Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma

Deng, Sisi; Zhi, Zhang; Lü, Xiaoli; Zhou, Qi; Xia, Shilin; Li, Mi

doi:10.18632/aging.103836

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…The invasion and migration of tumor cells lead to the poor prognosis and recurrence of diseases. Studies have shown that the imbalance of GIMAP family expression is related to the development of lung cancer ( 30 , 31 ). Based on the prognostic value of the GIMAP family in lung cancer, it is possible to understand the mechanism driving the occurrence and development of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

et al. 2021

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ObjectiveSeveral studies have demonstrated the impacts of GTPases of immunity-associated proteins (GIMAPs) on malignant cells. However, the mechanisms through which Gimap5 regulates lung cancer cells are yet to be thoroughly investigated in the literature. Our study aimed to investigate the function of Gimap5 in the development of lung cancer.MethodsThe expression levels of the GIMAP family were analyzed in lung cancer patients of various cancer databases and lung cancer cell lines. After the survival rates of the cells were analyzed, we constructed Gimap5 over-expressed lung cancer cell lines and assessed the effects of Gimap5 on cell migration, cell invasion, cell proliferation and the epithelial-mesenchymal transition (EMT). We later screened the interacting proteins of Gimap5 using Co-IP combined with mass spectrometry and then analyzed the expression and distribution of M6PR, including its impacts on protein-arginine deiminase type-4 (PADI4).ResultsFindings indicated that GIMAP family expression decreased significantly in lung cancer cell lines. We also noticed that the downregulation of the GIMAP family was related to the poor prognosis of lung cancer patients. Our experimental results showed that Gimap5 could inhibit the migration, invasion, proliferation and EMT of lung cancer cell lines. Moreover, we found that Gimap5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4.ConclusionOur research suggested that Gimap5 could inhibit the growth of lung cancer by interacting with M6PR and that it could be a potential biomarker for the diagnosis and prognosis of lung cancer.

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Section: Discussionmentioning

confidence: 99%

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

et al. 2021

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“… 5 Studies on the association of GIMAPs with individual cancers and diseases have identified the GIMAP family as a potential diagnostic and prognostic biomarker of lung adenocarcinoma. 6 Additionally, the dysregulation of GIMAP5 and GIMAP6 has been reported in hepatocellular carcinoma. GIMAP family is also closely related to tumour immunity.…”

Section: Introductionmentioning

confidence: 99%

GIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy

Qin¹,

Li²,

Huang³

et al. 2022

JIR

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Background: GIMAP, a GTP enzyme of immune-related proteins, plays a crucial role in immune mechanisms. Investigating GIMAP7 expression in pan-cancer can provide efficient guidance for predicting clinical prognosis and identifying novel immunotherapy targets. Methods: Gene expression in different tumour types and stages was analysed based on The Cancer Genome Atlas and the Genotype-Tissue Expression database. An immunohistochemical assay was used to explore the differences in GIMAP7 protein levels in different tumour types and stages. Further, the cBioPortal was used to obtain the genetic variation characteristics of GIMAP7. Kaplan-Meier analysis and multivariable Cox regression analysis were performed to assess the prognostic value of GIMAP7. The pathways affected by GIMAP7 were studied based on gene set enrichment analysis, and the correlation between GIMAP7 expression and immune infiltration was determined using the TIMER2 database and the CIBERSORT method. ESTIMATE was used to analyse the correlation between GIMAP7 expression and ESTIMATE, immune and stromal scores. In addition, the correlation between GIMAP7 and immunoregulators was analysed. Furthermore, tumour mutational burden and microsatellite instability were evaluated using Spearman correlation assay. Results: GIMAP7 expression was significantly low and predicted better survival status in most tumour types. GIMAP7 was positively correlated with the abundance of CD8 + and CD4 + T cells in the tumour microenvironment. However, the high expression of GIMAP7 was negatively correlated with tumour mutations in uveal melanoma and colon adenocarcinoma. A correlation between GIMAP7 and microsatellite instability was found in rectal adenocarcinoma. Additionally, GIMAP7 presented a robust correlation between immune modulators and immunotherapeutic markers. Moreover, high GIMAP7 expression was significantly related to immune-relevant pathways. Conclusion:This study suggests the potential role of GIMAP7 as a prognostic and immunotherapeutic marker in pan-cancer, laying the groundwork for prospective functional and mechanistic experiments and their impact in the clinical setting.

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“…GIMAP 1 and GIMAP 6 have a fundamental role in maintaining the quantity of CD8+ T cells [17,21]. A positive correlation of all GIMAP family members with CD8+ T cell infiltration in lung cancer has been demonstrated [32]. GIMAP7 also has a positive correlation with CD8+ T cell infiltration in pancreatic adenocarcinoma [33].…”

Section: Discussionmentioning

confidence: 96%

Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images

Greco,

Panunzio,

Tafuri

et al. 2023

Genes

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GTPases of immunity-associated proteins (GIMAP) genes include seven functional genes and a pseudogene. Most of the GIMAPs have a role in the maintenance and development of lymphocytes. GIMAPs could inhibit the development of tumors by increasing the amount and antitumor activity of infiltrating immunocytes. Knowledge of key factors that affect the tumor immune microenvironment for predicting the efficacy of immunotherapy and establishing new targets in ccRCC is of great importance. A computed tomography (CT)-based radiogenomic approach was used to detect the imaging phenotypic features of GIMAP family gene expression in ccRCC. In this retrospective study we enrolled 193 ccRCC patients divided into two groups: ccRCC patients with GIMAP expression (n = 52) and ccRCC patients without GIMAP expression (n = 141). Several imaging features were evaluated on preoperative CT scan. A statistically significant correlation was found with absence of endophytic growth pattern (p = 0.049), tumor infiltration (p = 0.005), advanced age (p = 0.018), and high Fuhrman grade (p = 0.024). This study demonstrates CT imaging features of GIMAP expression in ccRCC. These results could allow the collection of data on GIMAP expression through a CT-approach and could be used for the development of a targeted therapy.

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Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma

Cited by 6 publications

References 26 publications

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR

GIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy

Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images

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