, advocate increased routine usage of MRI for the assessment of small bowel CD, to reduce radiation exposure in this cohort of patients [45] .…”

Section: Mrementioning

confidence: 99%

Diagnostic imaging and radiation exposure in inflammatory bowel disease

Zakeri¹,

Pollok²

2016

WJG

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Section: Mrementioning

confidence: 99%

Diagnostic imaging and radiation exposure in inflammatory bowel disease

Zakeri¹,

Pollok²

2016

WJG

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“…The exposure to ionizing radiation with CTE, however, constrains its application for the repeated assessment of disease activity and MH. 65,66 Initial studies investigating the value of MRE in monitoring disease activity and treatment response showed inconsistent results. Some investigators demonstrated a significant correlation between MRE signal intensity and treatment response, 67 whereas others found that, although significant improvements in MRE findings occurred, normalization of findings with treatment was rare despite meaningful changes in clinical disease activity.…”

Section: Magnetic Resonance Enterographymentioning

confidence: 99%

“…70 Given the enhanced sensitivity over other small-bowel imaging techniques (Table 4), 65,71,72 consideration has been given to using VCE as the first or second line diagnostic test for the assessment of MH. An initial prospective study of 40 patients with known or suspected nonstricturing, nonpenetrating CD investigated the use of VCE for assessment of MH during an acute CD flare.…”

Section: Video Capsule Endoscopymentioning

confidence: 99%

Assessment of mucosal healing in inflammatory bowel disease: review

Dulai¹,

Levesque²,

Feagan³

et al. 2015

Gastrointestinal Endoscopy

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“…In addition to endoscopy, ultrasonography, CT and MRI are widely used for evaluation of gut inflammation in IBD [11,12,28,29] . These 3 techniques have a high comparable diagnostic accuracy for the detection of lesions in IBD.…”

Section: Introductionmentioning

confidence: 99%

Molecular Endoscopy and in vivo Imaging in Inflammatory Bowel Diseases

Neurath

2015

Dig Dis

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Background: Studies in recent years have shown that standard imaging modalities such as endoscopy, ultrasonography or MRI are essential for assessment of gut inflammation in patients with inflammatory bowel diseases (IBDs). In addition, endoscopy plays a pivotal role in the analysis of mucosal healing in these disorders. However, these techniques do not allow a detailed analysis of the molecular pathways driving gut inflammation in IBD patients. Here, we discuss the role of new techniques for the molecular imaging of gut inflammation in IBD with special reference to the prediction of responses to therapy using antibodies to tumor necrosis factor (anti-TNF). Key Messages: Several in vivo imaging studies have been performed in IBD patients before and after anti-TNF therapy. In one study, (99m)Technetium-labeled annexin V was given to patients with active Crohn's disease before and after anti-TNF therapy with infliximab. Subsequently, single-photon emission CT (SPECT) was performed to study the effect of anti-TNF treatment on apoptosis in the intestine during active colitis. This study showed enrichment of technetium signals in the gut of patients who responded to anti-TNF therapy. The findings suggested that anti-TNF treatment induces T-cell apoptosis in vivo and that SPECT imaging can be used for prediction of response to anti-TNF therapy. In another study, fluorescent anti-TNF antibodies (fluorescent adalimumab) were chosen for molecular imaging during confocal laser endomicroscopy in patients with active Crohn's disease. This study revealed that an increase of membrane-bound TNF expressing mucosal immune cells predicts response to subsequent adalimumab therapy. Conclusions: Molecular in vivo imaging is an exciting new field in patients with IBD. It is expected that this field will allow new insights into the pathophysiology of IBD and may be used for personalized medicine in the future.

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Systematic review with meta‐analysis: magnetic resonance enterography vs. computed tomography enterography for evaluating disease activity in small bowel Crohn's disease

Abstract: Summary BackgroundMagnetic resonance enterography (MRE) has been proposed as a non-ionising alternative method to computed tomography enterography (CTE). Some studies have directly compared CTE and MRE in patients with small bowel Crohn's disease (CD) with variable results.

Cited by 122 publications

References 37 publications

Diagnostic imaging and radiation exposure in inflammatory bowel disease

Diagnostic imaging and radiation exposure in inflammatory bowel disease

Assessment of mucosal healing in inflammatory bowel disease: review

Molecular Endoscopy and in vivo Imaging in Inflammatory Bowel Diseases

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