Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients

Künzler, Tobias P.; Drobek, Tanja; Schüler, Martin; Spencer, Nicholas D.

doi:10.1016/j.biomaterials.2007.01.019

Cited by 479 publications

(427 citation statements)

References 34 publications

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“…This constitutes an interesting result given the high sensitivity of osteoblasts to roughness at different scales [7,9,[38][39][40][41] and the strong influence of fractal dimension on osteoblastic adhesion and differentiation [10]. Regarding the roughness parameters, although the lack of standardization in the measurements makes comparison difficult with other studies, the values of S a , S dr , S ds and S ci which were obtained here fall within the range of the reported values for commercial dental implants with proved high success rate [8,[42][43][44].…”

Section: Evolution Of the Surface Topography Over Etching Timementioning

confidence: 72%

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Flamant

Marro

Rovira

et al. 2016

Journal of the European Ceramic Society

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Rough surfaces have been shown to promote osseointegration, which is one of the keys for a successful dental implantation. Among the diverse treatments proposed to roughen zirconia, hydrofluoric acid (HF) etching appears to be a good candidate, however little is known about this process. In this work, the effect of HF concentration and etching time on the surface topography and chemistry of yttria-stabilized zirconia was assessed.Besides, to understand the etching mechanism, the reaction products present in solution and on the surface were characterized. The results indicate suitable parameters for a fast and uniform roughening of zirconia. The formation of adhered fluoride precipitates on the surface is reported for the first time and highlights the importance of cleaning after etching. Finally, it is shown that monitoring the time allows controlling the surface roughness, smooth-rough transition and fractal dimension, which should make possible the fabrication of implants with an optimal topography.

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Section: Evolution Of the Surface Topography Over Etching Timementioning

confidence: 72%

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Flamant

Marro

Rovira

et al. 2016

Journal of the European Ceramic Society

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“…Not only the chemistry but also the topography of the surface of a biomaterial has a major influence on the interaction of biomaterials with cells starting initially with cell attachment which determines the subsequent processes like cell adhesion, spreading, morphology, migration, proliferation and differentiation [39]. Generally, the response of cells to surface topography differs according to cell type.…”

Section: Discussionmentioning

confidence: 99%

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

Neel

Chrzanowski

Valappil

et al. 2009

Journal of Non-Crystalline Solids

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a b s t r a c tThis study investigates the effect of doping a high calcium oxide containing metaphosphate glass series (CaO) 40 (Na 2 O) 10 (P 2 O 5 ) 50 with TiO 2 (1, 3, and 5 mol%). TiO 2 incorporation increased the density and glass transition temperature while reduced the degradation rate (5 mol% in particular) by twofold compared with (CaO) 30 system reported previously. This has been confirmed by ion release and the minimal pH changes. TiP 2 O 7 , NaCa(PO 3 ) 3 and CaP 2 O 6 phases were detected for all TiO 2 -containing ceramics. XPS showed that the surface is composed of Ca, P, and Ti. Ti was recognized mainly as TiO 2 , but its total amount was lower than theoretical values. 31 P magic angle spinning (MAS) NMR showed a downfield shift of the 31 P lineshape with increasing TiO 2 , interpreted as an effect of the titanium cation rather than an increase in the phosphate network connectivity. FTIR showed that incorporation of TiO 2 increased the strength of the phosphate chains, and the O/P ratio while introducing more Q 1 units into the structure at the expense of the Q 2 units. There were no differences, however, in surface topography roughness and free energies between these glasses. These results suggested that TiO 2 and CaO were acting synergistically in producing glasses with controllable bulk and structural properties.

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“…roughness) on material surfaces are also crucial in cell and tissue responses to biomaterials. Indeed, surface roughness has shown to alter fibroblast proliferation on aluminiun, titanium and titanium alloys substrates [60][61][62] , and strongly influence bacterial attachment to nitinol, titanium and glass surfaces [63][64][65][66] . Overall, the three functionalization strategies displayed the same value of R a (~ 30 nm; Table 2), slightly increasing the original R a of control samples (~ 25 nm; Table 2).…”

Section: Physicochemical Characterization Of the Surfacesmentioning

confidence: 99%

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

et al. 2015

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Dental implant failure can be associated to infections which develop into periimplantitis. In order to reduce biofilm formation, several strategies focusing on the use of antimicrobial peptides (AMP) have been studied. To covalently immobilize these molecules onto metallic substrates several techniques have been developed, including silanization and polymer brush prepared by surface-initiated atom transfer radical polymerization (ATRP), with varied peptide binding yield and antibacterial performance. The aim of the present study was to compare the efficiency of these methods to immobilize the lactoferrin-derived hLf1-11 antibacterial peptide onto titanium, and evaluate their antibacterial activity in vitro.Smooth titanium samples were coated with hLf1-11 peptide under three different conditions: silanization with APTES, and polymer brush based coatings with two different silanes. Peptide presence was determined by X-ray photoelectron spectroscopy and the mechanical stability of the coatings was studied under ultrasonication. The LDH assays confirmed that HFFs viability and proliferation were no affected by the treatments. The in vitro antibacterial properties of the modified surfaces were tested with two oral strains (Streptococcus sanguinis and Lactobacillus salivarius) showing an outstanding reduction. A higher decrease in bacterial attachment was noticed when samples were modified by ATRP methods compared to silanization. This effect is likely due to the capacity to immobilize more peptide on the surfaces using polymer brushes and the non-fouling nature of polymer PDMA segment.3

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Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients

Cited by 479 publications

References 34 publications

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

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