Systematic study of (MoTa) NbTiZr medium- and high-entropy alloys for biomedical implants- In vivo biocompatibility examination

Akmal, Muhammad; Hussain, Ahtesham; Afzal, Muhammad; Lee, Young Ik; Ryu, Ho Jin

doi:10.1016/j.jmst.2020.10.049

Cited by 66 publications

(23 citation statements)

References 34 publications

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“…Animal models are an effective approach to evaluate the service status of materials in the in vivo environment. Akmal ( Akmal et al, 2021 ) demonstrated (MoTa) x NbTiZr implantation inside a mouse thigh and counted the changes in the mouse thigh over 16 days, as shown in Figures 5C,D . The mouse thigh was inflamed after implantation, and after Day 7, the inflammation subsided without abnormal neurobehaviour.…”

Section: Biocompatibility Properties Of Bio-heasmentioning

confidence: 99%

“…Through X-ray photoelectron spectroscopy (XPS) tests, it was found that TiO2, ZrO2, HfO2, and Ta2O5 were formed during FIGURE 5 (A) Giemsa staining images of osteoblasts cultured on the surface of SLM-built BioHEA and CP-Ti, SS316L, and cast BioHEA counterpar (Ishimoto et al, 2021)t. (B) Fluorescent images of osteoblast adhesion on SLM-built bio-HEA, CP-Ti, SS316L, and cast bio-HEA (Akmal et al, 2021). (C,D) Visual evidence of mice thigh before and d after implantation (MoTa)0.2NbTiZr alloy (Akmal et al, 2021).…”

Section: Corrosion Resistancementioning

confidence: 99%

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Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility

Liu

Yang²,

Liu³

et al. 2022

Front. Bioeng. Biotechnol.

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Medical metal implants are required to have excellent mechanical properties and high biocompatibility to handle the complex human environment, which is a challenge that has always existed for traditional medical metal materials. Compared to traditional medical alloys, high entropy alloys (HEAs) have a higher design freedom to allow them to carry more medical abilities to suit the human service environment, such as low elastic modulus, high biocompatible elements, potential shape memory capability. In recent years, many studies have pointed out that bio-HEAs, as an emerging medical alloy, has reached or even surpassed traditional medical alloys in various medical properties. In this review, we summarized the recent reports on novel bio-HEAs for medical implants and divide them into two groups according the properties, namely mechanical properties and biocompatibility. These new bio-HEAs are considered hallmarks of a historic shift representative of a new medical revolution.

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Section: Biocompatibility Properties Of Bio-heasmentioning

confidence: 99%

Section: Corrosion Resistancementioning

confidence: 99%

Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility

Liu

Yang²,

Liu³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Akmal et al [46] studied the (MoTa) x NbTiZr (TiZrNbTaMo) system for various values of x. A critical concentration of x = 0.4 was determined, where higher concentrations of Mo and Ta led to increasing brittleness and elastic modulus and decreasing ductility.…”

Section: Comparison Of Mechanical Properties For Bone Implantsmentioning

confidence: 99%

“…Akmal et al studied the in vivo biocompatibility of alloys from the Mo-Ta-Nb-Ti-Zr system [46]. When their optimized alloy, the selection of which was made based on mechanical properties, was used as implant in mice, it was observed that no muscle damage or adverse effects due to potential toxicity problems occurred.…”

Section: Biocompatibility Studiesmentioning

confidence: 99%

An Overview of High-Entropy Alloys as Biomaterials

Castro

Rocha

Baptista

et al. 2021

Metals

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High-entropy alloys (HEAs) have been around since 2004. The breakthroughs in this field led to several potential applications of these alloys as refractory, structural, functional, and biomedical materials. In this work, a short overview on the concept of high-entropy alloys is provided, as well as the theoretical design approach. The special focus of this review concerns one novel class of these alloys: biomedical high-entropy alloys. Here, a literature review on the potential high-entropy alloys for biomedical applications is presented. The characteristics that are required for these alloys to be used in biomedical-oriented applications, namely their mechanical and biocompatibility properties, are discussed and compared to commercially available Ti6Al4V. Different processing routes are also discussed.

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“…In recent years, more reviews focused on diffusion studies [57], deformation behavior [58,59], corrosion [60,61], fracture and fatigue [62,63], defects and radiation resistance [64][65][66], refractory HEAs [67], HEAs composites [68] and ceramics [69] were published. Moreover, high entropy alloys have applications in different fields such as biomedical [70,71], energy [72], wear [73,74], nuclear [75,76] and creep [63], corrosion [60,[77][78][79].…”

Section: Introduction 1the History Of High Entropy Alloysmentioning

confidence: 99%

Recent Advances in Additive Manufacturing of High Entropy Alloys and Their Nuclear and Wear-Resistant Applications

Sonal

Lee

2021

Metals

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Alloying has been very common practice in materials engineering to fabricate metals of desirable properties for specific applications. Traditionally, a small amount of the desired material is added to the principal metal. However, a new alloying technique emerged in 2004 with the concept of adding several principal elements in or near equi-atomic concentrations. These are popularly known as high entropy alloys (HEAs) which can have a wide composition range. A vast area of this composition range is still unexplored. The HEAs research community is still trying to identify and characterize the behaviors of these alloys under different scenarios to develop high-performance materials with desired properties and make the next class of advanced materials. Over the years, understanding of the thermodynamics theories, phase stability and manufacturing methods of HEAs has improved. Moreover, HEAs have also shown retention of strength and relevant properties under extreme tribological conditions and radiation. Recent progresses in these fields are surveyed and discussed in this review with a focus on HEAs for use under extreme environments (i.e., wear and irradiation) and their fabrication using additive manufacturing.

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Systematic study of (MoTa) NbTiZr medium- and high-entropy alloys for biomedical implants- In vivo biocompatibility examination

Cited by 66 publications

References 34 publications

Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility

Medical high-entropy alloy: Outstanding mechanical properties and superb biological compatibility

An Overview of High-Entropy Alloys as Biomaterials

Recent Advances in Additive Manufacturing of High Entropy Alloys and Their Nuclear and Wear-Resistant Applications

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