Systemic administration of baclofen inhibits water intake in rats

Ebenezer, Ivor S.; Houston, Abigail J.; Crook, Tracy J.

doi:10.1016/0306-3623(92)90097-4

Cited by 15 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results obtained in this study on the effects of baclofen injected into the LPBN on water intake in dehydrated rats are therefore similar to those previously reported [33]. Ebenezer et al [34] also demonstrated that systemic administration of baclofen had no effects on water intake in fluid replete rats. Interestingly, in the present study was demonstrated that bilateral injection of baclofen into the LPBN induced water and 0.3 M NaCl intake (150 – 210 min of test) in a two-bottle test in fluid replete rats.…”

Section: Discussionsupporting

confidence: 91%

“…Peripheral administration of baclofen reduce water deprivation-induced water intake and reduce water intake in rats pretreated with a hypertonic solution of NaCl [33,34]. The results obtained in this study on the effects of baclofen injected into the LPBN on water intake in dehydrated rats are therefore similar to those previously reported [33].…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

et al. 2013

View full text Add to dashboard Cite

BackgroundActivation of GABAB receptors with baclofen into the lateral parabrachial nucleus (LPBN) induces ingestion of water and 0.3 M NaCl in fluid replete rats. However, up to now, no study has investigated the effects of baclofen injected alone or combined with GABAB receptor antagonist into the LPBN on water and 0.3 M NaCl intake in rats with increased plasma osmolarity (rats treated with an intragastric load of 2 M NaCl). Male Wistar rats with stainless steel cannulas implanted bilaterally into the LPBN were used.ResultsIn fluid replete rats, baclofen (0.5 nmol/0.2 μl), bilaterally injected into the LPBN, induced ingestion of 0.3 M NaCl (14.3 ± 4.1 vs. saline: 0.2 ± 0.2 ml/210 min) and water (7.1 ± 2.9 vs. saline: 0.6 ± 0.5 ml/210 min). In cell-dehydrated rats, bilateral injections of baclofen (0.5 and 1.0 nmol/0.2 μl) into the LPBN induced an increase of 0.3 M NaCl intake (15.6 ± 5.7 and 21.5 ± 3.5 ml/210 min, respectively, vs. saline: 1.7 ± 0.8 ml/210 min) and an early inhibition of water intake (3.5 ± 1.4 and 6.7 ± 2.1 ml/150 min, respectively, vs. saline: 9.2 ± 1.4 ml/150 min). The pretreatment of the LPBN with 2-hydroxysaclofen (GABAB antagonist, 5 nmol/0.2 μl) potentiated the effect of baclofen on 0.3 M NaCl intake in the first 90 min of test and did not modify the inhibition of water intake induced by baclofen in cell-dehydrated rats. Baclofen injected into the LPBN did not affect blood pressure and heart rate.ConclusionsThus, injection of baclofen into the LPBN in cell-dehydrated rats induced ingestion of 0.3 M NaCl and inhibition of water intake, suggesting that even in a hyperosmotic situation, the blockade of LPBN inhibitory mechanisms with baclofen is enough to drive rats to drink hypertonic NaCl, an effect independent of changes in blood pressure.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

et al. 2013

View full text Add to dashboard Cite

show abstract

“…A modified method to the previously described protocol was used (14). First, mice were individually housed and habituated to water restriction.…”

Section: Methodsmentioning

confidence: 99%

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7

Hayashi

Cottam²,

Chan³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

“…It is not clear why there was a small but significant decrease in food intake in some of early feeding trials in the present study. We have previously demonstrated that this dose of baclofen was not aversive to rats in a 2-bottle taste aversion test (Ebenezer et al, 1992). However, it is noteworthy that in this study baclofen was administered immediately after each feeding session and it is possible that the drug may have had some adverse effects, which, in turn, may have affected food consumption in early trials.…”

Section: Discussionmentioning

confidence: 97%

The effects of repeated intraperitoneal administration of the GABA_Breceptor agonist baclofen on body weight in rats maintained on a restricted feeding schedule

Ebenezer

2023

Preprint

Self Cite

View full text Add to dashboard Cite

It has previously been shown that chronic systemic administration of the GABAB agonist baclofen reduces body weight in free feeding rats but has no effect on long term food intake. The present study was conducted to extend these observations by investigating the effects of baclofen on body weight, food intake and water consumption in rats maintained on a restricted feeding schedule. The rats were allowed free access to food for 3 hours each day and injected intraperitoneally once daily over a period of 11 days with baclofen (4 mg / kg) or saline (Control Group) immediately after each feeding session. Baclofen treatment produced small decreases in food intake on Days 2, 4 and 5 compared with control animals (P<0.05) but there were no differences between the 2 groups on Days 6 to 11. Baclofen did not affect prandial water intake. However, baclofen significantly decreased body weight gain of the animals starting 3 days after the initiation of treatment. During the subsequent 9 days both groups received no treatments. However, the baclofen group continued displaying significant reductions in body weight gain (P<0.01) but there were no significant differences in food and water consumption between the 2 groups of animals. The results of this study indicate that repeated administration of baclofen to food-restricted rats for 11 days reduces body weight and that the effects persist when the drug is withdrawn. While it is possible that the decrease in food intake during the early period of the experiment may have been partly responsible for the reduction in body weight in the baclofen treated animals, the observation that these rats displayed reduction in body weight during the latter part of the study when there was no significant differences in food intake between the 2 groups, suggests that the drug decreases body weight independently of its effects on food consumption.

show abstract

Systemic administration of baclofen inhibits water intake in rats

Cited by 15 publications

References 20 publications

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7

The effects of repeated intraperitoneal administration of the GABA_Breceptor agonist baclofen on body weight in rats maintained on a restricted feeding schedule

Contact Info

Product

Resources

About

Systemic administration of baclofen inhibits water intake in rats

Cited by 15 publications

References 20 publications

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chloride intake during cell dehydration

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7

The effects of repeated intraperitoneal administration of the GABABreceptor agonist baclofen on body weight in rats maintained on a restricted feeding schedule

Contact Info

Product

Resources

About

The effects of repeated intraperitoneal administration of the GABA_Breceptor agonist baclofen on body weight in rats maintained on a restricted feeding schedule