Systemic abnormalities in liver disease

Abstract

Systemic abnormalities often occur in patients with liver disease. In particular, cardiopulmonary or renal diseases accompanied by advanced liver disease can be serious and may determine the quality of life and prognosis of patients. Therefore, both hepatologists and non-hepatologists should pay attention to such abnormalities in the management of patients with liver diseases.

Lymphopenia in Patients with Single-ventricle Heart Disease after the Fontan Operation

“…16 In addition, splenic sequestration of white blood cells from hypersplenism likely also contributes to leukopenia in those with cirrhosis. 14,17 Our study cannot exclude subclinical lymphocyte loss in the stool in setting of elevated central venous pressure as a possible etiology. However, lymphocyte count was not associated with inferior vena cava pressure.…”

“…Table 3 shows the results of catheterization and CBCD. At catheterization, the median cardiac index was mildly decreased at 2.9 L/min/m 2 (1.8-6.2) and median inferior vena cava (IVC) pressure was 13 mm Hg (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The median ALC was 1.5 3 10 3 /lL (0.8-4.5).…”

“…Several mechanisms have been proposed to explain the link between liver fibrosis and lymphopenia . First, patients with cirrhosis may have circulating serum factors that inhibit the maturation of hematopoietic progenitor cells.…”

“…Abnormal expression of the Fas antigen involved in apoptosis has been proposed to explain this finding . In addition, splenic sequestration of white blood cells from hypersplenism likely also contributes to leukopenia in those with cirrhosis …”

Manifestações dermatológicas em uma casuística de doença hepática crônica de um hospital de referência em Belém, Estado do Pará, Brasil

“…O fígado é o principal órgão para o metabolismo de proteínas, carboidratos, gordura e fármacos, bem como para a remoção de hormônios e outras substâncias 3 . As atividades metabólicas do fígado exigem um rico suprimento sanguíneo para o transporte destes substratos.…”