Systemic AL kappa chain amyloidosis in a captive Bornean orangutan (Pongo pygmaeus)

Iwaide, Susumu; Takemae, Hitoshi; Oba, Mami; Owaku, Kenta; Kobayashi, Natsumi; Itoh, Yoshiyuki; Kozono, Takuma; Hisada, Miki; Miyabe-Nishiwaki, Takako; Watanuki, Koshiro; Yanai, Tokuma; Inoue, Hisafumi; Murakami, Tomoaki

doi:10.1016/j.rvsc.2024.105315

Research in Veterinary Science

2024

DOI: 10.1016/j.rvsc.2024.105315

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Systemic AL kappa chain amyloidosis in a captive Bornean orangutan (Pongo pygmaeus)

Susumu Iwaide,

Hitoshi Takemae,

Mami Oba

et al.

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2024

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Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis

Kobayashi,

Usui,

Elbadawy

et al. 2024

IJMS

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Although hyperplasia of the anorectal transitional zone (TZ) has been reported in mouse models of ulcerative colitis, the mechanisms underlying this phenomenon are not fully understood. We characterized keratin subtypes and examined the expression of stem cell markers in the TZ. Dextran sodium sulfate-treated mice showed abnormal repair of the anorectal region, which consisted of mixed hyperplastic TZ and regenerating crypts. Liquid chromatography-tandem mass spectrometry from the paraffin-embedded TZ in the treated mice revealed that the major keratins were type I cytokeratin (CK)13 and type II CK5, but notable expression of type I CK10 and CK42 and type II CK1, CK4, CK6a, CK8, and CK15 was also detected. Hyperplastic TZ was characterized by the expression of tumor protein 63, sex-determining region Y-box 2 (SOX2), SOX9, and leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5). Lgr5 was highly expressed in the TZ in the early stages of colitis, followed by higher expression levels of SOX2. The TZ-derived organoids expressed LGR5, SOX2, and SOX9. The present study suggests that transitional zones showing abnormal keratin assembly and stem cell activation may interfere with rectal crypt regeneration, leading to pathological anorectal remodeling in severe colitis.

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Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis

Kobayashi,

Usui,

Elbadawy

et al. 2024

IJMS

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show abstract

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Systemic AL kappa chain amyloidosis in a captive Bornean orangutan (Pongo pygmaeus)

Cited by 1 publication

References 43 publications

Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis

Anorectal Remodeling in the Transitional Zone with Increased Expression of LGR5, SOX9, SOX2, and Keratin 13 and 5 in a Dextran Sodium Sulfate-Induced Mouse Model of Ulcerative Colitis

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