Systemic allergic dermatitis after patch testing with cinchocaine (dibucaine) and topical corticosteroids

Silva, Catarina Alves da; Paulsen, Evy

doi:10.1111/cod.13290

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Tetracaine‐HCl has been rarely reported as a cause of systemic allergic dermatitis due to systemic absorption from urethral 7,8 and rectal 9 mucosae and never from patch testing. Recently Alves da Silva et al described the case of systemic allergic dermatitis several days after patch testing in a patient sensitized to cinchocaine and corticosteroids 3 . The shorter latency observed in our patient could be due to the absence of allergy to corticosteroids, notably able to delay allergic reactions.…”

Section: % D2 D4supporting

confidence: 45%

“…Systemic allergic dermatitis is defined as systemic reactivation of allergic contact dermatitis (ACD) by generalized hematogenous dissemination due to ingestion, inhalation, or injection of the responsible contact allergen or a cross‐reacting compound 1 . However, generalized dissemination of ACD from the primary contact site via blood vessels is rarely described also for mucocutaneous contact 2 and only exceptionally due to patch testing 3 . Herein we report a case of systemic allergic dermatitis during tetracaine‐hydrochloride (HCl) patch testing.…”

Section: % D2 D4mentioning

confidence: 97%

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Systemic allergic dermatitis during tetracaine hydrochloride patch testing

et al. 2021

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leukoderma." 3 Depigmentation from chemicals may be associated with an initial instance of allergic contact dermatitis and appears to be due to the activation of melanocyte-specific autoimmunity, as also seen in non-chemically-induced vitiligo. 3 Pantoprazole and rabeprazole, which are members of a highly sensitizing group of chemicals, may cause an airborne pattern of contact dermatitis. 1,4 This inflammation can subsequently lead to the Koebner phenomenon, which can result in the occurrence of vitiligo in people with genetic susceptibility. Our case serves as an additional example of chemical-induced vitiligo, either direct exposure or airborne allergic contact dermatitis to PPIs. The actual mechanism of melanocyte loss in our patient is thought to be PPIs initially absorbed into skin by airborne exposure, leading to sensitization and then melanocyte loss by cytotoxic and autoreactive CD8+ T cells. Previous study 2 reported a potential melanogenesis-inhibitory effect of PPIs by reducing melanin content and tyrosinase activity levels in melanocytes and by inhibiting H+/K + -ATPase at the melanocytic cytoplasmic membrane. However, these explanations cannot explain PPI-induced vitiligo fully because the key pathogenesis in vitiligo is the loss of melanocytes rather than decreased melanin production. Herein, we suggest that PPIs most likely lead to the apoptosis of melanocytes by modifying the pH gradient and enhancing oxidative stress in melanocytes, possibly resulting in melanocyte-specific autoimmunity. 5 In summary, this case highlights the first report of PPI-induced vitiligo from occupational exposure and the potential of PPIs to augment melanocyte-specific autoimmunity.

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Section: % D2 D4supporting

confidence: 45%

Section: % D2 D4mentioning

confidence: 97%

Systemic allergic dermatitis during tetracaine hydrochloride patch testing

et al. 2021

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“…We identified 12 SCD cases due to topical anaesthetics, as previously compiled by de Groot, 4 involving cinchocaine (8/12), tetracaine (3/12), and lidocaine (1/12). Most cases presented after perianal administration (9/12) and as symmetric drug‐related intertriginous and flexural exanthema (SDRIFE) and Baboon syndromes (7/12) 7–13 …”

Section: Discussionmentioning

confidence: 99%

Benzocaine‐induced systemic contact dermatitis: A case report

Miñarro,

Guerrero,

Robaina

et al. 2023

Contact Dermatitis

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“…67,68,[79][80][81] The most characteristic manifestation of systemic contact dermatitis is the so-called baboon syndrome. [82][83][84][85] It presents as diffuse pink or dark violet erythema of the buttocks and inner thighs (Fig. 5), like an inverted triangle or V-shaped, resembling the red bottom of a baboon, often accompanied by dermatitis in the axillae and sometimes other body folds.…”

Section: Systemic Contact Dermatitismentioning

confidence: 99%

“…The most characteristic manifestation of systemic contact dermatitis is the so-called baboon syndrome 82–85 . It presents as diffuse pink or dark violet erythema of the buttocks and inner thighs (Fig.…”

Section: Allergic Contact Dermatitis From Topical Drugsmentioning

confidence: 99%