The Yubileinoe large gold deposit, located at the southern end of the Magnitogorsk megazone, is the only known representative of the Au–porphyry systems in the Southern Urals. It is genetically related to granitoids formed in a suprasubduction setting under mature oceanic island arc environment/setting. The obtained isotope (Pb–Pb and δ34S) data indicate the input of mineral-forming components into the Au–porphyry system of the deposit, mainly from granitoid melts, confirming a common source of ore material and ore-bearing granitoids. The geochemical and isotopic characteristics of granitoids indicate the leading role in their genesis of the crustal source, which is considered Late Precambrian continental crust.