Systemic Anaphylaxis Following Local Lidocaine Administration During a Dental Procedure

Chiu, Chih Yung; Lin, Tzou Yien; Hsia, Shao Hsuan; Lai, Siang Hui; Wong, Kin Sun

doi:10.1097/01.pec.0000117928.65522.9e

Cited by 43 publications

(16 citation statements)

References 12 publications

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“…This antagonistic property of epinephrine limits the potential pressor effects of the drug as compared to other adrenergic VCs, which may cause major effects on systolic pressure, headache, palpitations or frequent fainting 7,[10][11] . The use of 3% mepivacaine without vasoconstrictor or with the vasoconstrictor felypressin (a vasopressin's synthetic analogue in association with prilocaine) can be an alternative to the use of adrenergic VCs, producing vasoconstriction in smooth muscle venules through the binding to receptors V1 and causing fewer cardiovascular side effects [5][6] . The choice of the anesthetic solution should take into account, in addition to the mechanisms of action and side effects associated with both LAs and VCs, the length of the procedure, need for hemostasis, control of postoperative pain and patients' characteristics, especially those with special needs [12][13] , on whom should be particularly observed the maximum recommended rates for these substances, presented in form of milligrams of the drug per unit of body weight.…”

Section: Dentists' Knowledge Regarding Signs and Symptoms Of The Systmentioning

confidence: 99%

Dentists' knowledge regarding signs and symptoms of the systemic toxicity of local anesthetic solutions

Pinheiro

Marques²,

Vieira³

et al. 2015

RGO, Rev. Gaúch. Odontol.

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ObjectiveTo evaluate the knowledge of dentists about signs and symptoms that may be indicative of systemic toxicity associated with the use of local anesthetic solutions. (Maranhão, Brazil) answered a questionnaire regarding the choice of solutions, selection criteria for local anesthetics and vasoconstrictors, and side effects associated with these substances. Results were analyzed by using descriptive statistics. Methods One hundred and twenty-four (124) dentists from private clinics in São Luís Results Although most respondents reported being likely to choose local anesthetics at less toxic concentrations (including 2% mepivacaine or lidocaine), they were also likely to have similar vasoconstrictor solutions (epinephrine) as the second choice. The main selection criteria of anesthetic solutions reported were the duration of procedures and patients' individual characteristics. In general, dentists demonstrated being aware of some side effects associated with vasoconstrictors; however, they showed a lack of knowledge regarding signs and symptoms related to an overdose of local anesthetics. Conclusion The group of dentists involved in this study showed limited knowledge about the toxicity of local anesthetics, as well as some inconsistent background over the choice of vasoconstrictors. Thus, strategies are required towards improving the knowledge of professionals from private dental clinics regarding local anesthetics and/or vasoconstrictors.Indexing terms: Local anesthetics. Vasoconstrictor agents. Toxicity. RESUMO ObjetivoAvaliar as soluções anestésicas utilizadas por um grupo de cirurgiões-dentistas e o nível de conhecimento desses profissionais sobre riscos associados a essas substâncias. MétodosCento e vinte e quatro (124) cirurgiões-dentistas da rede privada do município de São Luís (Maranhão, Brasil) responderam um questionário contendo perguntas relativas às soluções de escolha, aos critérios de escolha de anestésicos locais e vasoconstritores e à avaliação do conhecimento sobre os efeitos colaterais associados às substâncias.

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Section: Dentists' Knowledge Regarding Signs and Symptoms Of The Systmentioning

confidence: 99%

Dentists' knowledge regarding signs and symptoms of the systemic toxicity of local anesthetic solutions

Pinheiro

Marques²,

Vieira³

et al. 2015

RGO, Rev. Gaúch. Odontol.

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“…Its key improvements on procaine were that it had a faster speed of onset, a longer duration of action and allergic reactions were less likely. 15,16 Plain lignocaine has a vasodilating effect. It has a vasconstrictor added to its clinical preparations.…”

Section: Lignocainementioning

confidence: 99%

A concise review of the basic biology and pharmacology of local analgesia

Subramaniam

Tennant

2005

Australian Dental Journal

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Local analgesics are the most commonly used group drugs in dental practice. However, due to their frequent use and high margin of safety, often dental practitioners neglect to properly understand the biology and pharmacology of these drugs. This article reviews the basic concepts of pain, pain pathways, the mode of action of local analgesics and factors which affect their usage. Specific details and properties of some currently available solutions are also outlined. A greater understanding of the biology and pharmacology of local anaesthetics will ultimately lead to safer and more effective use in everyday clinical practice.

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“…Prevention of anaphylaxis depends primarily on the optimal management of patient-related risk factors, strict avoidance of confirmed relevant allergen or other triggers. Any drug administered can potentially produce life-threatening immune mediated hypersensitivity reactions [6]. Anaphylaxis is the most urgent of clinical allergic reactions.…”

Section: Introductionmentioning

confidence: 99%

The awareness of anaphylaxis reaction to local anesthesia in Dentistry

Eskandari¹,

Nekourad²,

Bastan³

2014

J Allergy Asthma

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Background: Anaphylaxis is one of the rare clinical events specifically related to anesthesia leading to morbidity and mortality. In this manner, the aim of our study was to determine knowledge of Iranian dentists about symptom, sign and management of anaphylaxis to local anesthesia. Methods: The study was designed with a questionnaire (16 questions) related to anaphylaxis to local anesthesia in Iran. The dentists working in their private office and clinic of medical dentist randomly selected and asked to complete questionnaire. Results: 72% of dentists accepted to take part in the study. Although all attendants knew one or more symptoms and signs of anaphylaxis but none of them marked all options related to anaphylaxis. In relation to, about 72.9% of dentists knew epinephrine as the first choice in the treatment of anaphylaxis shock, but only 20% of them had kept emergency equipments and facilities such as drugs in their offices to treat shock. This study showed that less than 10% of the dentists were aware of the recommended dose of epinephrine to use in adults or children. Conclusion: Our study concludes that some of dentists are not aware of this emergency vital clinical condition. Therefore, dentists should be developed their knowledge on the subject of the causes and treatment of anaphylaxis shock alternatively with attendance in related courses which holding by academic centers.

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Systemic Anaphylaxis Following Local Lidocaine Administration During a Dental Procedure

Cited by 43 publications

References 12 publications

Dentists' knowledge regarding signs and symptoms of the systemic toxicity of local anesthetic solutions

Dentists' knowledge regarding signs and symptoms of the systemic toxicity of local anesthetic solutions

A concise review of the basic biology and pharmacology of local analgesia

The awareness of anaphylaxis reaction to local anesthesia in Dentistry

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