Systemic Administration of Allogeneic Cord Blood Mononuclear Cells in Adults with Severe Acute Contusion Spinal Cord Injury: Phase 1/2a Pilot Clinical Study–Safety and Primary Efficacy Evaluation

Smirnov, Vladimir; Радаев, С. М.; Morozova, Yana V.; Ryabov, S. I.; Yadgarov, M. Yа.; Bazanovich, S. A.; Lvov, Ivan; Talypov, Aleksandr; Grin, A. A.

doi:10.1016/j.wneu.2022.02.004

Cited by 12 publications

(9 citation statements)

References 56 publications

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“…In 2022, Smirnov et al [ 40 ] published the results of a phase I/IIa clinical trial using HUCBCs via intravenous injections to treat 10 patients with acute SCI (AIS A or B). Four injections were administered to each patient within three days post-injury.…”

Section: Reviewmentioning

confidence: 99%

Stem Cell Therapy for Spinal Cord Injury: A Review of Recent Clinical Trials

Damianakis¹,

Benetos²,

Evangelopoulos³

et al. 2022

Cureus

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Spinal cord injury (SCI) remains an incurable, life-changing neurological condition, causing permanent loss of motor and sensory function in millions of people worldwide and affecting them in every aspect of their personal and social life. In the last two decades, after its success in various fields of medicine, stem cell therapy has been investigated in the research field as a potential treatment for SCI. This review focuses on the pathophysiology of SCI, the characteristics of the different stem cell therapies used for its treatment, and the results of these therapies in recently published clinical trials.

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Section: Reviewmentioning

confidence: 99%

Stem Cell Therapy for Spinal Cord Injury: A Review of Recent Clinical Trials

Damianakis¹,

Benetos²,

Evangelopoulos³

et al. 2022

Cureus

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“…However, a total of 419 adverse events were found, two of which may be related to cell therapy, but both were mild and clinically unimportant events. 28 5 | MORPHOLOGICAL CHANGES OF SCI AFTER TRANSPLANTATION…”

Section: Behavioral Results Of Patients In Clinical Trialsmentioning

confidence: 99%

“…Cord blood sample treatment applied to rhesus monkeys promoted obvious functional recovery of motor parts. However, a total of 419 adverse events were found, two of which may be related to cell therapy, but both were mild and clinically unimportant events 28 …”

Section: Behavioral Improvement In Sci Patients After Transplantationmentioning

confidence: 99%

“…Combined treatment is becoming increasingly more important and necessary, for example, UCBs combined with gene transfect and electric stimulation therapy for treatment of SCI. of UCBs 1-6 weeks 9,10,12 Behavioral improvement Effective 9,11,14,15,[17][18][19][20][21][22][23][24][25][26]38 Effective 27,28 Morphological changes Spinal infarct ↓ 9,15,17,23,25,29,30 Myelinated fibers ↑ 15,22,29,30,34,35 ↑ 31 Axons grow ↑ [24][25][26]33,34,36 Fibroblast numbers ↓ 12,34,36 White matter space…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

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Therapeutic effect of umbilical cord blood cells on spinal cord injury

Zhang

Steven

Liao

2023

Ibrain

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Spinal cord injury (SCI) is a nervous system disease characterized by sensory and motor dysfunction, axonal apoptosis, decreased vascular density, and inflammation. At present, surgical treatment, drug treatment, and cell therapy can be used. Surgical treatment can improve motor and independent function scores, and drug treatment can promote the recovery of neurons in the spinal cord, but only improve symptoms. Complete recovery of SCI has not yet been achieved. However, the differentiation of stem cells brings hope for the treatment of SCI. Umbilical cord blood cells (UCBs) are ethically readily available and can repair neuronal damage. However, it is still unclear how they can improve symptoms and repair nerve severity. In this paper, the role of UCBs in the treatment of SCI is described in detail from different aspects such as behavior, morphology, and molecular expression changes, so as to provide new ideas and theoretical directions for future research.

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“…Aside from animal models, clinical trials also provide support for the effectiveness of umbilical cord blood during spinal cord injury therapy. While there is a lack of clinical trials provided for hCB-MSC treatment, transplantation is a supported method regarding safety and primary efficacy [33,34]. During one such study by Yao and colleagues, 25 subjects participated in a human umbilical cord blood stem cell transplantation -through both lumbar puncture and intravenous administration-to evaluate its long-term effects during long-term spinal cord rehabilitation.…”

Section: Umbilical Cord Blood Stem Cell Therapymentioning

confidence: 99%

The Applications of Human Umbilical Cord Mesenchymal Stem Cells to Treat Spinal Cord Injuries

Gallicchio¹

2023

JRMBR

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Due to the morbidity and resulting lifestyle changes of Spinal Cord Injuries (SCI), there has been an extensive need to evaluate potential treatments. Mesenchymal cells hold the capacity to address both the primary and secondary mechanisms of SCI. Human Umbilical Cord stem cells (hUC), in particular, show promise due to their rapid proliferation, immunological properties, and pluripotent capacity. These hUC-MSC can be isolated from the umbilical Cord Blood (hCB) and Wharton’s jelly, a viscous gel that maintains the umbilical cord’s integrity. While Wharton’s jelly-derived hUC-MSCs appear to have a greater capability for the treatment of SCI due to their increased proliferation, hCB-MSC additionally has long-term therapeutic potential in clinical trials.

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Systemic Administration of Allogeneic Cord Blood Mononuclear Cells in Adults with Severe Acute Contusion Spinal Cord Injury: Phase 1/2a Pilot Clinical Study–Safety and Primary Efficacy Evaluation

Cited by 12 publications

References 56 publications

Stem Cell Therapy for Spinal Cord Injury: A Review of Recent Clinical Trials

Stem Cell Therapy for Spinal Cord Injury: A Review of Recent Clinical Trials

Therapeutic effect of umbilical cord blood cells on spinal cord injury

The Applications of Human Umbilical Cord Mesenchymal Stem Cells to Treat Spinal Cord Injuries

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