Objective. To establish associations of a high level of depression with certain parameters of attitudes towards medical care in women in an open urban population. Subjects and methods. A cross-sectional epidemiological study was conducted on a representative sample of women aged 25–64, formed from the electoral lists of citizens of the city of Tyumen in the amount of 1000 people, the response was 70.3%. The levels of depression and the attitude of the population to medical care were determined using the standard WHO MONICA-MOPSY questionnaire. Results. About a third of women in the open urban population showed the presence of depression, over four age decades of life, a tendency was established for a decrease in the prevalence of D from its low level to an average and further to a high level, a tendency to an increase in the prevalence of D from the fourth to the sixth decade of life was noted. Half of the women in the open population, regardless of age, only with severe pain in the region of the heart would go to the doctor and trust specialized studies more, and only a third part would go to the doctor if there was any pain in the region of the heart and trust the examination of the doctor. One-fifth of the population was more guided by their well-being, and not by the doctor's opinion. In the presence of a high level of depression in women of the open population, associations with the parameters of attitude to medical care were established and the minimum activity in the prevention and treatment of CVD was determined. Conclusion. Thus, the results of the study obtained on an open urban population, which identified the most vulnerable categories of women with a high level of depression, can serve as a scientific basis for the formation of comprehensive preventive programs to reduce the risks of developing CVD in female populations of medium urbanized cities of Western Siberia.