Systematic Reviews in Health Care 2001
DOI: 10.1002/9780470693926.ch12
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Systematic Reviews of Observational Studies

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Cited by 148 publications
(104 citation statements)
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“…[2] However, meta-analyses of observational studies cannot adequately incorporate the effects of confounding factors. [16] We found that age, wheezing phenotype, and differential exposure to risk factors need to be taken into consideration when interpreting crude 13 prevalence figures. Family history of atopy, maternal smoking, keeping pets, short duration of breastfeeding and family history of wheeze were all more common in whites, while socio-economic conditions also had an additional important confounding effect.…”
Section: Comparison With Other Studiesmentioning
confidence: 89%
“…[2] However, meta-analyses of observational studies cannot adequately incorporate the effects of confounding factors. [16] We found that age, wheezing phenotype, and differential exposure to risk factors need to be taken into consideration when interpreting crude 13 prevalence figures. Family history of atopy, maternal smoking, keeping pets, short duration of breastfeeding and family history of wheeze were all more common in whites, while socio-economic conditions also had an additional important confounding effect.…”
Section: Comparison With Other Studiesmentioning
confidence: 89%
“…25 Epidemiological studies are prone to publication bias as only statistically significant findings may be published. 26 Other problems which are likely to be greater in meta-analyses of retrospective, nonrandomised studies include inadequate reporting of methods, variation in study design, variation in inclusion criteria and variation in presentation of results.…”
Section: Discussionmentioning
confidence: 99%
“…Some compare children who had NEC with those born ELBW who did not have NEC, others compare the outcomes of babies treated conservatively with those receiving surgery. Metaanalyses can be usefully performed on non-randomised studies, 25 in which case caveats must be drawn in the interpretation of the results. Clearly, in comparing ELBW infants who had NEC with those that did not get NEC, we are comparing two populations rather than two groups of individuals randomly allocated from the same population.…”
Section: Discussionmentioning
confidence: 99%
“…41 The Guideline Recommendation and Evidence Grading (GREG) scheme 42 (see Chapter 3, Box 1) was used to summarise the quality of evidence and also of subsequent recommendations.…”
Section: Figure 1 Flow Chart Of All Literature Reviewedmentioning
confidence: 99%