Certain substance use disorders, such as nicotine, opioid, and alcohol use disorders, have efficacious pharmacotherapies (National Institute on Drug Abuse, 2014). Medications for these disorders largely target neurotransmitter systems affected by the substance of abuse. Behavioral addictions, in contrast, do not involve ingestion of any substance, and their neurophysiology remains elusive. To date, the U.S. Food and Drug Administration (FDA) has not approved any medication to treat a behavioral addiction. However, initial experimental trials of medications for gambling disorder and other puta tive behavioral addictions have been conducted. In this chapter, we review research on pharmacother apy for gambling disorder, Internet gaming disorder, and Internet addiction. We also briefly discuss treat ments for other potential behavioral addictions (e.g., shopping, eating), although much less data exist on these conditions.Dr. Nancy Petry passed away on July 18, 2018. She contributed to all aspects of preparing this chapter for publication. We feel fortunate for all her contributions to the field of behavioral addictions and for her mentorship.