Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats

Guimarães, Morgana Rodrigues; Aquino, Sabrina García de; Curylofo, Fabiana de Almeida; Tasso, Camilla Olga; Rocha, Fernanda Regina Godoy; Medeiros, Marcell Costa de; Pizzol, José Paulo de; Cerri, Paulo Sérgio; Romito, Giuseppe Alexandre; Rossa, Carlos

doi:10.1007/s00784-018-2755-9

Cited by 42 publications

(41 citation statements)

References 39 publications

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“…233 Therefore, as for the antioxidant resveratrol, experimental periodontitis models (in which development of periodontal disease and periodontal destruction is effective) have been used to assess the effects of curcumin on periodontal tissues. 234 The experimental ligature-induced periodontitis model in rats, discussed in section 3.1.3, has been induced/modified by the addition of lipopolysaccharide injections or induction of type 2 diabetes (or, more accurately, hyperglycemia). Natural curcumin presents relatively poor pharmacological properties, such as poor bioavailability, high insolubility in water, and a short half-life in plasma; therefore, several studies have compared natural curcumin with chemically modified analogs or chemically modified curcumins, which present better chemical characteristics.…”

Section: Curcuminmentioning

confidence: 99%

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Sczepanik

Grossi

Casati

et al. 2020

Periodontology 2000

354

244

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Periodontitis is a highly prevalent disease. As it progresses, it causes serious morbidity in the form of periodontal abscesses and tooth loss and, in the latter stages, pain. It is also now known that periodontitis is strongly associated with several nonoral diseases. Thus, patients with periodontitis are at greater risk for the development and/or exacerbation of diabetes, chronic obstructive pulmonary disease, and cardiovascular diseases, among other conditions. Although it is without question that specific groups of oral bacteria which populate dental plaque play a causative role in the development of periodontitis, it is now thought that once this disease has been triggered, other factors play an equal, and possibly more important, role in its progression, particularly in severe cases or in cases that prove difficult to treat. In this regard, we allude to the host response, specifically the notion that the host, once infected with oral periodontal pathogenic bacteria, will mount a defense response mediated largely through the innate immune system. The most abundant cell type of the innate immune system – polymorphonuclear neutrophils – can, when protecting the host from microbial invasion, mount a response that includes upregulation of proinflammatory cytokines, matrix metalloproteinases, and reactive oxygen species, all of which then contribute to the tissue damage and loss of teeth commonly associated with periodontitis. Of the mechanisms referred to here, we suggest that upregulation of reactive oxygen species might play one of the most important roles in the establishment and progression of periodontitis (as well as in other diseases of inflammation) through the development of oxidative stress. In this overview, we discuss both innate and epigenetic factors (eg, diabetes, smoking) that lead to the development of oxidative stress. This oxidative stress then provides an environment conducive to the destructive processes observed in periodontitis. Therefore, we shall describe some of the fundamental characteristics of oxidative stress and its effects on the periodontium, discuss the diseases and other factors that cause oxidative stress, and, finally, review potentially novel therapeutic approaches for the management (and possibly even the reversal) of periodontitis, which rely on the use of therapies, such as resveratrol and other antioxidants, that provide increased antioxidant activity in the host.

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Section: Curcuminmentioning

confidence: 99%

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Sczepanik

Grossi

Casati

et al. 2020

Periodontology 2000

354

244

View full text Add to dashboard Cite

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“…After 6 and 12 days, all animals were sacrificed by anesthetic overdose. The maxillary jaws were hemisected, and one half of the maxillae including molars with their surrounding tissues were fixed in 4% paraformaldehyde for 48 h and stored in 70% ethanol for analysis of bone resorption by micro-CT. Later, these samples (6 hemimaxillae per group and time point) were decalcified in EDTA (10%, 0.5 M) for 2 months at RT [25][26][27] and embedded in paraffin for histological processing for stereometric and immunohistochemical (IHC) analyses. The other half of maxillae (6 hemimaxillae per group and time point) had the gingival tissues around the maxillary first molars carefully dissected for extraction of total RNA for real-time polymerase chain reaction (RT-qPCR).…”

Section: Methodsmentioning

confidence: 99%

Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies

Nogueira

Nokhbehsaim

Tekin

et al. 2020

Mediators of Inflammation

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Resistin, a proinflammatory adipokine, is elevated in many inflammatory diseases. However, little is known about its performance in periodontitis. The present study is aimed at evaluating resistin expression and synthesis in periodontal cells and tissues under inflammatory/microbial stress in addition to its effects on the periodontium. In vivo, 24 male rats were randomly divided into two groups: control and ligature-induced periodontal disease. After 6 and 12 days, animals were sacrificed to analyze gene expression of adipokines, bone loss, inflammation, and resistin synthesis. In vitro, human periodontal ligament (PDL) fibroblasts were used to evaluate the expression of resistin after inflammatory stimuli. In addition, PDL fibroblasts were exposed to resistin to evaluate its role on soft and hard tissue metabolism markers. The periodontitis group demonstrated significant bone loss, an increase in the number of inflammatory cells and vascular structures, an increase in resistin expression and synthesis, and a decrease in the expression of adiponectin, leptin, and its functional receptor. PDL fibroblasts showed a significant increase in resistin expression and synthesis in response to the inflammatory stimulus by IL-1β. Resistin induced an increase in cytokine expression and a decrease in the regulation of some hard tissue and matrix formation genes in PDL fibroblasts. These data indicate that resistin is produced by periodontal cells and tissues, and this effect is enhanced by inflammatory stimuli. Moreover, resistin seems to interfere with soft and hard tissue metabolism during periodontitis by reducing markers related to matrix formation and bone tissue.

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“…Of these, IL-1, IL-6, and IL-17 alone or in synergy with IL-1 β , TNF- α , toll-like receptors, and prostaglandin E 2 (PGE 2 ) have been shown to stimulate gingival fibroblasts, epithelial cells, and macrophages to control homeostasis of periodontal tissues and to release proinflammatory mediators for tissue homeostasis [ 3 , 4 ]. These inflammatory cytokines promote the expression of receptor activator of nuclear factor-kappa B (NF- κ B) ligand (RANKL) in the stromal cells and osteoblasts [ 5 ] that, together with osteoprotegerin, represents the key pathways that control alveolar bone resorption [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL‐1β, and TNF‐α in Chronic Periodontitis Patients

Mohammad

2020

BioMed Research International

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Curcumin exhibits antibacterial, antioxidant, and anti-inflammatory effects and has been suggested as a treatment for inflammatory diseases. The study is aimed at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc, copper, and magnesium) and proinflammatory cytokines (IL-1β and TNF-α) in chronic periodontitis patients. Ninety subjects with an age of 25-54 were included in this study. From the total number, 30 subjects with healthy periodontium (control group) ( mean age = 37.30 ± 7.08 ) were employed for the sole purpose of obtaining the normal mean values of clinical, chemical, and immunological parameters, and 60 with chronic periodontitis ( mean age = 36.73 ± 6.22 ) were divided randomly into 2 groups, of which each group included 30 subjects. Group A received scaling and root planing SRP and curcumin gel injection covered by Coe pack for 7 days, and group B received SRP alone covered by Coe pack. Clinical parameters (plaque index, gingival index, bleeding on probing, pocket depth, and clinical attachment loss measurements) and blood samples were collected before and after 1 month of treatment to measure serum levels of zinc, copper, magnesium, IL-1β, and TNF-α. The results showed significant micronutrient alteration and increase of proinflammatory cytokines in the chronic periodontitis group as compared to healthy control ( P ≤ 0.05 ), and curcumin gel had a significant effect on the reduction of IL-1β, TNF-α, copper, and clinical parameters ( P ≤ 0.05 ) and increase of zinc and magnesium levels after 1 month as compared to baseline ( P ≤ 0.05 ), nearly the same pattern for group B but with nonsignificant differences for Zn ( P > 0.05 ). In conclusion, curcumin gel resulted in a more significant reduction in clinical parameters, inflammatory mediators, and copper and increase of zinc and magnesium levels as compared to SRP alone.

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Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats

Cited by 42 publications

References 39 publications

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies

Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL‐1β, and TNF‐α in Chronic Periodontitis Patients

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